Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Patella V et al. | Protein Fv produced during vital hepatitis is a novel activator of human basophils and mast cells. | 1993 | J. Immunol. | pmid:7693815 |
Kurosawa M et al. | Inhibition of bronchial hyperresponsiveness to histamine induced by intravenous administration of leukotriene C4 by novel thromboxane A2 receptor antagonists ONO-NT-126 and ONO-8809 in guinea-pigs. | 1993 | Clin. Exp. Allergy | pmid:10780891 |
González J et al. | Role of leukotrienes B4 and C4 in liver allograft rejection. | 1992 | Transpl. Int. | pmid:14621902 |
Agarwal R et al. | Glutathione S-transferase-dependent conjugation of leukotriene A4-methyl ester to leukotriene C4-methyl ester in mammalian skin. | 1992 | Biochem. Pharmacol. | pmid:1449522 |
Snyder DW et al. | Endogenously formed leukotriene C4 activates LTC4 receptors in guinea pig tracheal strips. | 1991 | Eur. J. Pharmacol. | pmid:1651863 |
De Servi S et al. | Transcardiac release of leukotriene C4 by neutrophils in patients with coronary artery disease. | 1991 | J. Am. Coll. Cardiol. | pmid:2007712 |
Baker SR et al. | The pharmacology of N-methyl LTC4; a metabolically stable LTC4-mimetic. | 1990 | Prostaglandins | pmid:2255765 |
Takase B | [Responses of plasma eicosanoids and hemodynamics to myocardial ischemia and the salutary effect of calcium entry blocker]. | 1990 | Nippon Ika Daigaku Zasshi | pmid:2329180 |
Kloprogge E et al. | Cellular communication in leukotriene C4 production between eosinophils and neutrophils. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2509375 |
Schauer U et al. | Enhanced leukotriene C4 production by peripheral eosinophilic granulocytes from children with asthma. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2512259 |