Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Shindo K et al. | Priming effect of platelet activating factor on leukotriene C4 from stimulated eosinophils of asthmatic patients. | 1996 | Thorax | pmid:8711647 |
Weide I et al. | Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. | 1993 | Thromb. Res. | pmid:8122190 |
Strenzke N et al. | Mercuric chloride enhances immunoglobulin E-dependent mediator release from human basophils. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11485386 |
Liu W et al. | Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22982073 |
Bridges CC et al. | MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21134393 |
Lee SJ et al. | 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK. | 2010 | Toxicol. Appl. Pharmacol. | pmid:19837106 |
Awasthi S et al. | ATP-Dependent colchicine transport by human erythrocyte glutathione conjugate transporter. | 1999 | Toxicol. Appl. Pharmacol. | pmid:10079207 |
Aleo MD et al. | An underlying role for hepatobiliary dysfunction in cyclosporine A nephrotoxicity. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18407308 |
Black AT et al. | Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20840853 |
Lin CH and Lai YL | Mast cell mediators in citric acid-induced airway constriction of guinea pigs. | 2005 | Toxicol. Appl. Pharmacol. | pmid:16039945 |