LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Hypotension D007022 41 associated lipids
Gastritis D005756 27 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Osteosarcoma D012516 50 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Asthma D001249 52 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Ulcer D014456 16 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Peritonitis D010538 38 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Leukemia D007938 74 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Myocardial Ischemia D017202 11 associated lipids
Glomerulonephritis D005921 35 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Nasal Polyps D009298 26 associated lipids
Ear Diseases D004427 7 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Anaphylaxis D000707 35 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Eosinophilia D004802 4 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Status Asthmaticus D013224 4 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Acute-Phase Reaction D000210 12 associated lipids
Uveitis D014605 14 associated lipids
Periapical Periodontitis D010485 6 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Angina Pectoris D000787 27 associated lipids
Hyperbilirubinemia, Hereditary D006933 3 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Drug Eruptions D003875 30 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Mesenteric Vascular Occlusion D008641 4 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Cestode Infections D002590 3 associated lipids
Neointima D058426 3 associated lipids
Asbestosis D001195 8 associated lipids
Phlebitis D010689 1 associated lipids
Picornaviridae Infections D010850 4 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
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Anwar AR et al. Adhesion to fibronectin primes eosinophils via alpha 4 beta 1 (VLA-4). 1994 Immunology pmid:7927493
Fujii R et al. Adenosine triphosphate-dependent transport of leukotriene C4 by membrane vesicles prepared from cisplatin-resistant human epidermoid carcinoma tumor cells. 1994 J. Natl. Cancer Inst. pmid:7966417
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Raible DG Erythrocytes increase leukotriene C4 release from human eosinophils: characterization and examination of possible mechanisms. 1994 J. Leukoc. Biol. pmid:8027672
Mitsuhashi T et al. Increased production of eicosanoids, TXA2, PGI2 and LTC4 in experimental spinal cord injuries. 1994 Paraplegia pmid:7970857
Volland H et al. Enzyme immunometric assay for leukotriene C4. 1994 J. Immunol. Methods pmid:7930643
Chen CR et al. Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids. 1994 Am. J. Respir. Crit. Care Med. pmid:8111595
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Petric R and Ford-Hutchinson AW Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. 1994 Kidney Int. pmid:7853790
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Aktan AO et al. Does PGE2 act as a mediator for endothelin release? 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7511821
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Bürgi B et al. The degradation product of the C5a anaphylatoxin C5adesarg retains basophil-activating properties. 1994 Eur. J. Immunol. pmid:7517876
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Miadonna A et al. Modulation of allergen-induced nasal symptoms and mediator release by treatment with N-acetyl-aspartyl-glutamate (ZY15106). 1994 Eur. J. Clin. Pharmacol. pmid:7518775
Yamamura H et al. Endothelin-1 induces release of histamine and leukotriene C4 from mouse bone marrow-derived mast cells. 1994 Eur. J. Pharmacol. pmid:7522171
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Matsumoto T et al. Effects of diet on experimentally induced intestinal ulcers in rats: morphology and tissue leukotrienes. 1994 Gut pmid:7926906
Shimizu T et al. Inhibitory effects of theophylline, terbutaline, and hydrocortisone on leukotriene B4 and C4 generation by human leukocytes in vitro. 1994 Pediatr. Pulmonol. pmid:7800427
Scadding GK et al. Effect of short-term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge. 1994 Br J Clin Pharmacol pmid:7893587
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Casellas F et al. Abnormal leukotriene C4 released by unaffected jejunal mucosa in patients with inactive Crohn's disease. 1994 Gut pmid:8174991
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Kapuściński A Leukotriene C4 in the rat brain after resuscitation from clinical death. 1994 Folia Neuropathol pmid:7922113
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