Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lecca D et al. | The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. | 2008 | PLoS ONE | pmid:18974869 |
Marchan R et al. | Multidrug resistance-associated protein 1 as a major mediator of basal and apoptotic glutathione release. | 2008 | Biochim. Biophys. Acta | pmid:18621020 |
Reichel V et al. | Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus. | 2008 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:18650317 |
Rothnie A et al. | Mechanistic differences between GSH transport by multidrug resistance protein 1 (MRP1/ABCC1) and GSH modulation of MRP1-mediated transport. | 2008 | Mol. Pharmacol. | pmid:18768387 |
Grant CE et al. | Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). | 2008 | Drug Metab. Dispos. | pmid:18775981 |
Tan Y and Lim LH | trans-Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation. | 2008 | Br. J. Pharmacol. | pmid:18776917 |
Chang WC et al. | Local Ca2+ influx through Ca2+ release-activated Ca2+ (CRAC) channels stimulates production of an intracellular messenger and an intercellular pro-inflammatory signal. | 2008 | J. Biol. Chem. | pmid:18156181 |
Blokzijl H et al. | Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease. | 2008 | J. Biol. Chem. | pmid:18838379 |
Qin L et al. | Residues responsible for the asymmetric function of the nucleotide binding domains of multidrug resistance protein 1. | 2008 | Biochemistry | pmid:19063607 |
Niwa Y et al. | Opposite effects of PU.1 on mast cell stimulation. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18680724 |
Yang JH et al. | Anti-allergic activity of an ethanol extract from Salviae miltiorrhiza. | 2008 | Arch. Pharm. Res. | pmid:19099230 |
Slot AJ et al. | Modulation of human multidrug resistance protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) transport activities by endogenous and exogenous glutathione-conjugated catechol metabolites. | 2008 | Drug Metab. Dispos. | pmid:18079363 |
Devakumar A et al. | Structural analysis of leukotriene C4 isomers using collisional activation and 157 nm photodissociation. | 2008 | J. Am. Soc. Mass Spectrom. | pmid:18024058 |
Thompson C et al. | Signaling by the cysteinyl-leukotriene receptor 2. Involvement in chemokine gene transcription. | 2008 | J. Biol. Chem. | pmid:18048362 |
Mustafa FB et al. | Honeybee venom secretory phospholipase A2 induces leukotriene production but not histamine release from human basophils. | 2008 | Clin. Exp. Immunol. | pmid:18005261 |
Wang J et al. | Does leukotriene affect intracellular glutathione redox state in cultured human airway epithelial cells? | 2008 | Antioxid. Redox Signal. | pmid:18199004 |
Heredi-Szabo K et al. | Characterization of 5(6)-carboxy-2,'7'-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4. | 2008 | J Biomol Screen | pmid:18349419 |
Létourneau IJ et al. | Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter. | 2008 | Biochem. Pharmacol. | pmid:18336795 |
Cao F et al. | Mrp2-related efflux of scutellarin in the intestinal absorption in rats. | 2008 | Pharmazie | pmid:18271309 |
Ito Y et al. | Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. | 2008 | BMB Rep | pmid:18315950 |
Bäck M | Cysteinyl-leukotrienes in cerebrovascular disease: angels and demons? | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18421005 |
Laengle UW et al. | Effects of latanoprost, timolol and GLC756, a novel dopamine D(2) agonist and D(1) antagonist on LTC(4) release after rat mast cell activation. | 2007 Sep-Oct | Clin. Experiment. Ophthalmol. | pmid:17894685 |
Zaitsu M et al. | Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx. | 2007 | Mol. Immunol. | pmid:17084457 |
Serio KJ et al. | TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16980379 |
Kowalski ML | Aspirin-sensitive rhinosinusitis and asthma. | 2007 | Clin Allergy Immunol | pmid:17153012 |
Bakos E and Homolya L | Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1). | 2007 | Pflugers Arch. | pmid:17187268 |
Nuutinen P et al. | Histamine, but not leukotriene C4, is an essential mediator in cold urticaria wheals. | 2007 | Acta Derm. Venereol. | pmid:17225008 |
Yoshisue H et al. | Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts. | 2007 | J. Allergy Clin. Immunol. | pmid:17208594 |
Lee KS et al. | Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. | 2007 | J. Allergy Clin. Immunol. | pmid:17208595 |
Yang SL and Lou YJ | Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats. | 2007 | Biochem. Pharmacol. | pmid:17194456 |
Ebihara S et al. | A simple preparation method for mouse eosinophils and their responses to anti-allergic drugs. | 2007 | Inflamm. Res. | pmid:17406808 |
Kopp MV et al. | Omalizumab (Xolair) in children with seasonal allergic rhinitis: leukotriene release as a potential in vitro parameter to monitor therapeutic effects. | 2007 | Pediatr Allergy Immunol | pmid:17680911 |
Capra V et al. | Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. | 2007 | Med Res Rev | pmid:16894531 |
Zhang XC et al. | Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17483291 |
Chang WC et al. | All-or-none activation of CRAC channels by agonist elicits graded responses in populations of mast cells. | 2007 | J. Immunol. | pmid:17911611 |
Blanchet MR et al. | Modulation of eosinophil activation in vitro by a nicotinic receptor agonist. | 2007 | J. Leukoc. Biol. | pmid:17289799 |
Yang SL et al. | Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats. | 2007 | J. Surg. Res. | pmid:17397868 |
Yang JJ et al. | Multidrug resistance protein 1 (MRP1) in rabbit conjunctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection. | 2007 | Pharm. Res. | pmid:17404811 |
Mortaz E et al. | Stimulation of cysteinyl leukotriene production in mast cells by heat shock and acetylsalicylic acid. | 2007 | Eur. J. Pharmacol. | pmid:17306251 |
Zhang L et al. | Mechanistic study on the intestinal absorption and disposition of baicalein. | 2007 | Eur J Pharm Sci | pmid:17507208 |
Létourneau IJ et al. | Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function. | 2007 | Drug Metab. Dispos. | pmid:17494643 |
Yang SL et al. | Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. | 2007 | Pharmacology | pmid:17496435 |
Liebhart J et al. | Production of leukotriene C4 by peripheral blood leukocytes stimulated with anti-fcepsilonRI antibody, PMA, and fMLP does not correlate with irreversible airway obstruction in asthmatics. | 2007 | J Investig Allergol Clin Immunol | pmid:17323856 |
Perrotton T et al. | (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. | 2007 | J. Biol. Chem. | pmid:17646169 |
Farias SE et al. | Transcellular biosynthesis of cysteinyl leukotrienes in rat neuronal and glial cells. | 2007 | J. Neurochem. | pmid:17711426 |
Liu YG and Luo JB | [Effects of among compositions of Herba Ephedrae decoction on genic xpression of 5-lipoxygenase activating protein, IL-4 and leukotriene C4 in asthmatic mice]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17432150 |
Rao NL et al. | Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17371808 |
Jame AJ et al. | Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. | 2007 | Clin. Exp. Allergy | pmid:17517102 |
Kramer MF et al. | Factors contributing to nasal allergic late phase eosinophilia. | 2006 May-Jun | Am J Otolaryngol | pmid:16647984 |
Shilling AD et al. | Use of canalicular membrane vesicles (CMVs) from rats, dogs, monkeys and humans to assess drug transport across the canalicular membrane. | 2006 May-Jun | J Pharmacol Toxicol Methods | pmid:16176877 |
Kim SJ et al. | Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2006 | Arch. Pharm. Res. | pmid:17121182 |
Ciana P et al. | The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. | 2006 | EMBO J. | pmid:16990797 |
Ninomiya M et al. | Functional analysis of mouse and monkey multidrug resistance-associated protein 2 (Mrp2). | 2006 | Drug Metab. Dispos. | pmid:16936067 |
Jordan TR et al. | [Clinical symptoms and mediators in the allergic early and late phase reaction]. | 2006 | Laryngorhinootologie | pmid:16498540 |
Hua Z et al. | Evaluation and interference of serum and skin lesion levels of leukotrienes in patients with eczema. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16757158 |
Chang WC et al. | Ca2+ influx through CRAC channels activates cytosolic phospholipase A2, leukotriene C4 secretion, and expression of c-fos through ERK-dependent and -independent pathways in mast cells. | 2006 | FASEB J. | pmid:17023391 |
Olynych TJ et al. | Fungal zymosan induces leukotriene production by human mast cells through a dectin-1-dependent mechanism. | 2006 | J. Allergy Clin. Immunol. | pmid:17030235 |
Medrala W et al. | [Efficacy and safety of specific immunotherapy of upper airways allergic diseases caused by allergy to mites]. | 2006 | Pol. Merkur. Lekarski | pmid:16875150 |
Zhang DW et al. | Mutational analysis of polar amino acid residues within predicted transmembrane helices 10 and 16 of multidrug resistance protein 1 (ABCC1): effect on substrate specificity. | 2006 | Drug Metab. Dispos. | pmid:16415113 |
Chavez J et al. | Interactions between leukotriene C4 and interleukin 13 signaling pathways in a mouse model of airway disease. | 2006 | Arch. Pathol. Lab. Med. | pmid:16594735 |
Wang XS and Lau HY | Beta-adrenoceptor-mediated inhibition of mediator release from human peripheral blood-derived mast cells. | 2006 | Clin. Exp. Pharmacol. Physiol. | pmid:16895550 |
Deng JM and Shi HZ | Interleukin-16 in asthma. | 2006 | Chin. Med. J. | pmid:16805986 |
Muñoz NM et al. | Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils. | 2006 | J. Immunol. | pmid:16785555 |
Tschopp CM et al. | Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. | 2006 | Blood | pmid:16794249 |
Engin A et al. | Regulation of fibrogenesis during the early phase of common bile duct obstruction. | 2006 | ANZ J Surg | pmid:16813633 |
Ra C | [IGE-FCepsilonRI-mast cell paradigm in allergy]. | 2006 | Arerugi | pmid:16718997 |
Thivierge M et al. | Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. | 2006 | J. Allergy Clin. Immunol. | pmid:16675346 |
Choi YH et al. | Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms. | 2006 | Arch. Pharm. Res. | pmid:16681034 |
Davoine F et al. | Interleukin-12 inhibits eosinophil degranulation and migration but does not promote eosinophil apoptosis. | 2006 | Int. Arch. Allergy Immunol. | pmid:16735797 |
Perng DW et al. | Leukotriene C4 induces TGF-beta1 production in airway epithelium via p38 kinase pathway. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16179583 |
Abad MJ et al. | Anti-inflammatory activity of four Bolivian Baccharis species (Compositae). | 2006 | J Ethnopharmacol | pmid:16202549 |
Uzonyi B et al. | Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16606835 |
Son MJ et al. | Naturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2006 | Arch. Pharm. Res. | pmid:16681032 |
Abe M et al. | A novel method for preserving human lungs using a super-cooling system. | 2006 | Ann. Thorac. Surg. | pmid:16928543 |
Hoopes C | Invited commentary. | 2006 | Ann. Thorac. Surg. | pmid:16928544 |
Zaitsu M et al. | Interleukin-18 primes human basophilic KU812 cells for higher leukotriene synthesis. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16280246 |
Dahlén SE | Treatment of asthma with antileukotrienes: first line or last resort therapy? | 2006 | Eur. J. Pharmacol. | pmid:16510137 |
Wijewickrama GT et al. | Systematic evaluation of transcellular activities of secretory phospholipases A2. High activity of group V phospholipases A2 to induce eicosanoid biosynthesis in neighboring inflammatory cells. | 2006 | J. Biol. Chem. | pmid:16476735 |
Gulliksson M et al. | Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells. | 2006 | Allergy | pmid:17073880 |
Li GQ et al. | Effects of cyclooxygenase-1 and -2 gene disruption on Helicobacter pylori-induced gastric inflammation. | 2006 | J. Infect. Dis. | pmid:16518767 |
Seres I et al. | The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome. | 2006 | J. Membr. Biol. | pmid:17546512 |
Cao D et al. | Chronic administration of ethyl docosahexaenoate reduces gerbil brain eicosanoid productions following ischemia and reperfusion. | 2006 | J. Nutr. Biochem. | pmid:16098734 |
Liu S et al. | Activation of connective tissue-type and mucosal-type mast cells in compound 48/80-induced airway response. | 2006 | Eur. J. Pharmacol. | pmid:16360144 |
Kalayci O et al. | ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. | 2006 | Allergy | pmid:16364163 |
Feng C et al. | Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses. | 2006 | Blood | pmid:16357326 |
Conseil G et al. | Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1). | 2006 | J. Biol. Chem. | pmid:16230346 |
Niide O et al. | Fungal metabolite gliotoxin blocks mast cell activation by a calcium- and superoxide-dependent mechanism: implications for immunosuppressive activities. | 2006 | Clin. Immunol. | pmid:16213796 |
Raghavenra H et al. | Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16216483 |
Kulka M and Metcalfe DD | TLR3 activation inhibits human mast cell attachment to fibronectin and vitronectin. | 2006 | Mol. Immunol. | pmid:16280166 |
Mesquita-Santos FP et al. | Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin. | 2006 | J. Immunol. | pmid:16424158 |
Chen X et al. | Five-lipoxygenase pathway of arachidonic acid metabolism in carcino-genesis and cancer chemoprevention. | 2006 | Curr Cancer Drug Targets | pmid:17100567 |
Ren XQ et al. | A functional role of intracellular loops of human multidrug resistance protein 1. | 2006 | J. Biochem. | pmid:16861249 |
Jordan TR et al. | An approach of immunoneurological aspects in nasal allergic late phase. | 2005 Sep-Oct | Allergy Asthma Proc | pmid:16450573 |
Payen L et al. | Functional interactions between nucleotide binding domains and leukotriene C4 binding sites of multidrug resistance protein 1 (ABCC1). | 2005 | Mol. Pharmacol. | pmid:15755910 |
Reims A et al. | Cysteinyl leukotrienes are secretagogues in atrophic coeliac and in normal duodenal mucosa of children. | 2005 | Scand. J. Gastroenterol. | pmid:15764146 |
John AE et al. | Temporal production of CCL28 corresponds to eosinophil accumulation and airway hyperreactivity in allergic airway inflammation. | 2005 | Am. J. Pathol. | pmid:15681819 |
Cruse G et al. | Activation of human lung mast cells by monomeric immunoglobulin E. | 2005 | Eur. Respir. J. | pmid:15863643 |
Ito K et al. | Mrp2/Abcc2 transport activity is stimulated by protein kinase Calpha in a baculo virus co-expression system. | 2005 | Life Sci. | pmid:15904671 |
Rossi MI et al. | Long-term exacerbation by interleukin 13 of IgE-mediated eosinophilia in rats. | 2005 | Int. Immunopharmacol. | pmid:15953562 |
Oskeritzian CA et al. | Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell. | 2005 | J. Allergy Clin. Immunol. | pmid:15940129 |