Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Eaton A et al. | Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression. | 2012 | J. Mol. Med. | pmid:22527886 |
Dannull J et al. | Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function. | 2012 | Blood | pmid:22323449 |
Fugazzola M et al. | Non-genomic action of beclomethasone dipropionate on bronchoconstriction caused by leukotriene C4 in precision cut lung slices in the horse. | 2012 | BMC Vet. Res. | pmid:22963524 |
Hong F and Yang S | Ischemic preconditioning decreased leukotriene C4 formation by depressing leukotriene C4 synthase expression and activity during hepatic I/R injury in rats. | 2012 | J. Surg. Res. | pmid:22921920 |
Liu W et al. | Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22982073 |
Lu Y et al. | Saucerneol D inhibits eicosanoid generation and degranulation through suppression of Syk kinase in mast cells. | 2012 | Food Chem. Toxicol. | pmid:22982805 |
Rinaldo-Matthis A et al. | Pre-steady-state kinetic characterization of thiolate anion formation in human leukotriene Câ‚„ synthase. | 2012 | Biochemistry | pmid:22217203 |
Ng SW et al. | Cysteinyl leukotriene type I receptor desensitization sustains Ca2+-dependent gene expression. | 2012 | Nature | pmid:22230957 |
Iram SH and Cole SP | Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1). | 2012 | J. Biol. Chem. | pmid:22232552 |
Chae HS and Chin YW | Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells. | 2012 | Immunopharmacol Immunotoxicol | pmid:21854102 |
Han YS et al. | Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells. | 2012 | Inflammation | pmid:22729280 |
Sodani K et al. | Multidrug resistance associated proteins in multidrug resistance. | 2012 | Chin J Cancer | pmid:22098952 |
Jiang W et al. | UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP. | 2012 | Drug Metab. Dispos. | pmid:22071170 |
Bridges CC et al. | MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21134393 |
Becher UM et al. | Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury. | 2011 | J. Mol. Cell. Cardiol. | pmid:21112334 |
Zhu Y and Bertics PJ | Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils. | 2011 | J. Immunol. | pmid:21106848 |
Megaraj V et al. | Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2). | 2011 | Pharmacogenet. Genomics | pmid:21691255 |
Furukawa M et al. | Terpenoids and phenethyl glucosides from Hyssopus cuspidatus (Labiatae). | 2011 | Phytochemistry | pmid:21893325 |
Alvarez C et al. | Leukotriene C(4) prevents the complete maturation of murine dendritic cells and modifies interleukin-12/interleukin-23 balance. | 2011 | Immunology | pmid:21896013 |
Jin M et al. | Luteolin-7-O-glucoside suppresses leukotriene C(4) production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cγ1 in activated mouse bone marrow-derived mast cells. | 2011 | Biol. Pharm. Bull. | pmid:21720009 |