LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Hypotension D007022 41 associated lipids
Gastritis D005756 27 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Osteosarcoma D012516 50 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Asthma D001249 52 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Ulcer D014456 16 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Peritonitis D010538 38 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Leukemia D007938 74 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Myocardial Ischemia D017202 11 associated lipids
Glomerulonephritis D005921 35 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Nasal Polyps D009298 26 associated lipids
Ear Diseases D004427 7 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Anaphylaxis D000707 35 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Eosinophilia D004802 4 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Status Asthmaticus D013224 4 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Acute-Phase Reaction D000210 12 associated lipids
Uveitis D014605 14 associated lipids
Periapical Periodontitis D010485 6 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Angina Pectoris D000787 27 associated lipids
Hyperbilirubinemia, Hereditary D006933 3 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Drug Eruptions D003875 30 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Mesenteric Vascular Occlusion D008641 4 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Cestode Infections D002590 3 associated lipids
Neointima D058426 3 associated lipids
Asbestosis D001195 8 associated lipids
Phlebitis D010689 1 associated lipids
Picornaviridae Infections D010850 4 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Chen ZS et al. Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). 2003 Mol. Pharmacol. pmid:12527806
Chen ZS et al. Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. 1999 Mol. Pharmacol. pmid:10570049
Ravasi S et al. A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma. 2000 Mol. Pharmacol. pmid:10825389
van Aubel RA et al. Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells. 1998 Mol. Pharmacol. pmid:9614209
Van Aubel RA et al. Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells. 1999 Mol. Pharmacol. pmid:10496953
Bandler PE et al. Identification of regions required for apical membrane localization of human multidrug resistance protein 2. 2008 Mol. Pharmacol. pmid:18381564
Payen L et al. Functional interactions between nucleotide binding domains and leukotriene C4 binding sites of multidrug resistance protein 1 (ABCC1). 2005 Mol. Pharmacol. pmid:15755910
Wu P et al. Analysis of human multidrug resistance protein 1 (ABCC1) by matrix-assisted laser desorption ionization/time of flight mass spectrometry: toward identification of leukotriene C4 binding sites. 2005 Mol. Pharmacol. pmid:16105987
Zaitsu M et al. Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx. 2007 Mol. Immunol. pmid:17084457
Kulka M and Metcalfe DD TLR3 activation inhibits human mast cell attachment to fibronectin and vitronectin. 2006 Mol. Immunol. pmid:16280166
Szabó Z et al. ABCC6 does not transport adenosine - relevance to pathomechanism of pseudoxanthoma elasticum. 2011 Mol. Genet. Metab. pmid:21813308
Zhang X et al. Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels. 2013 Mol. Cell. Biol. pmid:23878392
Lu Y et al. Citreorosein inhibits degranulation and leukotriene Câ‚„ generation through suppression of Syk pathway in mast cells. 2012 Mol. Cell. Biochem. pmid:22395859
Mueller CF et al. Angiotensin II triggers release of leukotriene C4 in vascular smooth muscle cells via the multidrug resistance-related protein 1. 2010 Mol. Cell. Biochem. pmid:19685171
Kar P et al. Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals. 2016 Mol. Cell pmid:27863227
Godinot N et al. Cloning and functional characterization of the multidrug resistance-associated protein (MRP1/ABCC1) from the cynomolgus monkey. 2003 Mol. Cancer Ther. pmid:12657726
Ma L et al. Identification and characterization of the canine multidrug resistance-associated protein. 2002 Mol. Cancer Ther. pmid:12516967
Okubo M et al. Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors. 2010 Mol Pain pmid:20846451
Eppihimer MJ and Schaub RG Soluble P-selectin antagonist mediates rolling velocity and adhesion of leukocytes in acutely inflamed venules. 2001 Microcirculation pmid:11296849
Schäfer S and Walland A Staurosporine inhibits the effects of leukotrienes C4 and D4 in isolated guinea pig heart and trachea. 1995 Methods Find Exp Clin Pharmacol pmid:8577209
Malaviya R and Abraham SN Interaction of bacteria with mast cells. 1995 Meth. Enzymol. pmid:7476393
Keppler D et al. Transport function and substrate specificity of multidrug resistance protein. 1998 Meth. Enzymol. pmid:9711586
Nobukata H et al. Long-term administration of highly purified eicosapentaenoic acid ethyl ester improves the dysfunction of vascular endothelial and smooth muscle cells in male WBN/Kob rats. 2000 Metab. Clin. Exp. pmid:11145121
Seres I et al. Angiotensin II-induced oxidative burst is fluvastatin sensitive in neutrophils of patients with hypercholesterolemia. 2005 Metab. Clin. Exp. pmid:16125525
Tang F et al. Inhibitory effect of methyleugenol on IgE-mediated allergic inflammation in RBL-2H3 cells. 2015 Mediators Inflamm. pmid:25960618
Desplat V et al. Incorporation and effect of arachidonic acid on the growth of human myeloma cell lines. 1999 Mediators Inflamm. pmid:10704149
Haberl C et al. Release of prostaglandin D2 by murine mast cells: importance of metabolite formation for antiproliferative activity. 1998 Mediators Inflamm. pmid:9836493
Ribeiro LR et al. Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis. 2015 Mediators Inflamm. pmid:26635449
Capra V et al. Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. 2007 Med Res Rev pmid:16894531
Mullol J et al. [Eosinophil activation by epithelial cells of the respiratory mucosa. Comparative study of normal mucosa and inflammatory mucosa]. 1997 Med Clin (Barc) pmid:9303983
Aiso M et al. Biliary excretion of bile acids and organic anions in zone 1- and zone 3-injured rats. 2000 Liver pmid:10726959
Yoo JM et al. Inhibitory effect of N-Acyl dopamines on IgE-mediated allergic response in RBL-2H3 cells. 2013 Lipids pmid:23377981
Bermejo Benito P et al. In vivo and in vitro antiinflammatory activity of saikosaponins. 1998 Life Sci. pmid:9763210
Huang SC Leukotriene-induced contraction is mediated by cysteinyl leukotriene receptor CysLT1 in guinea pig fundus but by CysLT1 and CysLT2 in antrum. 2011 Life Sci. pmid:21396378
Zhu X et al. Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin. 2003 Life Sci. pmid:14519449
de las Heras B et al. Effects of six diterpenes on macrophage eicosanoid biosynthesis. 2001 Life Sci. pmid:12005260
Yakubu MA and Leffler CW Enhanced pial arteriolar sensitivity to bioactive agents following exposure to endothelin-1. 2000 Life Sci. pmid:10665982
Hisamatsu K and Nakajima M Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro. 2000 Life Sci. pmid:11105993
Díaz AM et al. Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity. 2004 Life Sci. pmid:15010262
Wang M et al. The responses of pulmonary and systemic circulation and airway to anaphylactic mediators in anesthetized BALB/c mice. 2016 Life Sci. pmid:26808090
Lopes LR et al. Reduced inflammatory response in rats fed fat-rich diets: role of leukotrienes. 2000 Life Sci. pmid:10896024
Ito K et al. Mrp2/Abcc2 transport activity is stimulated by protein kinase Calpha in a baculo virus co-expression system. 2005 Life Sci. pmid:15904671
Sato H et al. Biological characteristics of chronic eosinophilic leukemia cells with a t(2;5)(p23;q35) translocation. 1995 Leuk. Lymphoma pmid:8590853
Ramanujam D et al. Dramatic resolution of respiratory symptoms with imatinib mesylate in patients with chronic myeloid leukemia presenting with lower airway symptoms resembling asthma. 2009 Leuk. Lymphoma pmid:19757309
Arango P and Kountakis SE Presence of cysteinyl leukotrienes in asthmatic patients with chronic sinusitis. 2002 Laryngoscope pmid:12169896
Jordan TR et al. [Clinical symptoms and mediators in the allergic early and late phase reaction]. 2006 Laryngorhinootologie pmid:16498540
Mayatepek E and Flock B Leukotriene C4-synthesis deficiency: a new inborn error of metabolism linked to a fatal developmental syndrome. 1998 Lancet pmid:9820300
Petric R and Ford-Hutchinson AW Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. 1994 Kidney Int. pmid:7853790
Fujita M et al. Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs. 1997 Jpn. J. Pharmacol. pmid:9469641
Ishii K et al. A useful method for differential evaluation of anti-inflammatory effects due to cyclooxygenase and 5-lipoxygenase inhibitions in mice. 1994 Jpn. J. Pharmacol. pmid:7990266