LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kohrogi H et al. | Release of tachykinins and its metabolism in the airway. | 1993 | Regul. Pept. | pmid:8210488 |
| Westcott JY et al. | Inactivation of peptidoleukotrienes in the isolated perfused rat lung. | 1993 | Arch. Biochem. Biophys. | pmid:7692821 |
| González J et al. | Role of leukotrienes B4 and C4 in liver allograft rejection. | 1992 | Transpl. Int. | pmid:14621902 |
| Agarwal R et al. | Glutathione S-transferase-dependent conjugation of leukotriene A4-methyl ester to leukotriene C4-methyl ester in mammalian skin. | 1992 | Biochem. Pharmacol. | pmid:1449522 |
| Snyder DW et al. | Endogenously formed leukotriene C4 activates LTC4 receptors in guinea pig tracheal strips. | 1991 | Eur. J. Pharmacol. | pmid:1651863 |
| De Servi S et al. | Transcardiac release of leukotriene C4 by neutrophils in patients with coronary artery disease. | 1991 | J. Am. Coll. Cardiol. | pmid:2007712 |
| Baker SR et al. | The pharmacology of N-methyl LTC4; a metabolically stable LTC4-mimetic. | 1990 | Prostaglandins | pmid:2255765 |
| Takase B | [Responses of plasma eicosanoids and hemodynamics to myocardial ischemia and the salutary effect of calcium entry blocker]. | 1990 | Nippon Ika Daigaku Zasshi | pmid:2329180 |
| Sternfeld M et al. | The role of acupuncture in asthma: changes in airways dynamics and LTC4 induced LAI. | 1989 | Am. J. Chin. Med. | pmid:2633615 |
| Kloprogge E et al. | Cellular communication in leukotriene C4 production between eosinophils and neutrophils. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2509375 |
| Schauer U et al. | Enhanced leukotriene C4 production by peripheral eosinophilic granulocytes from children with asthma. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2512259 |
| Paoletti P et al. | CSF leukotriene C4 following subarachnoid hemorrhage. | 1988 | J. Neurosurg. | pmid:3418380 |
| Romero R et al. | Increased amniotic fluid leukotriene C4 concentration in term human parturition. | 1988 | Am. J. Obstet. Gynecol. | pmid:3421265 |
| Angi MR et al. | [Quantitative evaluation of conjunctival irritation by simultaneous determination of histamine, serotonin and leukotriene C4 in tears]. | 1987 Oct-Dec | Ophtalmologie | pmid:3153930 |
| Maury G et al. | Racemic LTA4 methyl ester bioconversion into LTC4 methyl ester by various glutathione S-transferases. | 1987 | Biochem. Int. | pmid:3125835 |
| Talbot SF et al. | Accumulation of leukotriene C4 and histamine in human allergic skin reactions. | 1985 | J. Clin. Invest. | pmid:2411760 |
| Pönicke K and Förster W | Influence of leukotriene C4 on aggregation and on malondialdehyde formation of human blood platelets. | 1984 | Biomed. Biochim. Acta | pmid:6440558 |
| Mannervik B et al. | Transformation of leukotriene A4 methyl ester to leukotriene C4 monomethyl ester by cytosolic rat glutathione transferases. | 1984 | FEBS Lett. | pmid:6548194 |
| Folco G et al. | Leukotriene C4 stimulates TXA2 formation in isolated sensitized guinea pig lungs. | 1981 | Biochem. Pharmacol. | pmid:21043253 |
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