LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Hypotension D007022 41 associated lipids
Gastritis D005756 27 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Osteosarcoma D012516 50 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Asthma D001249 52 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Ulcer D014456 16 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Peritonitis D010538 38 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Leukemia D007938 74 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Myocardial Ischemia D017202 11 associated lipids
Glomerulonephritis D005921 35 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Nasal Polyps D009298 26 associated lipids
Ear Diseases D004427 7 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Anaphylaxis D000707 35 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Eosinophilia D004802 4 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Status Asthmaticus D013224 4 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Acute-Phase Reaction D000210 12 associated lipids
Uveitis D014605 14 associated lipids
Periapical Periodontitis D010485 6 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Angina Pectoris D000787 27 associated lipids
Hyperbilirubinemia, Hereditary D006933 3 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Drug Eruptions D003875 30 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Mesenteric Vascular Occlusion D008641 4 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Cestode Infections D002590 3 associated lipids
Neointima D058426 3 associated lipids
Asbestosis D001195 8 associated lipids
Phlebitis D010689 1 associated lipids
Picornaviridae Infections D010850 4 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Findlay VJ et al. Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug. 2004 Mol. Pharmacol. pmid:15102935
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Gentile DA et al. Elevations of local leukotriene C4 levels during viral upper respiratory tract infections. 2003 Ann. Allergy Asthma Immunol. pmid:14533659
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Llupià J et al. Comparative antiallergic effects of second-generation H1-antihistamines ebastine, cetirizine and loratadine in preclinical models. 2003 Arzneimittelforschung pmid:12642964
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Muñoz NM et al. Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. 2003 J. Biol. Chem. pmid:12796497
Dallaire MJ et al. Endothelial cells modulate eosinophil surface markers and mediator release. 2003 Eur. Respir. J. pmid:12797482
Cai Y et al. Bronchial mast cells are the dominating LTC4S-expressing cells in aspirin-tolerant asthma. 2003 Am. J. Respir. Cell Mol. Biol. pmid:12816731
Miller LA et al. Glutathione, S-substituted glutathiones, and leukotriene C4 as substrates for peptidylglycine alpha-amidating monooxygenase. 2003 Arch. Biochem. Biophys. pmid:12646261
Strait RT et al. IL-4 exacerbates anaphylaxis. 2003 J. Immunol. pmid:12646651
Fujisaki T et al. Bestatin selectively suppresses the growth of leukemic stem/progenitor cells with BCR/ABL mRNA transcript in patients with chronic myelogeneous leukemia. 2003 Int. Immunopharmacol. pmid:12781706
Arumugam TV et al. Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. 2003 Br. J. Pharmacol. pmid:12967936
Zhang DW et al. Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state. 2003 J. Biol. Chem. pmid:12954620
Kowalski ML et al. Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. 2003 J. Allergy Clin. Immunol. pmid:13679808
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Lee TK et al. N-glycosylation controls functional activity of Oatp1, an organic anion transporter. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12702494
Liu P et al. Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12531730
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Kwak WJ et al. Papyriflavonol A from Broussonetia papyrifera inhibits the passive cutaneous anaphylaxis reaction and has a secretory phospholipase A2-inhibitory activity. 2003 Biol. Pharm. Bull. pmid:12612436
Plath KE et al. Calcineurin antagonists differentially affect mediator secretion, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases from immunologically activated human basophils. 2003 Clin. Exp. Allergy pmid:12614449
Venkatachalam TK et al. Substituted heterocyclic thiourea compounds as a new class of anti-allergic agents inhibiting IgE/Fc epsilon RI receptor mediated mast cell leukotriene release. 2003 Bioorg. Med. Chem. pmid:12614897
Hattori T et al. Effects of H2O2 on membrane potential of smooth muscle cells in rabbit mesenteric resistance artery. 2003 Eur. J. Pharmacol. pmid:12620501
Söderström M et al. Expression of leukotriene C4 synthase mRNA by the choroid plexus in mouse brain suggests novel neurohormone functions of cysteinyl leukotrienes. 2003 Biochem. Biophys. Res. Commun. pmid:12878209
Zaitsu M et al. Dexamethasone accelerates catabolism of leukotriene C4 in bronchial epithelial cells. 2003 Eur. Respir. J. pmid:12882448
Meliton AY et al. Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils. 2003 J. Allergy Clin. Immunol. pmid:12897749
Chen X et al. [Preventive effects of montelukast on hypoxic pulmonary hypertension in rats]. 2003 Sichuan Da Xue Xue Bao Yi Xue Ban pmid:12910720
Lie WJ et al. Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. 2003 Clin. Exp. Allergy pmid:12911788
Ichiyama T et al. Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells. 2003 Clin. Exp. Allergy pmid:12801316
Mizutani N [Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms]. 2003 Yakugaku Zasshi pmid:12607939
Bouchelouche K et al. The cysteinyl-leukotriene D4 induces cytosolic Ca2+ elevation and contraction of the human detrusor muscle. 2003 J. Urol. pmid:12853847
Mechiche H et al. Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites. 2003 Clin. Exp. Allergy pmid:12859443
Nagase T et al. A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12505870