Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Skaltsa H et al. | Inhibition of prostaglandin E2 and leukotriene C4 in mouse peritoneal macrophages and thromboxane B2 production in human platelets by flavonoids from Stachys chrysantha and Stachys candida. | 2000 | Biol. Pharm. Bull. | pmid:10706410 |
Desplat V et al. | Incorporation and effect of arachidonic acid on the growth of human myeloma cell lines. | 1999 | Mediators Inflamm. | pmid:10704149 |
Yamashita M et al. | Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells. | 2000 | Br. J. Pharmacol. | pmid:10694244 |
Gutmann H et al. | P-glycoprotein- and mrp2-mediated octreotide transport in renal proximal tubule. | 2000 | Br. J. Pharmacol. | pmid:10694230 |
Mayatepek E et al. | Analysis of leukotrienes in cerebrospinal fluid of a reference population and patients with inborn errors of metabolism: further evidence for a pathognomonic profile in LTC(4)-synthesis deficiency. | 2000 | Clin. Chim. Acta | pmid:10686285 |
Amann R et al. | Eicosanoid release in the endotoxin-primed isolated perfused rat lung and its pharmacological modification. | 1999 | Inflamm. Res. | pmid:10669114 |
Herman CA and Luczy-Bachman G | Eicosanoids in the brain of warm- and cold-acclimated bullfrogs. | 1999 | Adv. Exp. Med. Biol. | pmid:10667397 |
Schweitzer P et al. | Cannabinoid modulation of neuronal activity in adult rat hippocampus. | 1999 | Adv. Exp. Med. Biol. | pmid:10667381 |
Lieberman MW et al. | Gamma-glutamyl leukotrienase cleavage of leukotriene C4. | 1999 | Adv. Exp. Med. Biol. | pmid:10667345 |
Sjölinder M et al. | Aberrant expression of active leukotriene C(4) synthase in CD16(+) neutrophils from patients with chronic myeloid leukemia. | 2000 | Blood | pmid:10666225 |
Yakubu MA and Leffler CW | Enhanced pial arteriolar sensitivity to bioactive agents following exposure to endothelin-1. | 2000 | Life Sci. | pmid:10665982 |
Ding GY et al. | Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles. | 1999 Jul-Aug | Anticancer Res. | pmid:10652618 |
Tsang S et al. | Simplified purification of human basophils. | 2000 | J. Immunol. Methods | pmid:10648851 |
Sundkvist E et al. | Leukotriene C(4) (LTC(4)) does not share a cellular efflux mechanism with cGMP: characterisation of cGMP transport by uptake to inside-out vesicles from human erythrocytes. | 2000 | Biochim. Biophys. Acta | pmid:10631301 |
Bandeira-Melo C et al. | Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. | 2000 | J. Immunol. | pmid:10623853 |
Norman BH et al. | Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10612603 |
Cracowski JL et al. | Functional comparison of the human isolated femoral artery, internal mammary artery, gastroepiploic artery, and saphenous vein. | 1999 | Can. J. Physiol. Pharmacol. | pmid:10588481 |
Chen ZS et al. | Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. | 1999 | Mol. Pharmacol. | pmid:10570049 |
Rao AM et al. | CDP-choline: neuroprotection in transient forebrain ischemia of gerbils. | 1999 | J. Neurosci. Res. | pmid:10561698 |
Mao Q et al. | ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells. | 1999 | Biochim. Biophys. Acta | pmid:10556489 |
Lankisch TO et al. | High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. | 1999 | Eur. J. Cell Biol. | pmid:10535305 |
Ko JK and Cho CH | Co-regulation of mucosal nitric oxide and prostaglandin in gastric adaptive cytoprotection. | 1999 | Inflamm. Res. | pmid:10522801 |
May A et al. | Means of increasing sensitivity of an in vitro diagnostic test for aspirin intolerance. | 1999 | Clin. Exp. Allergy | pmid:10520062 |
Muñoz NM et al. | Augmentation of eosinophil degranulation and LTC(4) secretion by integrin-mediated endothelial cell adhesion. | 1999 | Am. J. Physiol. | pmid:10516222 |
Schmidt D et al. | Passive sensitization of human airways increases responsiveness to leukotriene C4. | 1999 | Eur. Respir. J. | pmid:10515407 |
Van Aubel RA et al. | Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells. | 1999 | Mol. Pharmacol. | pmid:10496953 |
Rao AM et al. | Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils. | 1999 | Neurochem. Res. | pmid:10492517 |
Hagmann W et al. | Purification of the human apical conjugate export pump MRP2 reconstitution and functional characterization as substrate-stimulated ATPase. | 1999 | Eur. J. Biochem. | pmid:10491184 |
Nakasato H et al. | Prevention of severe premenstrual asthma attacks by leukotriene receptor antagonist. | 1999 | J. Allergy Clin. Immunol. | pmid:10482831 |
Sarau HM et al. | Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. | 1999 | Mol. Pharmacol. | pmid:10462554 |
Kawabe T et al. | Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). | 1999 | FEBS Lett. | pmid:10456333 |
Campbell EM et al. | Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. | 1999 | J. Immunol. | pmid:10438957 |
Falcón-Pérez JM et al. | Functional domain analysis of the yeast ABC transporter Ycf1p by site-directed mutagenesis. | 1999 | J. Biol. Chem. | pmid:10438540 |
Stride BD et al. | Localization of a substrate specificity domain in the multidrug resistance protein. | 1999 | J. Biol. Chem. | pmid:10428874 |
Kamisako T et al. | Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. | 1999 | Hepatology | pmid:10421658 |
Rappa G et al. | New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models. | 1999 | Biochem. Pharmacol. | pmid:10413292 |
Dantzig AH et al. | Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10411602 |
Irkeç MT et al. | Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. | 1999 | Ocul. Immunol. Inflamm. | pmid:10410873 |
Clish CB et al. | Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393980 |
Bischoff SC et al. | IL-4 enhances proliferation and mediator release in mature human mast cells. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393951 |
Cordoba-Rodriguez R et al. | Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393875 |
Lynch KR et al. | Characterization of the human cysteinyl leukotriene CysLT1 receptor. | 1999 | Nature | pmid:10391245 |
Vellenga E et al. | Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. | 1999 | Br. J. Pharmacol. | pmid:10385244 |
Miadonna A et al. | Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. | 1999 | Clin. Exp. Allergy | pmid:10383595 |
Gibbs BF and Grabbe J | Inhibitors of PI 3-kinase and MEK kinase differentially affect mediator secretion from immunologically activated human basophils. | 1999 | J. Leukoc. Biol. | pmid:10380914 |
Chen ZS et al. | An enhanced active efflux of CPT-11 and SN-38 in cisplatin-resistant human KB carcinoma cells. | 1999 | Cancer Lett. | pmid:10378768 |
Kita H et al. | Does IgE bind to and activate eosinophils from patients with allergy? | 1999 | J. Immunol. | pmid:10352312 |
Sano A et al. | Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10351938 |
Hipfner DR et al. | Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein. | 1999 | J. Biol. Chem. | pmid:10336431 |
Niinuma K et al. | Primary active transport of organic anions on bile canalicular membrane in humans. | 1999 | Am. J. Physiol. | pmid:10330006 |
Denizot Y et al. | Are lipid mediators implicated in the production of pro- and anti-inflammatory cytokines during cardiopulmonary bypass graft with extracorporeal circulation? | 1999 | Cytokine | pmid:10328869 |
Hamasaki Y et al. | Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells. | 1999 | Planta Med. | pmid:10232065 |
Nilsen A et al. | Short-term exposure of rodents to diesel exhausts: usefulness for studies of genotoxic and immunotoxic effects. | 1999 | Chem. Biol. Interact. | pmid:10227576 |
Takao A et al. | Inhibitory effects of azelastine hydrochloride in alcohol-induced asthma. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10227338 |
Mayatepek E et al. | A severely affected infant with absence of cysteinyl leukotrienes in cerebrospinal fluid: further evidence that leukotriene C4-synthesis deficiency is a new neurometabolic disorder. | 1999 | Neuropediatrics | pmid:10222453 |
Masereeuw R et al. | Active lucifer yellow secretion in renal proximal tubule: evidence for organic anion transport system crossover. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10215693 |
Malaviya R and Uckun FM | Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10208864 |
Held HD et al. | Characterization of airway and vascular responses in murine lungs. | 1999 | Br. J. Pharmacol. | pmid:10205008 |
Constable AL et al. | DMSO induction of the leukotriene LTC4 by Lewis rat Schwann cells. | 1999 | J. Neurol. Sci. | pmid:10202977 |
Miura K et al. | Extracellular signal-regulated kinases regulate leukotriene C4 generation, but not histamine release or IL-4 production from human basophils. | 1999 | J. Immunol. | pmid:10201947 |
Carvalho-Tavares J et al. | Assessment of the mechanism of juxtacrine activation and adhesion of leukocytes in liver microcirculation. | 1999 | Am. J. Physiol. | pmid:10198324 |
McWherter CA et al. | Circular permutation of the granulocyte colony-stimulating factor receptor agonist domain of myelopoietin. | 1999 | Biochemistry | pmid:10194378 |
Keskil ZA et al. | Changes of arterial arachidonic acid metabolites in hypertensive patients during haemodialysis. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10189068 |
Renes J et al. | ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. | 1999 | Br. J. Pharmacol. | pmid:10188979 |
Zaitsu M et al. | Effect of dexamethasone on leukotriene synthesis in DMSO-stimulated HL-60 cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10102384 |
O'Connor BJ et al. | Selective airway responsiveness in asthma. | 1999 | Trends Pharmacol. Sci. | pmid:10101956 |
Lay JC et al. | Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10100994 |
Awasthi S et al. | ATP-Dependent colchicine transport by human erythrocyte glutathione conjugate transporter. | 1999 | Toxicol. Appl. Pharmacol. | pmid:10079207 |
Sakamoto H et al. | Enhancement of glucuronosyl etoposide transport by glutathione in multidrug resistance-associated protein-overexpressing cells. | 1999 | Cancer Lett. | pmid:10077229 |
Collin N et al. | [Search for a threshold to distinguish between locoregional and systemic reactions using the histamine liberation value and the LTC4 level]. | 1999 | Allerg Immunol (Paris) | pmid:10070593 |
Sjölinder M et al. | Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. | 1999 | J. Lipid Res. | pmid:10064732 |
Nakamura T et al. | Direct interaction between a quinoline derivative, MS-209, and multidrug resistance protein (MRP) in human gastric cancer cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10049760 |
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