Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Romero R et al. | Increased amniotic fluid leukotriene C4 concentration in term human parturition. | 1988 | Am. J. Obstet. Gynecol. | pmid:3421265 |
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Huber W et al. | Leukotriene B4 and C4 production in isolated rat gastric mucosal cells. | 1993 | Am. J. Physiol. | pmid:8279553 |
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Brady HR et al. | Lipoxygenase product formation and cell adhesion during neutrophil-glomerular endothelial cell interaction. | 1995 | Am. J. Physiol. | pmid:7840235 |
Carvalho-Tavares J et al. | Assessment of the mechanism of juxtacrine activation and adhesion of leukocytes in liver microcirculation. | 1999 | Am. J. Physiol. | pmid:10198324 |
Fiorucci S et al. | Effect of NSAIDs on pepsinogen secretion and calcium mobilization in isolated chief cells. | 1995 | Am. J. Physiol. | pmid:7611418 |
Muñoz NM et al. | Augmentation of eosinophil degranulation and LTC(4) secretion by integrin-mediated endothelial cell adhesion. | 1999 | Am. J. Physiol. | pmid:10516222 |
Ohtsuki T et al. | Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain. | 1995 | Am. J. Physiol. | pmid:7900879 |
Sato E et al. | Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. | 1998 | Am. J. Physiol. | pmid:9609736 |
Abela A and Daniel EE | Neural and myogenic effects of leukotrienes C4, D4, and E4 on canine bronchial smooth muscle. | 1994 | Am. J. Physiol. | pmid:8179018 |
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Sano A et al. | Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA(2). | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11557588 |
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Kingham PJ et al. | Adhesion-dependent interactions between eosinophils and cholinergic nerves. | 2002 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12003778 |
Sawatzky DA et al. | Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation. | 2002 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12003784 |
Oliveira SH et al. | SCF-induced airway hyperreactivity is dependent on leukotriene production. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11350804 |
Muñoz NM et al. | Augmentation of LTC(4) synthesis in human eosinophils caused by CD3-stimulated Th2-like cells in vitro. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10835322 |
Nagase T et al. | A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12505870 |
Vargaftig BB and Singer M | Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12388339 |
Miller DS et al. | Xenobiotic efflux pumps in isolated fish brain capillaries. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11742838 |
Reichel V et al. | Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus. | 2008 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:18650317 |
Downey P et al. | Renal concentrating defect in mice lacking group IV cytosolic phospholipase A(2). | 2001 | Am. J. Physiol. Renal Physiol. | pmid:11249852 |
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Sanchez Mejia RO et al. | Matrix-associated transforming growth factor-beta1 primes mouse bone marrow-derived mast cells for increased high-affinity Fc receptor for immunoglobulin E-dependent eicosanoid biosynthesis. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:10783127 |
Cai Y et al. | Bronchial mast cells are the dominating LTC4S-expressing cells in aspirin-tolerant asthma. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12816731 |
Hamasaki Y et al. | Inhibition by dexamethasone of retinoic acid-induced enhancement of leukotriene C4 synthesis in rat basophilic leukemia-1 cells. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:8018338 |
Lay JC et al. | Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10100994 |
Vieira-de-Abreu A et al. | Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene Câ‚„-synthesizing lipid bodies. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:20539011 |
Dent G et al. | Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9448055 |
Nagata M et al. | Granulocyte macrophage colony-stimulating factor augments ICAM-1 and VCAM-1 activation of eosinophil function. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9651192 |
Funayama T et al. | Role of Leukotriene-degrading enzymes in pulmonary response to antigen infusion in sensitized guinea pigs in vivo. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8703483 |
Vieira-de-Abreu A et al. | Allergic challenge-elicited lipid bodies compartmentalize in vivo leukotriene C4 synthesis within eosinophils. | 2005 | Am. J. Respir. Cell Mol. Biol. | pmid:15947420 |
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Burghardt JS et al. | Lipid mediators in oxygen-induced airway remodeling and hyperresponsiveness in newborn rats. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8887572 |
Hasday JD et al. | Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10764316 |
Yamaya M et al. | Epithelial modulation of leukotriene-C4-induced human tracheal smooth muscle contraction. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7881688 |