LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Suzuki R and Freed AN | Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11779726 |
| Macfarlane AJ et al. | Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10806153 |
| Burghardt JS et al. | Lipid mediators in oxygen-induced airway remodeling and hyperresponsiveness in newborn rats. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8887572 |
| Hasday JD et al. | Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10764316 |
| Yamaya M et al. | Epithelial modulation of leukotriene-C4-induced human tracheal smooth muscle contraction. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7881688 |
| Myers SI and Hernandez R | Leukotriene C4 regulation of splanchnic blood flow during ischemia. | 1994 | Am. J. Surg. | pmid:8209929 |
| Lester GD and Rice BL | Effects of leukotriene C4 on the bioelectric properties and ion transport of equine tracheal epithelium. | 2012 | Am. J. Vet. Res. | pmid:23176432 |
| Westcott JY et al. | Inactivation of leukotriene C4 in the airways and subsequent urinary leukotriene E4 excretion in normal and asthmatic subjects. | 1993 | Am. Rev. Respir. Dis. | pmid:7694531 |
| Tsikas D et al. | Catalytic hydrogenation of leukotriene B4 enhances sensitivity and specificity of gas chromatography-tandem mass spectrometry techniques and enables simultaneous analysis with cysteinyl leukotrienes in biological fluids. | 1996 | Anal. Biochem. | pmid:8619486 |
| Wickham S et al. | Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. | 2011 | Anal. Biochem. | pmid:21447318 |
| Tabas LB and Dantzig AH | A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles. | 2002 | Anal. Biochem. | pmid:12413474 |
| Wiklund CU et al. | Interactions of volatile anesthetics with cholinergic, tachykinin, and leukotriene mechanisms in isolated Guinea pig bronchial smooth muscle. | 2002 | Anesth. Analg. | pmid:12456432 |
| Bölke E et al. | Changes of gut barrier function during anesthesia and cardiac surgery. | 2001 | Angiology | pmid:11515987 |
| Gentile DA et al. | Elevations of local leukotriene C4 levels during viral upper respiratory tract infections. | 2003 | Ann. Allergy Asthma Immunol. | pmid:14533659 |
| Hamasaki Y et al. | Inhibition of leukotriene synthesis by azelastine. | 1996 | Ann. Allergy Asthma Immunol. | pmid:8630722 |
| Takao A et al. | Inhibitory effects of azelastine hydrochloride in alcohol-induced asthma. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10227338 |
| Moneret-Vautrin DA et al. | Human basophil activation measured by CD63 expression and LTC4 release in IgE-mediated food allergy. | 1999 | Ann. Allergy Asthma Immunol. | pmid:9988204 |
| el-Ahmady O et al. | Elevated concentrations of interleukins and leukotriene in response to Mycobacterium tuberculosis infection. | 1997 | Ann. Clin. Biochem. | pmid:9133249 |
| Laviolette M et al. | Effects of inhaled steroids on blood eosinophils in moderate asthma. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8031001 |
| Maclouf J et al. | Leukotriene C4 formation by transcellular biosynthesis. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8017763 |
| Mayatepek E et al. | A patient with neurological symptoms and abnormal leukotriene metabolism: a new defect in leukotriene biosynthesis. | 2005 | Ann. Neurol. | pmid:16315285 |
| Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
| Ganbo T et al. | Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. | 1995 | Ann. Otol. Rhinol. Laryngol. | pmid:7872607 |
| Abe M et al. | A novel method for preserving human lungs using a super-cooling system. | 2006 | Ann. Thorac. Surg. | pmid:16928543 |
| Hoopes C | Invited commentary. | 2006 | Ann. Thorac. Surg. | pmid:16928544 |
| Cole SP | Targeting multidrug resistance protein 1 (MRP1, ABCC1): past, present, and future. | 2014 | Annu. Rev. Pharmacol. Toxicol. | pmid:24050699 |
| Ding GY et al. | Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles. | 1999 Jul-Aug | Anticancer Res. | pmid:10652618 |
| Wang J et al. | Does leukotriene affect intracellular glutathione redox state in cultured human airway epithelial cells? | 2008 | Antioxid. Redox Signal. | pmid:18199004 |
| Engin A et al. | Regulation of fibrogenesis during the early phase of common bile duct obstruction. | 2006 | ANZ J Surg | pmid:16813633 |
| Nishida M et al. | Lack of active lung anaphylaxis in congenitally mast cell-deficient Ws/Ws rats sensitized with the nematode Nippostrongylus brasiliensis. | 1998 | APMIS | pmid:9740510 |
| Skazik C et al. | Active transport of contact allergens in human monocyte-derived dendritic cells is mediated by multidrug resistance related proteins. | 2011 | Arch. Biochem. Biophys. | pmid:21284934 |
| Miller LA et al. | Glutathione, S-substituted glutathiones, and leukotriene C4 as substrates for peptidylglycine alpha-amidating monooxygenase. | 2003 | Arch. Biochem. Biophys. | pmid:12646261 |
| Reddanna P et al. | Carboxypeptidase A-catalyzed direct conversion of leukotriene C4 to leukotriene F4. | 2003 | Arch. Biochem. Biophys. | pmid:12729612 |
| Westcott JY et al. | Inactivation of peptidoleukotrienes in the isolated perfused rat lung. | 1993 | Arch. Biochem. Biophys. | pmid:7692821 |
| Schauer U et al. | Blood eosinophils, leukotriene C4 generation, and bronchial hyperreactivity in formerly preterm infants. | 1994 | Arch. Dis. Child. | pmid:7726609 |
| Sampson AP et al. | Persistent increase in plasma and urinary leukotrienes after acute asthma. | 1995 | Arch. Dis. Child. | pmid:7492159 |
| Chavez J et al. | Interactions between leukotriene C4 and interleukin 13 signaling pathways in a mouse model of airway disease. | 2006 | Arch. Pathol. Lab. Med. | pmid:16594735 |
| Kim SJ et al. | Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2006 | Arch. Pharm. Res. | pmid:17121182 |
| Choi YH et al. | Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms. | 2006 | Arch. Pharm. Res. | pmid:16681034 |
| Son MJ et al. | Naturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2006 | Arch. Pharm. Res. | pmid:16681032 |
| Yang JH et al. | Anti-allergic activity of an ethanol extract from Salviae miltiorrhiza. | 2008 | Arch. Pharm. Res. | pmid:19099230 |
| Jin M et al. | Anti-inflammatory activity of 6-hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of yam (Dioscorea batatas) through inhibition of prostaglandin Dâ‚‚ and leukotriene Câ‚„ production in mouse bone marrow-derived mast cells. | 2011 | Arch. Pharm. Res. | pmid:21975811 |
| Zheng MS et al. | Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity. | 2008 | Arch. Pharm. Res. | pmid:18409044 |
| Moon TC et al. | The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2008 | Arch. Pharm. Res. | pmid:18365692 |
| Ra C | [IGE-FCepsilonRI-mast cell paradigm in allergy]. | 2006 | Arerugi | pmid:16718997 |
| Ito R et al. | [Effect of pranlukast on histamine release and leukotriene c4 (ltc4) generation from human peripheral basophils]. | 2004 | Arerugi | pmid:14762327 |
| Kobayashi S et al. | [Inhibitory effect of ONO-1078, a novel leukotriene receptor antagonist, on human peripheral blood eosinophils]. | 1996 | Arerugi | pmid:8990528 |
| Kawashima T et al. | [Inhibitory effect of AS-35. a novel antiallergic drug, on chemical mediator release from human eosinophils]. | 1994 | Arerugi | pmid:7887808 |
| Mita H et al. | [Release of chemical mediators in the conjunctival lavage fluids after eye provocation with allergen or compound 48/80]. | 1994 | Arerugi | pmid:7526828 |
| Bäck M | Cysteinyl-leukotrienes in cerebrovascular disease: angels and demons? | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18421005 |