LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Phlebitis D010689 1 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Cestode Infections D002590 3 associated lipids
Hyperbilirubinemia, Hereditary D006933 3 associated lipids
Neointima D058426 3 associated lipids
Mesenteric Vascular Occlusion D008641 4 associated lipids
Eosinophilia D004802 4 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Picornaviridae Infections D010850 4 associated lipids
Status Asthmaticus D013224 4 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Periapical Periodontitis D010485 6 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Ear Diseases D004427 7 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Lee TK et al. N-glycosylation controls functional activity of Oatp1, an organic anion transporter. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12702494
Hattori Y et al. Gastric mucosal protection against ethanol by EP2 and EP4 signaling through the inhibition of leukotriene C4 production. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17947453
Liu P et al. Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12531730
Sano A et al. Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA(2). 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11557588
Serio KJ et al. TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16980379
Vargaftig BB and Singer M Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12794006
Kingham PJ et al. Adhesion-dependent interactions between eosinophils and cholinergic nerves. 2002 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12003778
Sawatzky DA et al. Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation. 2002 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12003784
Oliveira SH et al. SCF-induced airway hyperreactivity is dependent on leukotriene production. 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11350804
Muñoz NM et al. Augmentation of LTC(4) synthesis in human eosinophils caused by CD3-stimulated Th2-like cells in vitro. 2000 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:10835322
Nagase T et al. A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12505870
Vargaftig BB and Singer M Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12388339
Miller DS et al. Xenobiotic efflux pumps in isolated fish brain capillaries. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11742838
Reichel V et al. Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus. 2008 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:18650317
Downey P et al. Renal concentrating defect in mice lacking group IV cytosolic phospholipase A(2). 2001 Am. J. Physiol. Renal Physiol. pmid:11249852
Perng DW et al. Leukotriene C4 induces TGF-beta1 production in airway epithelium via p38 kinase pathway. 2006 Am. J. Respir. Cell Mol. Biol. pmid:16179583
Sanchez Mejia RO et al. Matrix-associated transforming growth factor-beta1 primes mouse bone marrow-derived mast cells for increased high-affinity Fc receptor for immunoglobulin E-dependent eicosanoid biosynthesis. 2000 Am. J. Respir. Cell Mol. Biol. pmid:10783127
Lay JC et al. Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. 1999 Am. J. Respir. Cell Mol. Biol. pmid:10100994
Vieira-de-Abreu A et al. Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene Câ‚„-synthesizing lipid bodies. 2011 Am. J. Respir. Cell Mol. Biol. pmid:20539011
Funayama T et al. Role of Leukotriene-degrading enzymes in pulmonary response to antigen infusion in sensitized guinea pigs in vivo. 1996 Am. J. Respir. Cell Mol. Biol. pmid:8703483