| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Acute-Phase Reaction | D000210 | 12 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Asbestosis | D001195 | 8 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Cholestasis, Extrahepatic | D001651 | 7 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Cestode Infections | D002590 | 3 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Common Bile Duct Diseases | D003137 | 3 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Venkatachalam TK et al. | Substituted heterocyclic thiourea compounds as a new class of anti-allergic agents inhibiting IgE/Fc epsilon RI receptor mediated mast cell leukotriene release. | 2003 | Bioorg. Med. Chem. | pmid:12614897 |
| Plath KE et al. | Calcineurin antagonists differentially affect mediator secretion, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases from immunologically activated human basophils. | 2003 | Clin. Exp. Allergy | pmid:12614449 |
| Kwak WJ et al. | Papyriflavonol A from Broussonetia papyrifera inhibits the passive cutaneous anaphylaxis reaction and has a secretory phospholipase A2-inhibitory activity. | 2003 | Biol. Pharm. Bull. | pmid:12612436 |
| Mizutani N | [Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms]. | 2003 | Yakugaku Zasshi | pmid:12607939 |
| Wang DY et al. | The upper and lower airway responses to nasal challenge with house-dust mite Blomia tropicalis. | 2003 | Allergy | pmid:12580812 |
| Serio KJ et al. | Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1. | 2003 | J. Immunol. | pmid:12574384 |
| Venkatachalam TK et al. | Inhibition of mast cell leukotriene release by thiourea derivatives. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12565956 |
| Bellou A et al. | Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock. | 2003 | Shock | pmid:12558148 |
| Mastalerz L et al. | Clinical and genetic features underlying the response of patients with bronchial asthma to treatment with a leukotriene receptor antagonist. | 2002 | Eur. J. Clin. Invest. | pmid:12534456 |
| Liu P et al. | Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12531730 |
| Tedla N et al. | Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12529506 |
| Chen ZS et al. | Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). | 2003 | Mol. Pharmacol. | pmid:12527806 |
| Ma L et al. | Identification and characterization of the canine multidrug resistance-associated protein. | 2002 | Mol. Cancer Ther. | pmid:12516967 |
| Nagase T et al. | A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12505870 |
| Yang SH et al. | The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs. | 2002 | Int. Immunopharmacol. | pmid:12469937 |
| Walch L et al. | Pharmacological evidence for a novel cysteinyl-leukotriene receptor subtype in human pulmonary artery smooth muscle. | 2002 | Br. J. Pharmacol. | pmid:12466244 |
| Wiklund CU et al. | Interactions of volatile anesthetics with cholinergic, tachykinin, and leukotriene mechanisms in isolated Guinea pig bronchial smooth muscle. | 2002 | Anesth. Analg. | pmid:12456432 |
| Oliveira SH et al. | Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis. | 2002 | Blood | pmid:12453875 |
| Ren XQ et al. | A positively charged amino acid proximal to the C-terminus of TM17 of MRP1 is indispensable for GSH-dependent binding of substrates and for transport of LTC4. | 2002 | Biochemistry | pmid:12450376 |
| Evans JF | Cysteinyl leukotriene receptors. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432945 |
| Uemura M et al. | Cysteinyl leukotrienes in the bile of patients with obstructive jaundice. | 2002 | J. Gastroenterol. | pmid:12424566 |
| Belinsky MG et al. | Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). | 2002 | Cancer Res. | pmid:12414644 |
| Tabas LB and Dantzig AH | A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles. | 2002 | Anal. Biochem. | pmid:12413474 |
| Lee SH and Altenberg GA | Transport of leukotriene C4 by a cysteine-less multidrug resistance protein 1 (MRP1). | 2003 | Biochem. J. | pmid:12398766 |
| Hashimoto K et al. | Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome. | 2002 | Hepatology | pmid:12395335 |
| Koike K et al. | Multiple membrane-associated tryptophan residues contribute to the transport activity and substrate specificity of the human multidrug resistance protein, MRP1. | 2002 | J. Biol. Chem. | pmid:12388549 |
| Vargaftig BB and Singer M | Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12388339 |
| Keitel V et al. | A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2). | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12388192 |
| Oleschuk CJ et al. | Substitution of Trp1242 of TM17 alters substrate specificity of human multidrug resistance protein 3. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12388190 |
| Liu S et al. | Neuroimmune interactions in guinea pig stomach and small intestine. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12388180 |
| Tsuruoka S et al. | Functional analysis of ABCA8, a new drug transporter. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12379217 |
| ten Hove T et al. | Differential susceptibility of multidrug resistance protein-1 deficient mice to DSS and TNBS-induced colitis. | 2002 | Dig. Dis. Sci. | pmid:12353855 |
| Nobata K et al. | Alpha(1L)-, but not alpha(1H)-, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivo. | 2002 | Eur. J. Pharmacol. | pmid:12323390 |
| Suzuki Y et al. | Silver activates calcium signals in rat basophilic leukemia-2H3 mast cells by a mechanism that differs from the Fc epsilon RI-activated response. | 2002 | J. Immunol. | pmid:12244196 |
| Bandeira-Melo C et al. | Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. | 2002 | J. Exp. Med. | pmid:12235216 |
| Yang Y et al. | Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1. | 2002 | J. Biol. Chem. | pmid:12235150 |
| Hagmann W et al. | Reconstitution of transport-active multidrug resistance protein 2 (MRP2; ABCC2) in proteoliposomes. | 2002 | Biol. Chem. | pmid:12222674 |
| Gebhardt T et al. | Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release. | 2002 | Eur. J. Immunol. | pmid:12209644 |
| Haimeur A et al. | Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity. | 2002 | J. Biol. Chem. | pmid:12186871 |
| Arango P and Kountakis SE | Presence of cysteinyl leukotrienes in asthmatic patients with chronic sinusitis. | 2002 | Laryngoscope | pmid:12169896 |
| Ohashi M et al. | Effects of phalloidin on the biliary excretion of cholephilic compounds in rats. | 2002 | Pharmacology | pmid:12169763 |
| Hashizume K and Black KL | Increased endothelial vesicular transport correlates with increased blood-tumor barrier permeability induced by bradykinin and leukotriene C4. | 2002 | J. Neuropathol. Exp. Neurol. | pmid:12152787 |
| Gibbs BF et al. | Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization. | 2002 | J. Leukoc. Biol. | pmid:12149431 |
| Thomas LL et al. | Immobilized lactoferrin is a stimulus for eosinophil activation. | 2002 | J. Immunol. | pmid:12097406 |
| Bandeira-Melo C et al. | Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. | 2002 | J. Allergy Clin. Immunol. | pmid:12063527 |
| Fernández SB et al. | Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells. | 2002 | J. Biol. Chem. | pmid:12060660 |
| Oliveira SH et al. | Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. | 2002 | J. Leukoc. Biol. | pmid:12050188 |
| Conrad S et al. | A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance. | 2002 | Pharmacogenetics | pmid:12042670 |
| Mao Q et al. | GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain. | 2002 | J. Biol. Chem. | pmid:12034727 |
| Christmas P et al. | Membrane localization and topology of leukotriene C4 synthase. | 2002 | J. Biol. Chem. | pmid:12023288 |
| de las Heras B et al. | Effects of six diterpenes on macrophage eicosanoid biosynthesis. | 2001 | Life Sci. | pmid:12005260 |
| Sawatzky DA et al. | Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation. | 2002 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12003784 |
| Kingham PJ et al. | Adhesion-dependent interactions between eosinophils and cholinergic nerves. | 2002 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12003778 |
| Ravasi S et al. | Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. | 2002 | Biochem. Pharmacol. | pmid:11996896 |
| Kolaczkowska E et al. | Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes. | 2002 | Inflammation | pmid:11989789 |
| Bandeira-Melo C et al. | IL-16 promotes leukotriene C(4) and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling. | 2002 | J. Immunol. | pmid:11971026 |
| Norman BH et al. | Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1). | 2002 | Bioorg. Med. Chem. Lett. | pmid:11958985 |
| Ahamed J and Ali H | Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. | 2002 | J. Biol. Chem. | pmid:11934880 |
| Maekawa A et al. | Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. | 2002 | J. Biol. Chem. | pmid:11932261 |
| Zhang DW et al. | Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17. | 2002 | J. Biol. Chem. | pmid:11925441 |
| Neu IS et al. | Leukotrienes in patients with clinically active multiple sclerosis. | 2002 | Acta Neurol. Scand. | pmid:11903112 |
| Guo A et al. | Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). | 2002 | Drug Metab. Dispos. | pmid:11901101 |
| Jedlitschky G and Keppler D | Transport of leukotriene C4 and structurally related conjugates. | 2002 | Vitam. Horm. | pmid:11898391 |
| Iliás A et al. | Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). | 2002 | J. Biol. Chem. | pmid:11880368 |
| Küsters S et al. | Effects of antihistamines on leukotriene and cytokine release from dispersed nasal polyp cells. | 2002 | Arzneimittelforschung | pmid:11878205 |
| Bäck M et al. | Modulation of vascular tone and reactivity by nitric oxide in porcine pulmonary arteries and veins. | 2002 | Acta Physiol. Scand. | pmid:11851592 |
| Sakata K and Bäck M | Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma. | 2002 | Eur. J. Pharmacol. | pmid:11834255 |
| Shon YH et al. | Effect of Astragali radix extract on lipopolysaccharide-induced inflammation in human amnion. | 2002 | Biol. Pharm. Bull. | pmid:11824562 |
| Bermejo BP et al. | Sesquiterpenes from Jasonia glutinosa: in vitro anti-inflammatory activity. | 2002 | Biol. Pharm. Bull. | pmid:11824534 |
| Fukuishi N et al. | Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. | 2001 | Phytomedicine | pmid:11824521 |
| Chrubasik S et al. | Harpagophytum extracts. | 2002 | Clin. Pharmacol. Ther. | pmid:11823764 |
| Suzuki R and Freed AN | Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11779726 |
| Wang J et al. | [The effects of resuscitation with hypertonic saline solution on the postburn pulmonary injury in scalded dogs]. | 2001 | Zhonghua Shao Shang Za Zhi | pmid:11774813 |
| Malaviya R and Uckun FM | Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells. | 2002 | J. Immunol. | pmid:11751988 |
| Miller DS et al. | Xenobiotic efflux pumps in isolated fish brain capillaries. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11742838 |
| Miura K et al. | Localizing a control region in the pathway to leukotriene C(4) secretion following stimulation of human basophils with anti-IgE antibody. | 2001 | J. Immunol. | pmid:11739523 |
| Fernández MA et al. | New insights into the mechanism of action of the anti-inflammatory triterpene lupeol. | 2001 | J. Pharm. Pharmacol. | pmid:11732756 |
| Martin V et al. | Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors. | 2001 | Biochem. Pharmacol. | pmid:11705452 |
| Bölke E et al. | Inflammatory response during abdominal and thyroid surgery: a prospective clinical trial on mediator release. | 2001 | Shock | pmid:11699069 |
| Miura K et al. | Piceatannol is an effective inhibitor of IgE-mediated secretion from human basophils but is neither selective for this receptor nor acts on syk kinase at concentrations where mediator release inhibition occurs. | 2001 | Clin. Exp. Allergy | pmid:11696049 |
| Terlouw SA et al. | Role of multidrug resistance protein 2 (MRP2) in glutathione-bimane efflux from Caco-2 and rat renal proximal tubule cells. | 2001 | Br. J. Pharmacol. | pmid:11682439 |
| Ohno N et al. | Prognostic significance of multidrug resistance protein in adult T-cell leukemia. | 2001 | Clin. Cancer Res. | pmid:11595704 |
| Duffy SM et al. | Resting and activation-dependent ion channels in human mast cells. | 2001 | J. Immunol. | pmid:11591748 |
| Hui Y et al. | The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. | 2001 | J. Biol. Chem. | pmid:11591709 |
| Schroeder JT et al. | Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. | 2001 | Clin. Exp. Allergy | pmid:11591186 |
| Kamohara M et al. | Functional characterization of cysteinyl leukotriene CysLT(2) receptor on human coronary artery smooth muscle cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11587533 |
| Thomas LL et al. | Peptide-based analysis of amino acid sequences important to the biological activity of eosinophil granule major basic protein. | 2001 | Immunol. Lett. | pmid:11578692 |
| Sano A et al. | Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA(2). | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11557588 |
| Malaviya R and Uckun FM | Leflunomide metabolite analogue alpha-cyano-beta-hydroxy-beta-methyl-N-[3-(trifluoromethyl)phenyl]propenamide inhibits IgE/FcepsilonRI receptor-mediated mast cell leukotriene release and allergic asthma in mice. | 2001 Sep-Oct | Am J Ther | pmid:11550070 |
| Tornhamre S et al. | Inhibitory effects of helenalin and related compounds on 5-lipoxygenase and leukotriene C(4) synthase in human blood cells. | 2001 | Biochem. Pharmacol. | pmid:11543725 |
| Wehner J and Neuber K | Staphylococcus aureus enterotoxins induce histamine and leukotriene release in patients with atopic eczema. | 2001 | Br. J. Dermatol. | pmid:11531797 |
| Abad MJ et al. | Effects of furocoumarins from Cachrys trifida on some macrophage functions. | 2001 | J. Pharm. Pharmacol. | pmid:11518028 |
| Bölke E et al. | Changes of gut barrier function during anesthesia and cardiac surgery. | 2001 | Angiology | pmid:11515987 |
| Qian YM et al. | Characterization of binding of leukotriene C4 by human multidrug resistance protein 1: evidence of differential interactions with NH2- and COOH-proximal halves of the protein. | 2001 | J. Biol. Chem. | pmid:11507101 |
| Aoki M et al. | Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11504812 |
| Ito K et al. | Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. | 2001 | J. Biol. Chem. | pmid:11500505 |
| Miura K et al. | Differences in functional consequences and signal transduction induced by IL-3, IL-5, and nerve growth factor in human basophils. | 2001 | J. Immunol. | pmid:11490016 |
| Bäck M et al. | An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea. | 2001 | Br. J. Pharmacol. | pmid:11487525 |
| Strenzke N et al. | Mercuric chloride enhances immunoglobulin E-dependent mediator release from human basophils. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11485386 |
| Falcón-Pérez JM et al. | Domain interactions in the yeast ATP binding cassette transporter Ycf1p: intragenic suppressor analysis of mutations in the nucleotide binding domains. | 2001 | J. Bacteriol. | pmid:11466279 |