| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Acute-Phase Reaction | D000210 | 12 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Asbestosis | D001195 | 8 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Cholestasis, Extrahepatic | D001651 | 7 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Cestode Infections | D002590 | 3 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Common Bile Duct Diseases | D003137 | 3 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tanaka H et al. | Biliary excretion of phenolphthalein sulfate in rats. | 2003 | Pharmacology | pmid:12837971 |
| Yang SL et al. | Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. | 2007 | Pharmacology | pmid:17496435 |
| Ionac M et al. | Oxaceprol, an atypical inhibitor of inflammation and joint damage. | 1996 | Pharmacol. Res. | pmid:8971960 |
| Conrad S et al. | A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance. | 2002 | Pharmacogenetics | pmid:12042670 |
| Megaraj V et al. | Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2). | 2011 | Pharmacogenet. Genomics | pmid:21691255 |
| Hirouchi M et al. | Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2. | 2004 | Pharm. Res. | pmid:15180328 |
| Yang JJ et al. | Multidrug resistance protein 1 (MRP1) in rabbit conjunctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection. | 2007 | Pharm. Res. | pmid:17404811 |
| Scheidegger C et al. | Effects of extracts and of individual components from Petasites on prostaglandin synthesis in cultured skin fibroblasts and on leucotriene synthesis in isolated human peripheral leucocytes. | 1998 | Pharm Acta Helv | pmid:9556438 |
| Bakos E and Homolya L | Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1). | 2007 | Pflugers Arch. | pmid:17187268 |
| Tschugguel W et al. | High precision measurement of electrical resistance across endothelial cell monolayers. | 1995 | Pflugers Arch. | pmid:7667075 |
| Ohbayashi H and Yamaki KI | Both inhalant and intravenous uroguanylin inhibit leukotriene C4-induced airway changes. | 2000 | Peptides | pmid:11068092 |
| Ohtsuka Y et al. | Chronic oral antigen exposure induces lymphocyte migration in anaphylactic mouse intestine. | 1998 | Pediatr. Res. | pmid:9803464 |
| Ohtsuka Y et al. | Reducing cell membrane n-6 fatty acids attenuate mucosal damage in food-sensitive enteropathy in mice. | 1997 | Pediatr. Res. | pmid:9396566 |
| Mayatepek E et al. | Impaired synthesis of lipoxygenase products in glutathione synthetase deficiency. | 1994 | Pediatr. Res. | pmid:8190517 |
| Yakubu MA et al. | Hematoma-induced enhanced cerebral vasoconstrictions to leukotriene C4 and endothelin-1 in piglets: role of prostanoids. | 1995 | Pediatr. Res. | pmid:7478789 |
| Pintos-Morell G et al. | Altered leukotriene generation in leukocytes from cystinotic children. | 1994 | Pediatr. Res. | pmid:7877883 |
| Shimizu T et al. | Inhibitory effects of theophylline, terbutaline, and hydrocortisone on leukotriene B4 and C4 generation by human leukocytes in vitro. | 1994 | Pediatr. Pulmonol. | pmid:7800427 |
| Matsuo M et al. | Leukotriene B4 and C4 in cerebrospinal fluid from children with meningitis and febrile seizures. | 1996 | Pediatr. Neurol. | pmid:8703223 |
| Shimizu T et al. | Leukotriene B4 and C4 generation by blood leukocytes after ex vivo stimulation by Ca-ionophore and opsonized zymosan in children with atopic dermatitis. | 1994 | Pediatr Allergy Immunol | pmid:8087194 |
| Kopp MV et al. | Omalizumab (Xolair) in children with seasonal allergic rhinitis: leukotriene release as a potential in vitro parameter to monitor therapeutic effects. | 2007 | Pediatr Allergy Immunol | pmid:17680911 |