Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Loe DW et al. | ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. | 1996 | J. Biol. Chem. | pmid:8621644 |
Wilborn J et al. | Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. | 1996 | J. Clin. Invest. | pmid:8621765 |
Weber M et al. | Deletion of the NH2-terminal residue converts monocyte chemotactic protein 1 from an activator of basophil mediator release to an eosinophil chemoattractant. | 1996 | J. Exp. Med. | pmid:8627182 |
Meltzer SS et al. | Inhibition of exercise-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8630575 |
Hamasaki Y et al. | Inhibition of leukotriene synthesis by azelastine. | 1996 | Ann. Allergy Asthma Immunol. | pmid:8630722 |
Tang DG et al. | Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8643560 |
Genovese A et al. | Role of mast cells, basophils and their mediators in adverse reactions to general anesthetics and radiocontrast media. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645973 |
Büchler M et al. | cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. | 1996 | J. Biol. Chem. | pmid:8662992 |
Leier I et al. | ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. | 1996 | Biochem. J. | pmid:8670053 |
de Paulis A et al. | Human synovial mast cells. I. Ultrastructural in situ and in vitro immunologic characterization. | 1996 | Arthritis Rheum. | pmid:8670335 |
Takase B et al. | Change of plasma leukotriene C4 during myocardial ischemia in humans. | 1996 | Clin Cardiol | pmid:8674256 |
Ruf G et al. | Aminoterminal propeptide of type III procollagen: a marker of hepatic fibrosis after bile duct obstruction in the monkey. | 1996 Jan-Feb | Hepatogastroenterology | pmid:8682446 |
Shraga-Levine Z et al. | Arachidonic acid and lipoxygenase products stimulate protein kinase C beta mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin-releasing hormone action. | 1996 | Biochem. J. | pmid:8687415 |
Papayianni A et al. | Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. | 1996 | J. Immunol. | pmid:8690917 |
Paul S et al. | ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8692921 |
Przylipiak A et al. | Role of leukotriene C4 in follicle-stimulating hormone (FSH) secretion in female rat pituitary. | 1996 | Gynecol. Endocrinol. | pmid:8701793 |
Matsuo M et al. | Leukotriene B4 and C4 in cerebrospinal fluid from children with meningitis and febrile seizures. | 1996 | Pediatr. Neurol. | pmid:8703223 |
Sainte-Laudy J et al. | [Importance of the leukotriene C4 liberation test for the diagnosis of drug allergy (preliminary results)]. | 1996 | Allerg Immunol (Paris) | pmid:8703308 |
Funayama T et al. | Role of Leukotriene-degrading enzymes in pulmonary response to antigen infusion in sensitized guinea pigs in vivo. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8703483 |
Shindo K et al. | Priming effect of platelet activating factor on leukotriene C4 from stimulated eosinophils of asthmatic patients. | 1996 | Thorax | pmid:8711647 |
Zuberbier T et al. | Histamine releasability of basophils and skin mast cells in chronic urticaria. | 1996 | Allergy | pmid:8721524 |
Daffonchio L et al. | Protective activity of ketoprofen lysine salt against the pulmonary effects induced by bradykinin in guinea-pigs. | 1996 | Inflamm. Res. | pmid:8737750 |
Shichinohe K et al. | Effect of M-711 on experimental skin reactions induced by chemical mediators in rats. | 1996 | J. Vet. Med. Sci. | pmid:8741601 |
Kristjánsson S et al. | Leukotriene B4 and C4 generation by human leukocytes after ex vivo stimulation with Ca-ionophore and opsonized zymosan in children with atopic asthma. | 1995 | Pediatr Allergy Immunol | pmid:8750311 |
Patella V et al. | Oxatomide inhibits the release of proinflammatory mediators from human basophils and mast cells. | 1996 | Int. Arch. Allergy Immunol. | pmid:8753840 |
Horsmanheimo L et al. | Histamine and leukotriene C4 release in cutaneous mosquito-bite reactions. | 1996 | J. Allergy Clin. Immunol. | pmid:8757218 |
Zhang H et al. | [Study on the effect and mechanism of qinggan xiehuo decoction in treatment of endotoxin-induced uveitis in rabbits]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8762423 |
de Paulis A et al. | Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. | 1996 | J. Allergy Clin. Immunol. | pmid:8765829 |
Ganbo T et al. | Leukotriene C4 inhibits ciliary activity in the presence of gamma-glutamyl transpeptidase. | 1996 | Am. J. Physiol. | pmid:8770059 |
Lam BK et al. | Leukotriene C4 synthase. | 1995 | J Lipid Mediat Cell Signal | pmid:8777577 |
He L and Zhu J | Distinguishing antemortem from postmortem injuries by LTB4 quantification. | 1996 | Forensic Sci. Int. | pmid:8784990 |
Brock TG et al. | Effects of granulocyte-macrophage colony-stimulating factor on eicosanoid production by mononuclear phagocytes. | 1996 | J. Immunol. | pmid:8786314 |
Batirel HF et al. | The effect of aqueous garlic extract on the levels of arachidonic acid metabolites (leukotriene C4 and prostaglandin E2) in rat forebrain after ischemia-reperfusion injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804127 |
Hackshaw KV et al. | Environmental influences on fatty acid composition of membranes from autoimmune MRL lpr/lpr mice. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804129 |
Chuman Y et al. | Characterization of the ATP-dependent LTC4 transporter in cisplatin-resistant human KB cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806607 |
Westcott JY et al. | Arachidonate-induced eicosanoid synthesis in RBL-2H3 cells: stimulation with antigen or A23187 induces prolonged activation of 5-lipoxygenase. | 1996 | Biochim. Biophys. Acta | pmid:8816855 |
Tominaga M et al. | ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819486 |
Herron DK et al. | Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. | 1995 | J Mol Graph | pmid:8820302 |
Ono S et al. | [Role of peptide leukotrienes in monocrotaline-induced lung disease]. | 1995 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8821996 |
Crampette L et al. | Inhibition of mediator and cytokine release from dispersed nasal polyp cells by terfenadine. | 1996 | Allergy | pmid:8836342 |
Tanaka H et al. | The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. | 1995 Nov-Dec | Prostaglandins | pmid:8838238 |
Tenor H et al. | Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. | 1996 | Br. J. Pharmacol. | pmid:8842438 |
Hong JT et al. | Effect of phenobarbital and the peroxisome proliferator ciprofibrate on gamma-Glutamyltranspeptidase activity and leukotriene C4 concentration in cultured rat hepatocytes. | 1995 | J. Biochem. Toxicol. | pmid:8847705 |
Abe M et al. | Evaluation of the effects of steroids on experimental septic lung injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8848431 |
Fukai F et al. | Transcellular biosynthesis of cysteinyl leukotrienes by Kupffer cell-hepatocyte cooperation in rat liver. | 1996 | Cell Biol. Int. | pmid:8858827 |
Jafarian A et al. | Effects of RS-albuterol on the development of antigen-mediated airway hyperreactivity in guinea pigs. | 1996 | Clin Rev Allergy Immunol | pmid:8866174 |
Keppler D et al. | The function of the multidrug resistance proteins (MRP and cMRP) in drug conjugate transport and hepatobiliary excretion. | 1996 | Adv. Enzyme Regul. | pmid:8869738 |
Tool AT et al. | The effect of salmeterol and nimesulide on chemotaxis and synthesis of PAF and LTC4 by human eosinophils. | 1996 | Eur Respir J Suppl | pmid:8871060 |
Henderson WR et al. | The importance of leukotrienes in airway inflammation in a mouse model of asthma. | 1996 | J. Exp. Med. | pmid:8879219 |
Paul S et al. | Structure and in vitro substrate specificity of the murine multidrug resistance-associated protein. | 1996 | Biochemistry | pmid:8885844 |