Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Falcón-Pérez JM et al. | Functional domain analysis of the yeast ABC transporter Ycf1p by site-directed mutagenesis. | 1999 | J. Biol. Chem. | pmid:10438540 |
Campbell EM et al. | Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. | 1999 | J. Immunol. | pmid:10438957 |
Kawabe T et al. | Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). | 1999 | FEBS Lett. | pmid:10456333 |
Sarau HM et al. | Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. | 1999 | Mol. Pharmacol. | pmid:10462554 |
Nakasato H et al. | Prevention of severe premenstrual asthma attacks by leukotriene receptor antagonist. | 1999 | J. Allergy Clin. Immunol. | pmid:10482831 |
Hagmann W et al. | Purification of the human apical conjugate export pump MRP2 reconstitution and functional characterization as substrate-stimulated ATPase. | 1999 | Eur. J. Biochem. | pmid:10491184 |
Rao AM et al. | Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils. | 1999 | Neurochem. Res. | pmid:10492517 |
Van Aubel RA et al. | Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells. | 1999 | Mol. Pharmacol. | pmid:10496953 |
Schmidt D et al. | Passive sensitization of human airways increases responsiveness to leukotriene C4. | 1999 | Eur. Respir. J. | pmid:10515407 |
Muñoz NM et al. | Augmentation of eosinophil degranulation and LTC(4) secretion by integrin-mediated endothelial cell adhesion. | 1999 | Am. J. Physiol. | pmid:10516222 |
May A et al. | Means of increasing sensitivity of an in vitro diagnostic test for aspirin intolerance. | 1999 | Clin. Exp. Allergy | pmid:10520062 |
Ko JK and Cho CH | Co-regulation of mucosal nitric oxide and prostaglandin in gastric adaptive cytoprotection. | 1999 | Inflamm. Res. | pmid:10522801 |
Lankisch TO et al. | High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. | 1999 | Eur. J. Cell Biol. | pmid:10535305 |
Mao Q et al. | ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells. | 1999 | Biochim. Biophys. Acta | pmid:10556489 |
Rao AM et al. | CDP-choline: neuroprotection in transient forebrain ischemia of gerbils. | 1999 | J. Neurosci. Res. | pmid:10561698 |
Chen ZS et al. | Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. | 1999 | Mol. Pharmacol. | pmid:10570049 |
Cracowski JL et al. | Functional comparison of the human isolated femoral artery, internal mammary artery, gastroepiploic artery, and saphenous vein. | 1999 | Can. J. Physiol. Pharmacol. | pmid:10588481 |
Norman BH et al. | Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10612603 |
Bandeira-Melo C et al. | Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. | 2000 | J. Immunol. | pmid:10623853 |
Sundkvist E et al. | Leukotriene C(4) (LTC(4)) does not share a cellular efflux mechanism with cGMP: characterisation of cGMP transport by uptake to inside-out vesicles from human erythrocytes. | 2000 | Biochim. Biophys. Acta | pmid:10631301 |