Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Mayatepek E | Leukotriene C4 synthesis deficiency: a member of a probably underdiagnosed new group of neurometabolic diseases. | 2000 | Eur. J. Pediatr. | pmid:11079193 |
Ravasi S et al. | A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma. | 2000 | Mol. Pharmacol. | pmid:10825389 |
Seno K et al. | Pyrrolidine inhibitors of human cytosolic phospholipase A(2). | 2000 | J. Med. Chem. | pmid:10737736 |
Gao M et al. | Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1. | 2000 | J. Biol. Chem. | pmid:10777615 |
Goulet JL et al. | Genetic factors determine the contribution of leukotrienes to acute inflammatory responses. | 2000 | J. Immunol. | pmid:10779800 |
Vidal A et al. | Synthesis of 19-[(2-azido-5-iodo)-benzoyloxy]-LTA4 and enzymatic conversion to the LTC4 analogue. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10762049 |
Mao Q et al. | Functional reconstitution of substrate transport by purified multidrug resistance protein MRP1 (ABCC1) in phospholipid vesicles. | 2000 | J. Biol. Chem. | pmid:10942765 |
Bäck M et al. | Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl-leukotrienes. | 2000 | Eur. J. Pharmacol. | pmid:10936498 |
Loe DW et al. | Structure-activity studies of verapamil analogs that modulate transport of leukotriene C(4) and reduced glutathione by multidrug resistance protein MRP1. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10973801 |
Takasaki J et al. | The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10913337 |
Bossé M et al. | Eosinophil activation status and corticosteroid responsiveness in severe asthma. | 2000 | Int. Arch. Allergy Immunol. | pmid:10899764 |
Dent G et al. | Involvement of protein tyrosine kinases in activation of human eosinophils by platelet-activating factor. | 2000 | Immunology | pmid:10886400 |
Gibbs BF et al. | Ambroxol inhibits IgE-dependent mediator secretion from human skin mast cells. | 2000 | Inflamm. Res. | pmid:10864402 |
Taskila K et al. | Histamine and LTC4 in stinging nettle-induced urticaria. | 2000 | Allergy | pmid:10921474 |
Bowers RC et al. | A novel glutathione containing eicosanoid (FOG7) chemotactic for human granulocytes. | 2000 | J. Biol. Chem. | pmid:10924496 |
Eglite S et al. | Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils. | 2000 | J. Immunol. | pmid:10925305 |
Sainte-Laudy J et al. | Diagnosis of venom allergy by flow cytometry. Correlation with clinical history, skin tests, specific IgE, histamine and leukotriene C4 release. | 2000 | Clin. Exp. Allergy | pmid:10931125 |
Ding GY et al. | Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles. | 1999 Jul-Aug | Anticancer Res. | pmid:10652618 |
Rao AM et al. | Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils. | 1999 | Neurochem. Res. | pmid:10492517 |
Nakasato H et al. | Prevention of severe premenstrual asthma attacks by leukotriene receptor antagonist. | 1999 | J. Allergy Clin. Immunol. | pmid:10482831 |
O'Connor BJ et al. | Selective airway responsiveness in asthma. | 1999 | Trends Pharmacol. Sci. | pmid:10101956 |
Akpek EA et al. | A study of adenosine treatment in experimental acute spinal cord injury. Effect on arachidonic acid metabolites. | 1999 | Spine | pmid:9926381 |
Niinuma K et al. | Primary active transport of organic anions on bile canalicular membrane in humans. | 1999 | Am. J. Physiol. | pmid:10330006 |
Lärfars G et al. | Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. | 1999 | Blood | pmid:9949184 |
Hamasaki Y et al. | Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells. | 1999 | Planta Med. | pmid:10232065 |
Mayatepek E et al. | LTB4 and LTC4 are absent in the cerebrospinal fluid of human immunodeficiency virus type 1-seropositive persons with toxoplasmic encephalitis: evidence for inhibition of 5-lipoxygenase by Toxoplasma gondii. | 1999 | J. Infect. Dis. | pmid:9952384 |
Lay JC et al. | Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10100994 |
Lankisch TO et al. | High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. | 1999 | Eur. J. Cell Biol. | pmid:10535305 |
Sarau HM et al. | Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. | 1999 | Mol. Pharmacol. | pmid:10462554 |
Lynch KR et al. | Characterization of the human cysteinyl leukotriene CysLT1 receptor. | 1999 | Nature | pmid:10391245 |
Cordoba-Rodriguez R et al. | Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393875 |
Hipfner DR et al. | Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein. | 1999 | J. Biol. Chem. | pmid:10336431 |
Rappa G et al. | New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models. | 1999 | Biochem. Pharmacol. | pmid:10413292 |
Kamisako T et al. | Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. | 1999 | Hepatology | pmid:10421658 |
Masereeuw R et al. | Active lucifer yellow secretion in renal proximal tubule: evidence for organic anion transport system crossover. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10215693 |
Bischoff SC et al. | IL-4 enhances proliferation and mediator release in mature human mast cells. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393951 |
Clish CB et al. | Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393980 |
Sano A et al. | Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10351938 |
Kita H et al. | Does IgE bind to and activate eosinophils from patients with allergy? | 1999 | J. Immunol. | pmid:10352312 |
Chen ZS et al. | An enhanced active efflux of CPT-11 and SN-38 in cisplatin-resistant human KB carcinoma cells. | 1999 | Cancer Lett. | pmid:10378768 |
Bannenberg G et al. | Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. | 1999 | J. Biol. Chem. | pmid:9890956 |
Gibbs BF and Grabbe J | Inhibitors of PI 3-kinase and MEK kinase differentially affect mediator secretion from immunologically activated human basophils. | 1999 | J. Leukoc. Biol. | pmid:10380914 |
Irkeç MT et al. | Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. | 1999 | Ocul. Immunol. Inflamm. | pmid:10410873 |
Dantzig AH et al. | Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10411602 |
Mayatepek E et al. | A severely affected infant with absence of cysteinyl leukotrienes in cerebrospinal fluid: further evidence that leukotriene C4-synthesis deficiency is a new neurometabolic disorder. | 1999 | Neuropediatrics | pmid:10222453 |
Takao A et al. | Inhibitory effects of azelastine hydrochloride in alcohol-induced asthma. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10227338 |
Denizot Y et al. | Are lipid mediators implicated in the production of pro- and anti-inflammatory cytokines during cardiopulmonary bypass graft with extracorporeal circulation? | 1999 | Cytokine | pmid:10328869 |
Miura K et al. | Extracellular signal-regulated kinases regulate leukotriene C4 generation, but not histamine release or IL-4 production from human basophils. | 1999 | J. Immunol. | pmid:10201947 |
Mao Q et al. | ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells. | 1999 | Biochim. Biophys. Acta | pmid:10556489 |
Held HD et al. | Characterization of airway and vascular responses in murine lungs. | 1999 | Br. J. Pharmacol. | pmid:10205008 |
Rao AM et al. | CDP-choline: neuroprotection in transient forebrain ischemia of gerbils. | 1999 | J. Neurosci. Res. | pmid:10561698 |
Malaviya R and Uckun FM | Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10208864 |
Norman BH et al. | Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10612603 |
Desplat V et al. | Incorporation and effect of arachidonic acid on the growth of human myeloma cell lines. | 1999 | Mediators Inflamm. | pmid:10704149 |
Chen ZS et al. | Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. | 1999 | Mol. Pharmacol. | pmid:10570049 |
Cracowski JL et al. | Functional comparison of the human isolated femoral artery, internal mammary artery, gastroepiploic artery, and saphenous vein. | 1999 | Can. J. Physiol. Pharmacol. | pmid:10588481 |
Nilsen A et al. | Short-term exposure of rodents to diesel exhausts: usefulness for studies of genotoxic and immunotoxic effects. | 1999 | Chem. Biol. Interact. | pmid:10227576 |
Nakamura T et al. | Direct interaction between a quinoline derivative, MS-209, and multidrug resistance protein (MRP) in human gastric cancer cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10049760 |
Sjölinder M et al. | Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. | 1999 | J. Lipid Res. | pmid:10064732 |
Constable AL et al. | DMSO induction of the leukotriene LTC4 by Lewis rat Schwann cells. | 1999 | J. Neurol. Sci. | pmid:10202977 |
Collin N et al. | [Search for a threshold to distinguish between locoregional and systemic reactions using the histamine liberation value and the LTC4 level]. | 1999 | Allerg Immunol (Paris) | pmid:10070593 |
Miadonna A et al. | Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. | 1999 | Clin. Exp. Allergy | pmid:10383595 |
Sakamoto H et al. | Enhancement of glucuronosyl etoposide transport by glutathione in multidrug resistance-associated protein-overexpressing cells. | 1999 | Cancer Lett. | pmid:10077229 |
Awasthi S et al. | ATP-Dependent colchicine transport by human erythrocyte glutathione conjugate transporter. | 1999 | Toxicol. Appl. Pharmacol. | pmid:10079207 |
McWherter CA et al. | Circular permutation of the granulocyte colony-stimulating factor receptor agonist domain of myelopoietin. | 1999 | Biochemistry | pmid:10194378 |
Carvalho-Tavares J et al. | Assessment of the mechanism of juxtacrine activation and adhesion of leukocytes in liver microcirculation. | 1999 | Am. J. Physiol. | pmid:10198324 |
Renes J et al. | ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. | 1999 | Br. J. Pharmacol. | pmid:10188979 |
Schmidt D et al. | Passive sensitization of human airways increases responsiveness to leukotriene C4. | 1999 | Eur. Respir. J. | pmid:10515407 |
Muñoz NM et al. | Augmentation of eosinophil degranulation and LTC(4) secretion by integrin-mediated endothelial cell adhesion. | 1999 | Am. J. Physiol. | pmid:10516222 |
May A et al. | Means of increasing sensitivity of an in vitro diagnostic test for aspirin intolerance. | 1999 | Clin. Exp. Allergy | pmid:10520062 |
Ko JK and Cho CH | Co-regulation of mucosal nitric oxide and prostaglandin in gastric adaptive cytoprotection. | 1999 | Inflamm. Res. | pmid:10522801 |
Van Aubel RA et al. | Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells. | 1999 | Mol. Pharmacol. | pmid:10496953 |
Hagmann W et al. | Purification of the human apical conjugate export pump MRP2 reconstitution and functional characterization as substrate-stimulated ATPase. | 1999 | Eur. J. Biochem. | pmid:10491184 |
Falcón-Pérez JM et al. | Functional domain analysis of the yeast ABC transporter Ycf1p by site-directed mutagenesis. | 1999 | J. Biol. Chem. | pmid:10438540 |
Campbell EM et al. | Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. | 1999 | J. Immunol. | pmid:10438957 |
Kawabe T et al. | Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). | 1999 | FEBS Lett. | pmid:10456333 |
Vellenga E et al. | Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. | 1999 | Br. J. Pharmacol. | pmid:10385244 |
Stride BD et al. | Localization of a substrate specificity domain in the multidrug resistance protein. | 1999 | J. Biol. Chem. | pmid:10428874 |
Ochensberger B et al. | Regulation of cytokine expression and leukotriene formation in human basophils by growth factors, chemokines and chemotactic agonists. | 1999 | Eur. J. Immunol. | pmid:9933081 |
Tsuruta R et al. | Soluble vascular cell adhesion molecule (VCAM)-Fc fusion protein induces leukotriene C4 secretion in platelet-activating factor-stimulated eosinophils. | 1999 | J. Leukoc. Biol. | pmid:9886248 |
Brock TG et al. | Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils. | 1999 | J. Immunol. | pmid:9973428 |
Urasaki T et al. | Cytosolic phospholipase A2, increased and activated in the eosinophils of patients with hypereosinophilic syndrome in vivo, is involved in the augmented release of leukotriene C4. | 1999 | Inflamm. Res. | pmid:9987681 |
Moneret-Vautrin DA et al. | Human basophil activation measured by CD63 expression and LTC4 release in IgE-mediated food allergy. | 1999 | Ann. Allergy Asthma Immunol. | pmid:9988204 |
Lieberman MW et al. | Gamma-glutamyl leukotrienase cleavage of leukotriene C4. | 1999 | Adv. Exp. Med. Biol. | pmid:10667345 |
Schweitzer P et al. | Cannabinoid modulation of neuronal activity in adult rat hippocampus. | 1999 | Adv. Exp. Med. Biol. | pmid:10667381 |
Herman CA and Luczy-Bachman G | Eicosanoids in the brain of warm- and cold-acclimated bullfrogs. | 1999 | Adv. Exp. Med. Biol. | pmid:10667397 |
Amann R et al. | Eicosanoid release in the endotoxin-primed isolated perfused rat lung and its pharmacological modification. | 1999 | Inflamm. Res. | pmid:10669114 |
Sciuto AM et al. | Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. | 1998 Sep-Oct | J Appl Toxicol | pmid:9804432 |
Bartosz G et al. | Human mast cells secreting leukotriene C4 express the MRP1 gene-encoded conjugate export pump. | 1998 Aug-Sep | Biol. Chem. | pmid:9792445 |
Akman A et al. | Effects of lodoxamide, disodium cromoglycate and fluorometholone on tear leukotriene levels in vernal keratoconjunctivitis. | 1998 | Eye (Lond) | pmid:9683957 |
Schuligoi R et al. | Effects of the cyclooxygenase-2 inhibitor NS-398 on thromboxane and leukotriene synthesis in rat peritoneal cells. | 1998 | Inflamm. Res. | pmid:9657255 |
Geirsson A et al. | Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. | 1998 | J. Cell. Physiol. | pmid:9731750 |
Anadol AZ et al. | Role of endogenous endothelin peptides in intestinal ischemia-reperfusion injury in rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9849655 |
Nishida M et al. | Lack of active lung anaphylaxis in congenitally mast cell-deficient Ws/Ws rats sensitized with the nematode Nippostrongylus brasiliensis. | 1998 | APMIS | pmid:9740510 |
Allen S et al. | Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. | 1998 | Circulation | pmid:9641692 |
Koshino T et al. | Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9642160 |
Peters-Golden M | Cell biology of the 5-lipoxygenase pathway. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9647604 |
Hamasaki Y et al. | Inhibition of leukotriene synthesis by terfenadine in vitro. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654399 |
Chu XY et al. | Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters. | 1998 | Cancer Res. | pmid:9823324 |
Jonsson EW | Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. | 1998 | Acta Physiol Scand Suppl | pmid:9597121 |