Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Pedersen KE et al. | Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9152370 |
Takano T et al. | Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. | 1997 | J. Exp. Med. | pmid:9151906 |
Frieling T et al. | Leukotriene-evoked cyclic chloride secretion is mediated by enteric neuronal modulation in guinea-pig colon. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9151302 |
KuÅŸtimur S et al. | Effect of nordihydroguaretic acid and fluconazole on the LTC4/PGE2 ratio in the kidney of mice damaged by Candida albicans. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150373 |
Bozkurt S et al. | The cytoprotective effect of iloprost against carbon tetrachloride induced necrosis in rat liver. | 1997 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9144840 |
Nguyen T and Gupta S | Leukotriene C4 secretion from normal murine mast cells by a probenecid-sensitive and multidrug resistance-associated protein-independent mechanism. | 1997 | J. Immunol. | pmid:9144509 |
Carter BZ et al. | Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice. | 1997 | J. Biol. Chem. | pmid:9139674 |
Bureau MF et al. | 5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. | 1997 | Eur. J. Pharmacol. | pmid:9137918 |
el-Ahmady O et al. | Elevated concentrations of interleukins and leukotriene in response to Mycobacterium tuberculosis infection. | 1997 | Ann. Clin. Biochem. | pmid:9133249 |
Ishizuka Y et al. | Effect of 1,6-dihydro-2[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidineca rboxyli c acid on ethanol-induced microvascular injury in rats. | 1996 | Arzneimittelforschung | pmid:9125278 |
Hsieh KH | Evaluation of efficacy of traditional Chinese medicines in the treatment of childhood bronchial asthma: clinical trial, immunological tests and animal study. Taiwan Asthma Study Group. | 1996 | Pediatr Allergy Immunol | pmid:9116877 |
Sala A et al. | Pharmacological modulation of human platelet leukotriene C4-synthase. | 1997 | Biochem. Pharmacol. | pmid:9113110 |
Zeltsman D et al. | Pathophysiologic plasma levels of leukotriene C4 in relation to the hemodynamic dysfunction and mediator release of graded bacteremia. | 1997 | Shock | pmid:9110414 |
Madon J et al. | Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. | 1997 | FEBS Lett. | pmid:9109389 |
Gagari E et al. | Differential release of mast cell interleukin-6 via c-kit. | 1997 | Blood | pmid:9108382 |
Wang D et al. | An approach to the understanding of the nasal early-phase reaction induced by nasal allergen challenge. | 1997 | Allergy | pmid:9105520 |
Puder M and Soberman RJ | Glutathione conjugates recognize the Rossmann fold of glyceraldehyde-3-phosphate dehydrogenase. | 1997 | J. Biol. Chem. | pmid:9099752 |
Scoggan KA et al. | Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes. | 1997 | J. Biol. Chem. | pmid:9092565 |
de Paulis A et al. | Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs. | 1997 | Arthritis Rheum. | pmid:9082935 |
Sumizawa T et al. | Reversal of multidrug resistance-associated protein-mediated drug resistance by the pyridine analog PAK-104P. | 1997 | Mol. Pharmacol. | pmid:9058594 |