LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Neointima D058426 3 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Myocardial Ischemia D017202 11 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Reperfusion Injury D015427 65 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Uveitis D014605 14 associated lipids
Ulcer D014456 16 associated lipids
Stomach Ulcer D013276 75 associated lipids
Status Asthmaticus D013224 4 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Pedersen KE et al. Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. 1997 J. Pharmacol. Exp. Ther. pmid:9152370
Takano T et al. Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. 1997 J. Exp. Med. pmid:9151906
Frieling T et al. Leukotriene-evoked cyclic chloride secretion is mediated by enteric neuronal modulation in guinea-pig colon. 1997 Naunyn Schmiedebergs Arch. Pharmacol. pmid:9151302
KuÅŸtimur S et al. Effect of nordihydroguaretic acid and fluconazole on the LTC4/PGE2 ratio in the kidney of mice damaged by Candida albicans. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9150373
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Hsieh KH Evaluation of efficacy of traditional Chinese medicines in the treatment of childhood bronchial asthma: clinical trial, immunological tests and animal study. Taiwan Asthma Study Group. 1996 Pediatr Allergy Immunol pmid:9116877
Sala A et al. Pharmacological modulation of human platelet leukotriene C4-synthase. 1997 Biochem. Pharmacol. pmid:9113110
Zeltsman D et al. Pathophysiologic plasma levels of leukotriene C4 in relation to the hemodynamic dysfunction and mediator release of graded bacteremia. 1997 Shock pmid:9110414
Madon J et al. Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. 1997 FEBS Lett. pmid:9109389
Gagari E et al. Differential release of mast cell interleukin-6 via c-kit. 1997 Blood pmid:9108382
Wang D et al. An approach to the understanding of the nasal early-phase reaction induced by nasal allergen challenge. 1997 Allergy pmid:9105520
Puder M and Soberman RJ Glutathione conjugates recognize the Rossmann fold of glyceraldehyde-3-phosphate dehydrogenase. 1997 J. Biol. Chem. pmid:9099752
Scoggan KA et al. Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes. 1997 J. Biol. Chem. pmid:9092565
de Paulis A et al. Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs. 1997 Arthritis Rheum. pmid:9082935
Sumizawa T et al. Reversal of multidrug resistance-associated protein-mediated drug resistance by the pyridine analog PAK-104P. 1997 Mol. Pharmacol. pmid:9058594