LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Sanchez Mejia RO et al. Matrix-associated transforming growth factor-beta1 primes mouse bone marrow-derived mast cells for increased high-affinity Fc receptor for immunoglobulin E-dependent eicosanoid biosynthesis. 2000 Am. J. Respir. Cell Mol. Biol. pmid:10783127
Macfarlane AJ et al. Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. 2000 Am. J. Respir. Crit. Care Med. pmid:10806153
Sakamoto H et al. Involvement of phospholipid hydroperoxide glutathione peroxidase in the modulation of prostaglandin D2 synthesis. 2000 J. Biol. Chem. pmid:11010961
Kivity S et al. Eosinophil influx into the airways in patients with exercise-induced asthma. 2000 Respir Med pmid:11192956
Hamasaki Y et al. (9-[4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido [1,2-a] pyrimidin-4-one), AS-35, inhibits leukotriene synthesis. 2000 Int. J. Immunopharmacol. pmid:10785545
Bandeira-Melo C et al. Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. 2000 J. Immunol. pmid:10623853
Yakubu MA and Leffler CW Enhanced pial arteriolar sensitivity to bioactive agents following exposure to endothelin-1. 2000 Life Sci. pmid:10665982
Mitsunobu F et al. Enhanced peripheral leukocyte leukotriene production and bronchial hyperresponsiveness in asthmatics. 2000 Eur. Respir. J. pmid:11028668
Anderson MR and Blumer JL Prognostic markers in sepsis: the role of leukotrienes. 2000 Crit. Care Med. pmid:11098993
Malaviya R et al. Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). 2000 J. Pharmacol. Exp. Ther. pmid:11082424
Capper EA et al. Modulation of human monocyte activities by tranilast, SB 252218, a compound demonstrating efficacy in restenosis. 2000 J. Pharmacol. Exp. Ther. pmid:11082441
Díaz AM et al. In vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L. 2000 Biol. Pharm. Bull. pmid:11085357
Tran HS et al. The cardiovascular hemodynamics and leukotriene kinetics during prostacyclin and anti-prostacyclin antibody infusions in septic shock. 2000 Shock pmid:10847636
Heise CE et al. Characterization of the human cysteinyl leukotriene 2 receptor. 2000 J. Biol. Chem. pmid:10851239
Malaviya R and Abraham SN Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis. 2000 J. Leukoc. Biol. pmid:10857857
Gutmann H et al. P-glycoprotein- and mrp2-mediated octreotide transport in renal proximal tubule. 2000 Br. J. Pharmacol. pmid:10694230
Sundkvist E et al. Leukotriene C(4) (LTC(4)) does not share a cellular efflux mechanism with cGMP: characterisation of cGMP transport by uptake to inside-out vesicles from human erythrocytes. 2000 Biochim. Biophys. Acta pmid:10631301
Ding GY et al. Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles. 1999 Jul-Aug Anticancer Res. pmid:10652618
Nakasato H et al. Prevention of severe premenstrual asthma attacks by leukotriene receptor antagonist. 1999 J. Allergy Clin. Immunol. pmid:10482831
O'Connor BJ et al. Selective airway responsiveness in asthma. 1999 Trends Pharmacol. Sci. pmid:10101956
Akpek EA et al. A study of adenosine treatment in experimental acute spinal cord injury. Effect on arachidonic acid metabolites. 1999 Spine pmid:9926381
Niinuma K et al. Primary active transport of organic anions on bile canalicular membrane in humans. 1999 Am. J. Physiol. pmid:10330006
Lärfars G et al. Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. 1999 Blood pmid:9949184
Hamasaki Y et al. Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells. 1999 Planta Med. pmid:10232065
Lay JC et al. Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. 1999 Am. J. Respir. Cell Mol. Biol. pmid:10100994
Lankisch TO et al. High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. 1999 Eur. J. Cell Biol. pmid:10535305
Cordoba-Rodriguez R et al. Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393875
Takao A et al. Inhibitory effects of azelastine hydrochloride in alcohol-induced asthma. 1999 Ann. Allergy Asthma Immunol. pmid:10227338
Denizot Y et al. Are lipid mediators implicated in the production of pro- and anti-inflammatory cytokines during cardiopulmonary bypass graft with extracorporeal circulation? 1999 Cytokine pmid:10328869
Miura K et al. Extracellular signal-regulated kinases regulate leukotriene C4 generation, but not histamine release or IL-4 production from human basophils. 1999 J. Immunol. pmid:10201947
Mao Q et al. ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells. 1999 Biochim. Biophys. Acta pmid:10556489
Held HD et al. Characterization of airway and vascular responses in murine lungs. 1999 Br. J. Pharmacol. pmid:10205008
Rao AM et al. CDP-choline: neuroprotection in transient forebrain ischemia of gerbils. 1999 J. Neurosci. Res. pmid:10561698
Malaviya R and Uckun FM Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions. 1999 Biochem. Biophys. Res. Commun. pmid:10208864
Norman BH et al. Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146. 1999 Bioorg. Med. Chem. Lett. pmid:10612603
Desplat V et al. Incorporation and effect of arachidonic acid on the growth of human myeloma cell lines. 1999 Mediators Inflamm. pmid:10704149
Chen ZS et al. Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. 1999 Mol. Pharmacol. pmid:10570049
Nilsen A et al. Short-term exposure of rodents to diesel exhausts: usefulness for studies of genotoxic and immunotoxic effects. 1999 Chem. Biol. Interact. pmid:10227576
Constable AL et al. DMSO induction of the leukotriene LTC4 by Lewis rat Schwann cells. 1999 J. Neurol. Sci. pmid:10202977
Miadonna A et al. Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. 1999 Clin. Exp. Allergy pmid:10383595
Ko JK and Cho CH Co-regulation of mucosal nitric oxide and prostaglandin in gastric adaptive cytoprotection. 1999 Inflamm. Res. pmid:10522801
Van Aubel RA et al. Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells. 1999 Mol. Pharmacol. pmid:10496953
Hagmann W et al. Purification of the human apical conjugate export pump MRP2 reconstitution and functional characterization as substrate-stimulated ATPase. 1999 Eur. J. Biochem. pmid:10491184
Falcón-Pérez JM et al. Functional domain analysis of the yeast ABC transporter Ycf1p by site-directed mutagenesis. 1999 J. Biol. Chem. pmid:10438540
Campbell EM et al. Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. 1999 J. Immunol. pmid:10438957
Kawabe T et al. Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). 1999 FEBS Lett. pmid:10456333
Vellenga E et al. Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. 1999 Br. J. Pharmacol. pmid:10385244
Stride BD et al. Localization of a substrate specificity domain in the multidrug resistance protein. 1999 J. Biol. Chem. pmid:10428874
Ochensberger B et al. Regulation of cytokine expression and leukotriene formation in human basophils by growth factors, chemokines and chemotactic agonists. 1999 Eur. J. Immunol. pmid:9933081
Amann R et al. Eicosanoid release in the endotoxin-primed isolated perfused rat lung and its pharmacological modification. 1999 Inflamm. Res. pmid:10669114