| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Carcinoma, Small Cell | D018288 | 21 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fujii R et al. | Adenosine triphosphate-dependent transport of leukotriene C4 by membrane vesicles prepared from cisplatin-resistant human epidermoid carcinoma tumor cells. | 1994 | J. Natl. Cancer Inst. | pmid:7966417 |
| Leier I et al. | The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. | 1994 | J. Biol. Chem. | pmid:7961706 |
| Böhme M et al. | ATP-dependent export pumps and their inhibition by cyclosporins. | 1994 | Adv. Enzyme Regul. | pmid:7942282 |
| Black KL et al. | Enzymatic barrier protects brain capillaries from leukotriene C4. | 1994 | J. Neurosurg. | pmid:7931622 |
| Volland H et al. | Enzyme immunometric assay for leukotriene C4. | 1994 | J. Immunol. Methods | pmid:7930643 |
| Anwar AR et al. | Adhesion to fibronectin primes eosinophils via alpha 4 beta 1 (VLA-4). | 1994 | Immunology | pmid:7927493 |
| Matsumoto T et al. | Effects of diet on experimentally induced intestinal ulcers in rats: morphology and tissue leukotrienes. | 1994 | Gut | pmid:7926906 |
| Büchler M et al. | Functional reconstitution of ATP-dependent transporters from the solubilized hepatocyte canalicular membrane. | 1994 | Eur. J. Biochem. | pmid:7925347 |
| Leff AR | Inflammatory mediation of airway hyperresponsiveness by peripheral blood granulocytes. The case for the eosinophil. | 1994 | Chest | pmid:7924496 |
| Ducep JB et al. | Synthesis of 5- and 6-fluoro derivatives of 5,8,14-eicosatrienoic and 5,8,11,14-eicosatetraenoic acids. Effects of fluorinated arachidonic acids on leukotriene C4 production by macrophages. | 1994 | Bioorg. Med. Chem. | pmid:7922133 |
| Ohemeng KA et al. | Novel bishydroxamic acids as 5-lipoxygenase inhibitors. | 1994 | Bioorg. Med. Chem. | pmid:7922131 |
| Kapuściński A | Leukotriene C4 in the rat brain after resuscitation from clinical death. | 1994 | Folia Neuropathol | pmid:7922113 |
| Jedlitschky G et al. | ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. | 1994 | Cancer Res. | pmid:7915193 |
| Thioudellet C et al. | Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. | 1994 | Eur. J. Biochem. | pmid:7913033 |
| Ohtsuki T et al. | Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain. | 1995 | Am. J. Physiol. | pmid:7900879 |
| Kawana S and Nishiyama S | Pustular psoriasis and aseptic purulent arthritis: possible role of leukotrienes B4 and C4 in a flare of synovitis. | 1995 | Dermatology (Basel) | pmid:7894093 |
| Scadding GK et al. | Effect of short-term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge. | 1994 | Br J Clin Pharmacol | pmid:7893587 |
| Mita H and Shida T | Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes. | 1995 | Arzneimittelforschung | pmid:7893266 |
| Tsai JJ et al. | Relationship between nasal resistance and airway hyperreactivity following nasal provocation with Dermatophagoides pteronyssinus in allergic rhinitis. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888791 |
| Wang D et al. | Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888790 |
| Kawashima T et al. | [Inhibitory effect of AS-35. a novel antiallergic drug, on chemical mediator release from human eosinophils]. | 1994 | Arerugi | pmid:7887808 |
| Restrick LJ et al. | Reduction in leukotriene B4 generation by bronchoalveolar lavage cells in asthma. | 1995 | Thorax | pmid:7886653 |
| Yamaya M et al. | Epithelial modulation of leukotriene-C4-induced human tracheal smooth muscle contraction. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7881688 |
| Pintos-Morell G et al. | Altered leukotriene generation in leukocytes from cystinotic children. | 1994 | Pediatr. Res. | pmid:7877883 |
| Ganbo T et al. | Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. | 1995 | Ann. Otol. Rhinol. Laryngol. | pmid:7872607 |
| Enderle GJ et al. | Different pathomechanisms of altered biliary leukotriene C4 elimination in isolated perfused rat livers. | 1995 | Biochem. Pharmacol. | pmid:7857316 |
| Petric R and Ford-Hutchinson AW | Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. | 1994 | Kidney Int. | pmid:7853790 |
| Schuil PJ et al. | Histamine and leukotriene C4 effects on in vitro ciliary beat frequency of human upper respiratory cilia. | 1994 | Eur Arch Otorhinolaryngol | pmid:7848641 |
| Liu L et al. | Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum. | 1994 | Arzneimittelforschung | pmid:7848335 |
| HasanoÄŸlu E et al. | The role of prostanoids in the complications of extracorporeal shock wave lithotripsy (ESWL) in children. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846111 |
| Hubbard NE and Erickson KL | Role of 5'-lipoxygenase metabolites in the activation of peritoneal macrophages for tumoricidal function. | 1995 | Cell. Immunol. | pmid:7842477 |
| Kurosawa M et al. | Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs. | 1994 | Clin. Exp. Allergy | pmid:7842366 |
| Brady HR et al. | Lipoxygenase product formation and cell adhesion during neutrophil-glomerular endothelial cell interaction. | 1995 | Am. J. Physiol. | pmid:7840235 |
| Petric R et al. | Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. | 1995 | Biochim. Biophys. Acta | pmid:7827126 |
| Wang D et al. | Concentrations of chemical mediators in nasal secretions of patients with hay fever during natural allergen exposure. | 1994 | Acta Otolaryngol. | pmid:7825440 |
| Willburger RE and Wittenberg RH | Prostaglandin release from lumbar disc and facet joint tissue. | 1994 | Spine | pmid:7825047 |
| Currie S et al. | Phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in MCII mast cells mediated by high-affinity Fc receptor for IgE. | 1994 | Biochem. J. | pmid:7818499 |
| Müller M et al. | Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7809167 |
| Goulet JL et al. | Altered inflammatory responses in leukotriene-deficient mice. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7809134 |
| Shimizu T et al. | Inhibitory effects of theophylline, terbutaline, and hydrocortisone on leukotriene B4 and C4 generation by human leukocytes in vitro. | 1994 | Pediatr. Pulmonol. | pmid:7800427 |
| Gorenne I et al. | Antagonism of leukotriene responses in human airways by BAY x7195. | 1995 | Eur. J. Pharmacol. | pmid:7796856 |
| Ramondt J et al. | Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. | 1995 | Prostaglandins | pmid:7792392 |
| Ju HR et al. | Systemic release of mucosal mast-cell protease in primed brown Norway rats after feeding with beta-lactoglobulin. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7787291 |
| Gorenne I et al. | Effects of beta 2-adrenoceptor agonists on anti-IgE-induced contraction and smooth muscle reactivity in human airways. | 1995 | Br. J. Pharmacol. | pmid:7780648 |
| Kimura Y et al. | Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. | 1995 | J Ethnopharmacol | pmid:7776662 |
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| RodrÃguez-Ortigosa CM et al. | Taurocholate-stimulated leukotriene C4 biosynthesis and leukotriene C4-stimulated choleresis in isolated rat liver. | 1995 | Gastroenterology | pmid:7768385 |
| Porreca E et al. | Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. | 1995 | Atherosclerosis | pmid:7755646 |