LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xiang Y et al. | Anti-inflammatory effect of acetylpuerarin on eicosanoid signaling pathway in primary rat astrocytes. | 2014 | J. Mol. Neurosci. | pmid:24026619 |
| Eaton A et al. | Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression. | 2012 | J. Mol. Med. | pmid:22527886 |
| Zhou M et al. | In vivo intranasal anti-CD23 treatment inhibits allergic responses in a murine model of allergic rhinitis. | 2013 | J. Mol. Histol. | pmid:23377922 |
| Becher UM et al. | Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury. | 2011 | J. Mol. Cell. Cardiol. | pmid:21112334 |
| Seres I et al. | The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome. | 2006 | J. Membr. Biol. | pmid:17546512 |
| Seno K et al. | Pyrrolidine inhibitors of human cytosolic phospholipase A(2). | 2000 | J. Med. Chem. | pmid:10737736 |
| Mayatepek E et al. | Synthesis and metabolism of leukotrienes in gamma-glutamyl transpeptidase deficiency. | 2004 | J. Lipid Res. | pmid:14754911 |
| Dichlberger A et al. | Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells. | 2014 | J. Lipid Res. | pmid:25114172 |
| Sjölinder M et al. | Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. | 1999 | J. Lipid Res. | pmid:10064732 |
| Lukic A et al. | Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4. | 2016 | J. Lipid Res. | pmid:27436590 |
| Gibbs BF et al. | Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization. | 2002 | J. Leukoc. Biol. | pmid:12149431 |
| Oliveira SH et al. | Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. | 2002 | J. Leukoc. Biol. | pmid:12050188 |
| Inoue T et al. | Nitric Oxide positively regulates Ag (I)-induced Ca(2+) influx and mast cell activation: role of a Nitric Oxide Synthase-independent pathway. | 2009 | J. Leukoc. Biol. | pmid:19706839 |
| Raible DG | Erythrocytes increase leukotriene C4 release from human eosinophils: characterization and examination of possible mechanisms. | 1994 | J. Leukoc. Biol. | pmid:8027672 |
| Gibbs BF and Grabbe J | Inhibitors of PI 3-kinase and MEK kinase differentially affect mediator secretion from immunologically activated human basophils. | 1999 | J. Leukoc. Biol. | pmid:10380914 |
| Blanchet MR et al. | Modulation of eosinophil activation in vitro by a nicotinic receptor agonist. | 2007 | J. Leukoc. Biol. | pmid:17289799 |
| Hom JT et al. | The amyloidogenic peptide human amylin augments the inflammatory activities of eosinophils. | 1995 | J. Leukoc. Biol. | pmid:7595053 |
| Malaviya R and Abraham SN | Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis. | 2000 | J. Leukoc. Biol. | pmid:10857857 |
| Tsuruta R et al. | Soluble vascular cell adhesion molecule (VCAM)-Fc fusion protein induces leukotriene C4 secretion in platelet-activating factor-stimulated eosinophils. | 1999 | J. Leukoc. Biol. | pmid:9886248 |
| Rossi A et al. | Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}. | 2005 | J. Leukoc. Biol. | pmid:16046553 |
| Kobayashi H et al. | Urinary trypsin inhibitor reduces the release of histamine from rat peritoneal mast cells. | 1998 | J. Lab. Clin. Med. | pmid:9579392 |
| Horikawa T et al. | Melanocyte mitogens induce both melanocyte chemokinesis and chemotaxis. | 1995 | J. Invest. Dermatol. | pmid:7530272 |
| Cederholm T et al. | Impaired leukotriene C4 generation in granulocytes from protein-energy malnourished chronically ill elderly. | 2000 | J. Intern. Med. | pmid:10886494 |
| Sichletidis L et al. | Comparative efficacy of salbutamol and salmeterol in exercise-induced asthma. | 1993 Mar-Apr | J. Int. Med. Res. | pmid:8243793 |
| Mayatepek E et al. | Acute metabolic crisis with extreme deficiency of glutathione in combination with decreased levels of leukotriene C4 in a patient with glutathione synthetase deficiency. | 2004 | J. Inherit. Metab. Dis. | pmid:15243994 |
| Mayatepek E et al. | Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism. | 2000 | J. Inherit. Metab. Dis. | pmid:10896305 |
| Mayatepek E et al. | LTB4 and LTC4 are absent in the cerebrospinal fluid of human immunodeficiency virus type 1-seropositive persons with toxoplasmic encephalitis: evidence for inhibition of 5-lipoxygenase by Toxoplasma gondii. | 1999 | J. Infect. Dis. | pmid:9952384 |
| Li GQ et al. | Effects of cyclooxygenase-1 and -2 gene disruption on Helicobacter pylori-induced gastric inflammation. | 2006 | J. Infect. Dis. | pmid:16518767 |
| Sedgwick JB et al. | Effect of isolation protocol on eosinophil function: Percoll gradients versus immunomagnetic beads. | 1996 | J. Immunol. Methods | pmid:8914593 |
| Laviolette M et al. | Comparison of two modified techniques for purifying blood eosinophils. | 1993 | J. Immunol. Methods | pmid:8228275 |
| Volland H et al. | Enzyme immunometric assay for leukotriene C4. | 1994 | J. Immunol. Methods | pmid:7930643 |
| Tsang S et al. | Simplified purification of human basophils. | 2000 | J. Immunol. Methods | pmid:10648851 |
| Muñoz NM et al. | Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils. | 2006 | J. Immunol. | pmid:16785555 |
| Malaviya R and Uckun FM | Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells. | 2002 | J. Immunol. | pmid:11751988 |
| Miura K et al. | Localizing a control region in the pathway to leukotriene C(4) secretion following stimulation of human basophils with anti-IgE antibody. | 2001 | J. Immunol. | pmid:11739523 |
| Kita H et al. | Eosinophil major basic protein induces degranulation and IL-8 production by human eosinophils. | 1995 | J. Immunol. | pmid:7722326 |
| Thomas LL et al. | Immobilized lactoferrin is a stimulus for eosinophil activation. | 2002 | J. Immunol. | pmid:12097406 |
| Chibana K et al. | Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin. | 2003 | J. Immunol. | pmid:12682264 |
| Egger D et al. | IL-4 renders mast cells functionally responsive to endothelin-1. | 1995 | J. Immunol. | pmid:7530742 |
| Kita H et al. | Does IgE bind to and activate eosinophils from patients with allergy? | 1999 | J. Immunol. | pmid:10352312 |
| Suzuki Y et al. | Silver activates calcium signals in rat basophilic leukemia-2H3 mast cells by a mechanism that differs from the Fc epsilon RI-activated response. | 2002 | J. Immunol. | pmid:12244196 |
| Bandeira-Melo C et al. | Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. | 2000 | J. Immunol. | pmid:10623853 |
| Miyamasu M et al. | Chemotactic agonists induce cytokine generation in eosinophils. | 1995 | J. Immunol. | pmid:7529800 |
| Cummings HE et al. | Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. | 2013 | J. Immunol. | pmid:24244016 |
| Moore BB et al. | GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism. | 2000 | J. Immunol. | pmid:11034414 |
| Okayama Y et al. | A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI. | 2001 | J. Immunol. | pmid:11254731 |
| Dartt DA et al. | Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. | 2011 | J. Immunol. | pmid:21357260 |
| Miura K and MacGlashan DW | Dual phase priming by IL-3 for leukotriene C4 generation in human basophils: difference in characteristics between acute and late priming effects. | 2000 | J. Immunol. | pmid:10706691 |
| Douglas IS et al. | CD4+ T cell and eosinophil adhesion is mediated by specific ICAM-3 ligation and results in eosinophil activation. | 2000 | J. Immunol. | pmid:10706734 |
| Duffy SM et al. | Resting and activation-dependent ion channels in human mast cells. | 2001 | J. Immunol. | pmid:11591748 |