LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Edema D004487 152 associated lipids
Inflammation D007249 119 associated lipids
Glioma D005910 112 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Brain Ischemia D002545 89 associated lipids
Atherosclerosis D050197 85 associated lipids
Stomach Ulcer D013276 75 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Colitis D003092 69 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Reperfusion Injury D015427 65 associated lipids
Asthma D001249 52 associated lipids
Osteosarcoma D012516 50 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Arthritis D001168 41 associated lipids
Hypotension D007022 41 associated lipids
Peritonitis D010538 38 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Glomerulonephritis D005921 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Burns D002056 34 associated lipids
Drug Eruptions D003875 30 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Angina Pectoris D000787 27 associated lipids
Gastritis D005756 27 associated lipids
Nasal Polyps D009298 26 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Cough D003371 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Ulcer D014456 16 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Uveitis D014605 14 associated lipids
Airway Obstruction D000402 13 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Acute-Phase Reaction D000210 12 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Diven WF et al. Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. 1998 Ann. Otol. Rhinol. Laryngol. pmid:9525240
Ganbo T et al. Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. 1995 Ann. Otol. Rhinol. Laryngol. pmid:7872607
Mayatepek E et al. A patient with neurological symptoms and abnormal leukotriene metabolism: a new defect in leukotriene biosynthesis. 2005 Ann. Neurol. pmid:16315285
Laviolette M et al. Effects of inhaled steroids on blood eosinophils in moderate asthma. 1994 Ann. N. Y. Acad. Sci. pmid:8031001
Maclouf J et al. Leukotriene C4 formation by transcellular biosynthesis. 1994 Ann. N. Y. Acad. Sci. pmid:8017763
el-Ahmady O et al. Elevated concentrations of interleukins and leukotriene in response to Mycobacterium tuberculosis infection. 1997 Ann. Clin. Biochem. pmid:9133249
Gentile DA et al. Elevations of local leukotriene C4 levels during viral upper respiratory tract infections. 2003 Ann. Allergy Asthma Immunol. pmid:14533659
Hamasaki Y et al. Inhibition of leukotriene synthesis by azelastine. 1996 Ann. Allergy Asthma Immunol. pmid:8630722
Takao A et al. Inhibitory effects of azelastine hydrochloride in alcohol-induced asthma. 1999 Ann. Allergy Asthma Immunol. pmid:10227338
Moneret-Vautrin DA et al. Human basophil activation measured by CD63 expression and LTC4 release in IgE-mediated food allergy. 1999 Ann. Allergy Asthma Immunol. pmid:9988204
Bölke E et al. Changes of gut barrier function during anesthesia and cardiac surgery. 2001 Angiology pmid:11515987
Wiklund CU et al. Interactions of volatile anesthetics with cholinergic, tachykinin, and leukotriene mechanisms in isolated Guinea pig bronchial smooth muscle. 2002 Anesth. Analg. pmid:12456432
Tsikas D et al. Catalytic hydrogenation of leukotriene B4 enhances sensitivity and specificity of gas chromatography-tandem mass spectrometry techniques and enables simultaneous analysis with cysteinyl leukotrienes in biological fluids. 1996 Anal. Biochem. pmid:8619486
Wickham S et al. Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. 2011 Anal. Biochem. pmid:21447318
Tabas LB and Dantzig AH A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles. 2002 Anal. Biochem. pmid:12413474
Westcott JY et al. Inactivation of leukotriene C4 in the airways and subsequent urinary leukotriene E4 excretion in normal and asthmatic subjects. 1993 Am. Rev. Respir. Dis. pmid:7694531
Lester GD and Rice BL Effects of leukotriene C4 on the bioelectric properties and ion transport of equine tracheal epithelium. 2012 Am. J. Vet. Res. pmid:23176432
Myers SI and Hernandez R Leukotriene C4 regulation of splanchnic blood flow during ischemia. 1994 Am. J. Surg. pmid:8209929
Suzuki R and Freed AN Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. 2002 Am. J. Respir. Crit. Care Med. pmid:11779726
Macfarlane AJ et al. Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. 2000 Am. J. Respir. Crit. Care Med. pmid:10806153
Meltzer SS et al. Inhibition of exercise-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor. 1996 Am. J. Respir. Crit. Care Med. pmid:8630575
Burghardt JS et al. Lipid mediators in oxygen-induced airway remodeling and hyperresponsiveness in newborn rats. 1996 Am. J. Respir. Crit. Care Med. pmid:8887572
Chen CR et al. Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids. 1994 Am. J. Respir. Crit. Care Med. pmid:8111595
Sano A et al. Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. 1999 Am. J. Respir. Crit. Care Med. pmid:10351938
Hasday JD et al. Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics. 2000 Am. J. Respir. Crit. Care Med. pmid:10764316
Yamaya M et al. Epithelial modulation of leukotriene-C4-induced human tracheal smooth muscle contraction. 1995 Am. J. Respir. Crit. Care Med. pmid:7881688
Peters-Golden M Cell biology of the 5-lipoxygenase pathway. 1998 Am. J. Respir. Crit. Care Med. pmid:9647604
Vargaftig BB and Singer M Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. 2003 Am. J. Respir. Cell Mol. Biol. pmid:12654629
Perng DW et al. Leukotriene C4 induces TGF-beta1 production in airway epithelium via p38 kinase pathway. 2006 Am. J. Respir. Cell Mol. Biol. pmid:16179583
Sanchez Mejia RO et al. Matrix-associated transforming growth factor-beta1 primes mouse bone marrow-derived mast cells for increased high-affinity Fc receptor for immunoglobulin E-dependent eicosanoid biosynthesis. 2000 Am. J. Respir. Cell Mol. Biol. pmid:10783127
Cai Y et al. Bronchial mast cells are the dominating LTC4S-expressing cells in aspirin-tolerant asthma. 2003 Am. J. Respir. Cell Mol. Biol. pmid:12816731
Hamasaki Y et al. Inhibition by dexamethasone of retinoic acid-induced enhancement of leukotriene C4 synthesis in rat basophilic leukemia-1 cells. 1994 Am. J. Respir. Cell Mol. Biol. pmid:8018338
Lay JC et al. Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. 1999 Am. J. Respir. Cell Mol. Biol. pmid:10100994
Vieira-de-Abreu A et al. Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene Câ‚„-synthesizing lipid bodies. 2011 Am. J. Respir. Cell Mol. Biol. pmid:20539011
Dent G et al. Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. 1998 Am. J. Respir. Cell Mol. Biol. pmid:9448055
Nagata M et al. Granulocyte macrophage colony-stimulating factor augments ICAM-1 and VCAM-1 activation of eosinophil function. 1998 Am. J. Respir. Cell Mol. Biol. pmid:9651192
Funayama T et al. Role of Leukotriene-degrading enzymes in pulmonary response to antigen infusion in sensitized guinea pigs in vivo. 1996 Am. J. Respir. Cell Mol. Biol. pmid:8703483
Vieira-de-Abreu A et al. Allergic challenge-elicited lipid bodies compartmentalize in vivo leukotriene C4 synthesis within eosinophils. 2005 Am. J. Respir. Cell Mol. Biol. pmid:15947420
Downey P et al. Renal concentrating defect in mice lacking group IV cytosolic phospholipase A(2). 2001 Am. J. Physiol. Renal Physiol. pmid:11249852
Miller DS et al. Xenobiotic efflux pumps in isolated fish brain capillaries. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11742838
Reichel V et al. Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus. 2008 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:18650317
Sano A et al. Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA(2). 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11557588
Serio KJ et al. TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16980379
Vargaftig BB and Singer M Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12794006
Kingham PJ et al. Adhesion-dependent interactions between eosinophils and cholinergic nerves. 2002 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12003778
Sawatzky DA et al. Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation. 2002 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12003784
Oliveira SH et al. SCF-induced airway hyperreactivity is dependent on leukotriene production. 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11350804
Muñoz NM et al. Augmentation of LTC(4) synthesis in human eosinophils caused by CD3-stimulated Th2-like cells in vitro. 2000 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:10835322
Nagase T et al. A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12505870
Vargaftig BB and Singer M Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12388339
Liu P et al. Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12531730
Liu S et al. Neuroimmune interactions in guinea pig stomach and small intestine. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12388180
Oleschuk CJ et al. Substitution of Trp1242 of TM17 alters substrate specificity of human multidrug resistance protein 3. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12388190
Keitel V et al. A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2). 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12388192
Lee TK et al. N-glycosylation controls functional activity of Oatp1, an organic anion transporter. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12702494
Hattori Y et al. Gastric mucosal protection against ethanol by EP2 and EP4 signaling through the inhibition of leukotriene C4 production. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17947453
Hamann KJ et al. Effects of activated eosinophils cultured from human umbilical cord blood on guinea pig trachealis. 1993 Am. J. Physiol. pmid:8214090
Niinuma K et al. Primary active transport of organic anions on bile canalicular membrane in humans. 1999 Am. J. Physiol. pmid:10330006
Huber W et al. Leukotriene B4 and C4 production in isolated rat gastric mucosal cells. 1993 Am. J. Physiol. pmid:8279553
Miller DS et al. Excretory transport of xenobiotics by dogfish shark rectal gland tubules. 1998 Am. J. Physiol. pmid:9728065
Grønbech JE and Lacy ER Role of gastric blood flow in impaired defense and repair of aged rat stomachs. 1995 Am. J. Physiol. pmid:7491966
Brady HR et al. Lipoxygenase product formation and cell adhesion during neutrophil-glomerular endothelial cell interaction. 1995 Am. J. Physiol. pmid:7840235
Carvalho-Tavares J et al. Assessment of the mechanism of juxtacrine activation and adhesion of leukocytes in liver microcirculation. 1999 Am. J. Physiol. pmid:10198324
Fiorucci S et al. Effect of NSAIDs on pepsinogen secretion and calcium mobilization in isolated chief cells. 1995 Am. J. Physiol. pmid:7611418
Muñoz NM et al. Augmentation of eosinophil degranulation and LTC(4) secretion by integrin-mediated endothelial cell adhesion. 1999 Am. J. Physiol. pmid:10516222
Ohtsuki T et al. Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain. 1995 Am. J. Physiol. pmid:7900879
Sato E et al. Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. 1998 Am. J. Physiol. pmid:9609736
Abela A and Daniel EE Neural and myogenic effects of leukotrienes C4, D4, and E4 on canine bronchial smooth muscle. 1994 Am. J. Physiol. pmid:8179018
Ganbo T et al. Leukotriene C4 inhibits ciliary activity in the presence of gamma-glutamyl transpeptidase. 1996 Am. J. Physiol. pmid:8770059
Muñoz NM et al. Eosinophil VLA-4 binding to fibronectin augments bronchial narrowing through 5-lipoxygenase activation. 1996 Am. J. Physiol. pmid:8928818
Gronert K et al. Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. 2001 Am. J. Pathol. pmid:11141472
John AE et al. Temporal production of CCL28 corresponds to eosinophil accumulation and airway hyperreactivity in allergic airway inflammation. 2005 Am. J. Pathol. pmid:15681819
Romero R et al. Increased amniotic fluid leukotriene C4 concentration in term human parturition. 1988 Am. J. Obstet. Gynecol. pmid:3421265
Dellon ES et al. Diagnostic utility of major basic protein, eotaxin-3, and leukotriene enzyme staining in eosinophilic esophagitis. 2012 Am. J. Gastroenterol. pmid:22777338
Sternfeld M et al. The role of acupuncture in asthma: changes in airways dynamics and LTC4 induced LAI. 1989 Am. J. Chin. Med. pmid:2633615
Song HH et al. Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells. 2012 Am. J. Chin. Med. pmid:22928836
Takase B et al. Effects of bepridil on silent myocardial ischemia and eicosanoid metabolism in chronic stable angina pectoris after healing of myocardial infarction. 1994 Am. J. Cardiol. pmid:8198031
Malaviya R and Uckun FM Leflunomide metabolite analogue alpha-cyano-beta-hydroxy-beta-methyl-N-[3-(trifluoromethyl)phenyl]propenamide inhibits IgE/FcepsilonRI receptor-mediated mast cell leukotriene release and allergic asthma in mice. 2001 Sep-Oct Am J Ther pmid:11550070
Kramer MF et al. Factors contributing to nasal allergic late phase eosinophilia. 2006 May-Jun Am J Otolaryngol pmid:16647984
Klapan I et al. Arachidonic acid metabolites and sinonasal polyposis. I. Possible prognostic value. 1995 Nov-Dec Am J Otolaryngol pmid:8572256
Jordan TR et al. An approach of immunoneurological aspects in nasal allergic late phase. 2005 Sep-Oct Allergy Asthma Proc pmid:16450573
Horak F et al. Effect of continuous allergen challenge on clinical symptoms and mediator release in dust-mite-allergic patients. 1998 Allergy pmid:9491231
Wang D et al. An approach to the understanding of the nasal early-phase reaction induced by nasal allergen challenge. 1997 Allergy pmid:9105520
Piette V et al. Sinus CT scans and mediator release in nasal secretions after nasal challenge with cypress pollens. 2004 Allergy pmid:15230820
Chavis C et al. Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity. 1997 Allergy pmid:9201374
Crampette L et al. Inhibition of mediator and cytokine release from dispersed nasal polyp cells by terfenadine. 1996 Allergy pmid:8836342
Zuberbier T et al. Histamine releasability of basophils and skin mast cells in chronic urticaria. 1996 Allergy pmid:8721524
Gurzeler U et al. In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8. 2013 Allergy pmid:23590216
Wang DY et al. The upper and lower airway responses to nasal challenge with house-dust mite Blomia tropicalis. 2003 Allergy pmid:12580812
Kupczyk M et al. Lipoxin A4 generation is decreased in aspirin-sensitive patients in lysine-aspirin nasal challenge in vivo model. 2009 Allergy pmid:19385948
Gulliksson M et al. Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells. 2006 Allergy pmid:17073880
Takafuji S et al. Release of granule proteins from human eosinophils stimulated with mast-cell mediators. 1998 Allergy pmid:9821474
Kowalski ML et al. Inhibition of nasal polyp mast cell and eosinophil activation by desloratadine. 2005 Allergy pmid:15575935
Schauer U et al. Blood eosinophils, eosinophil-derived proteins, and leukotriene C4 generation in relation to bronchial hyperreactivity in children with atopic dermatitis. 1995 Allergy pmid:7604934
Kalayci O et al. ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. 2006 Allergy pmid:16364163
Taskila K et al. Histamine and LTC4 in stinging nettle-induced urticaria. 2000 Allergy pmid:10921474
Karaman O et al. The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis. 2001 Mar-Apr Allergol Immunopathol (Madr) pmid:11420028
Pereira-Vega A et al. Premenstrual asthma and leukotriene variations in the menstrual cycle. 2012 Nov-Dec Allergol Immunopathol (Madr) pmid:22115570
Sabbah A et al. [Allergy to mosquitoes and use of new immunobiological parameters]. 1997 Allerg Immunol (Paris) pmid:9254117
Sainte-Laudy J et al. [Demonstration of sulfite-group-specific IgE in patients with intolerance to preservatives]. 1994 Allerg Immunol (Paris) pmid:7518236