Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sainte-Laudy J et al. | [Bioclinical interest in the assay of leukotrienes in four cases of sensitization to trophallergens]. | 1997 | Allerg Immunol (Paris) | pmid:9254120 |
Sabbah A et al. | [Anaphylactic or anaphylactoid reactions to paracetamol. Report of 3 cases]. | 1997 | Allerg Immunol (Paris) | pmid:9221011 |
Sainte-Laudy J et al. | [Importance of the leukotriene C4 liberation test for the diagnosis of drug allergy (preliminary results)]. | 1996 | Allerg Immunol (Paris) | pmid:8703308 |
Sainte-Laudy J et al. | [Demonstration of sulfite-group-specific IgE in patients with intolerance to preservatives]. | 1994 | Allerg Immunol (Paris) | pmid:7518236 |
Collin N et al. | [Search for a threshold to distinguish between locoregional and systemic reactions using the histamine liberation value and the LTC4 level]. | 1999 | Allerg Immunol (Paris) | pmid:10070593 |
Florio G et al. | The immunoglobulin superantigen-binding site of HIV-1 gp120 activates human basophils. | 2000 | AIDS | pmid:10853974 |
Marquardt DL et al. | Mast cell desensitization to IgE fails to induce a parallel adenosine receptor desensitization. | 1993 | Agents Actions | pmid:8147265 |
Sirois MG et al. | Platelet activating factor modulates peptidoleukotriene effects on the permeability of bovine aortic endothelial cell to albumin. | 1993 | Agents Actions | pmid:8273559 |
Rainsford KD | Leukotrienes in the pathogenesis of NSAID-induced gastric and intestinal mucosal damage. | 1993 | Agents Actions | pmid:8273575 |
Butenko IG et al. | Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis georgy roots. | 1993 | Agents Actions | pmid:8273583 |
Ramachers U et al. | Direct effects of second-generation H1-receptor antagonists on the activation of human basophils. | 1994 | Agents Actions | pmid:7526656 |
Amon U et al. | Control function of protein kinase C isozymes on leukotriene generation from human basophils? | 1994 | Agents Actions | pmid:7976816 |
Lam BK et al. | Expression cloning of human LTC4 synthase. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732869 |
Busse WW and Sedgwick JB | Eosinophil eicosanoid relations in allergic inflammation of the airways. | 1994 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7771338 |
Gardiner PJ et al. | Leukotriene receptors and their selective antagonists. | 1994 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7771349 |
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Brady HR et al. | Transcellular pathways and cell adhesion as potential contributors to leukotriene and lipoxin biosynthesis in acute glomerulonephritis. | 1997 | Adv. Exp. Med. Biol. | pmid:9547614 |
Herman CA et al. | Synthesis and action of eicosanoids in warm and cold-acclimated amphibians. | 1997 | Adv. Exp. Med. Biol. | pmid:9561172 |
Sporn PH et al. | Keratinocyte growth factor increases LTC4 synthesis and expression of flap in cultured rat alveolar type II cells. | 1997 | Adv. Exp. Med. Biol. | pmid:9561179 |
Bäck M et al. | The contraction of the human pulmonary artery by LTC4 is resistant to cysLT1 antagonists and counteracted by prostacyclin release. | 2002 | Adv. Exp. Med. Biol. | pmid:12664603 |
Kalayci O et al. | LTC4 production by eosinophils in asthmatic subjects with alternative forms of ALOX-5 core promoter. | 2003 | Adv. Exp. Med. Biol. | pmid:12751728 |
Hsueh W et al. | Injurious and protective mechanisms in the gut. Interaction of PAF, phospholipase A2, eicosanoids, and nitric oxide synthase. | 1997 | Adv. Exp. Med. Biol. | pmid:9321977 |
Lieberman MW et al. | Gamma-glutamyl leukotrienase cleavage of leukotriene C4. | 1999 | Adv. Exp. Med. Biol. | pmid:10667345 |
Schweitzer P et al. | Cannabinoid modulation of neuronal activity in adult rat hippocampus. | 1999 | Adv. Exp. Med. Biol. | pmid:10667381 |
Herman CA and Luczy-Bachman G | Eicosanoids in the brain of warm- and cold-acclimated bullfrogs. | 1999 | Adv. Exp. Med. Biol. | pmid:10667397 |
Keppler D et al. | The function of the multidrug resistance proteins (MRP and cMRP) in drug conjugate transport and hepatobiliary excretion. | 1996 | Adv. Enzyme Regul. | pmid:8869738 |
Böhme M et al. | ATP-dependent export pumps and their inhibition by cyclosporins. | 1994 | Adv. Enzyme Regul. | pmid:7942282 |
Keppler D et al. | The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes. | 1997 | Adv. Enzyme Regul. | pmid:9381978 |
Bäck M et al. | Modulation of vascular tone and reactivity by nitric oxide in porcine pulmonary arteries and veins. | 2002 | Acta Physiol. Scand. | pmid:11851592 |
Jonsson EW | Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. | 1998 | Acta Physiol Scand Suppl | pmid:9597121 |
Deng YM et al. | Coincidental increase of leukotriene B4 between cerebral cortex and lung tissue of sensitized rats. | 2003 | Acta Pharmacol. Sin. | pmid:14531949 |
Wang D et al. | Concentrations of chemical mediators in nasal secretions of patients with hay fever during natural allergen exposure. | 1994 | Acta Otolaryngol. | pmid:7825440 |
Neu IS et al. | Leukotrienes in patients with clinically active multiple sclerosis. | 2002 | Acta Neurol. Scand. | pmid:11903112 |
Nagashima T et al. | The effect of leukotriene C4 on the permeability of brain capillary endothelial cell monolayer. | 1994 | Acta Neurochir Suppl (Wien) | pmid:7976646 |
Mifune T et al. | Chemical mediator and cellular reaction in the bronchoalveolar lavage fluid of patients with steroid-dependent intractable asthma (SDIA). | 1993 | Acta Med. Okayama | pmid:7505996 |
Nuutinen P et al. | Histamine, but not leukotriene C4, is an essential mediator in cold urticaria wheals. | 2007 | Acta Derm. Venereol. | pmid:17225008 |
Takala RS et al. | Pulmonary inflammatory mediators after sevoflurane and thiopentone anaesthesia in pigs. | 2004 | Acta Anaesthesiol Scand | pmid:14674972 |
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