Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Serio KJ et al. | TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16980379 |
Kowalski ML | Aspirin-sensitive rhinosinusitis and asthma. | 2007 | Clin Allergy Immunol | pmid:17153012 |
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Nuutinen P et al. | Histamine, but not leukotriene C4, is an essential mediator in cold urticaria wheals. | 2007 | Acta Derm. Venereol. | pmid:17225008 |
Yoshisue H et al. | Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts. | 2007 | J. Allergy Clin. Immunol. | pmid:17208594 |
Lee KS et al. | Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. | 2007 | J. Allergy Clin. Immunol. | pmid:17208595 |
Yang SL and Lou YJ | Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats. | 2007 | Biochem. Pharmacol. | pmid:17194456 |
Ebihara S et al. | A simple preparation method for mouse eosinophils and their responses to anti-allergic drugs. | 2007 | Inflamm. Res. | pmid:17406808 |
Kopp MV et al. | Omalizumab (Xolair) in children with seasonal allergic rhinitis: leukotriene release as a potential in vitro parameter to monitor therapeutic effects. | 2007 | Pediatr Allergy Immunol | pmid:17680911 |
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Zhang XC et al. | Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17483291 |
Chang WC et al. | All-or-none activation of CRAC channels by agonist elicits graded responses in populations of mast cells. | 2007 | J. Immunol. | pmid:17911611 |
Blanchet MR et al. | Modulation of eosinophil activation in vitro by a nicotinic receptor agonist. | 2007 | J. Leukoc. Biol. | pmid:17289799 |
Yang SL et al. | Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats. | 2007 | J. Surg. Res. | pmid:17397868 |
Yang JJ et al. | Multidrug resistance protein 1 (MRP1) in rabbit conjunctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection. | 2007 | Pharm. Res. | pmid:17404811 |
Mortaz E et al. | Stimulation of cysteinyl leukotriene production in mast cells by heat shock and acetylsalicylic acid. | 2007 | Eur. J. Pharmacol. | pmid:17306251 |
Zhang L et al. | Mechanistic study on the intestinal absorption and disposition of baicalein. | 2007 | Eur J Pharm Sci | pmid:17507208 |
Létourneau IJ et al. | Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function. | 2007 | Drug Metab. Dispos. | pmid:17494643 |
Yang SL et al. | Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. | 2007 | Pharmacology | pmid:17496435 |
Liebhart J et al. | Production of leukotriene C4 by peripheral blood leukocytes stimulated with anti-fcepsilonRI antibody, PMA, and fMLP does not correlate with irreversible airway obstruction in asthmatics. | 2007 | J Investig Allergol Clin Immunol | pmid:17323856 |
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Farias SE et al. | Transcellular biosynthesis of cysteinyl leukotrienes in rat neuronal and glial cells. | 2007 | J. Neurochem. | pmid:17711426 |
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