Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Burghardt JS et al. | Lipid mediators in oxygen-induced airway remodeling and hyperresponsiveness in newborn rats. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8887572 |
Hisamatsu K et al. | Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa. | 1996 | Prostaglandins | pmid:8900445 |
Güllüoğlu BM et al. | Endothelin release is augmented with captopril in rat ischemia-reperfusion injury of the liver. | 1996 | Res Exp Med (Berl) | pmid:8903098 |
Nishisho T et al. | Experimental and clinical studies of eicosanoids in cerebrospinal fluid after spinal cord injury. | 1996 | Neurosurgery | pmid:8905750 |
Hong JT and Glauert HP | Comitogenicity of eicosanoids and the peroxisome proliferator ciprofibrate in cultured rat hepatocytes. | 1996 | J. Cell. Physiol. | pmid:8908198 |
Gao M et al. | Reconstitution of ATP-dependent leukotriene C4 transport by Co-expression of both half-molecules of human multidrug resistance protein in insect cells. | 1996 | J. Biol. Chem. | pmid:8910374 |
Jutel M et al. | Influence of bee venom immunotherapy on degranulation and leukotriene generation in human blood basophils. | 1996 | Clin. Exp. Allergy | pmid:8911695 |
Omar HM et al. | Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury. | 1996 | Inflamm. Res. | pmid:8912018 |
Müller D et al. | Bile ductular proliferation and altered leukotriene elimination in thioacetamide-induced fibrosis of rat liver. | 1996 | J. Hepatol. | pmid:8912155 |
Sedgwick JB et al. | Effect of isolation protocol on eosinophil function: Percoll gradients versus immunomagnetic beads. | 1996 | J. Immunol. Methods | pmid:8914593 |
Breil I et al. | Alteration of n-3 fatty acid composition in lung tissue after short-term infusion of fish oil emulsion attenuates inflammatory vascular reaction. | 1996 | Crit. Care Med. | pmid:8917042 |
Kang BC et al. | Experimental asthma developed by room air contamination with cockroach allergen. | 1996 | Int. Arch. Allergy Immunol. | pmid:8917126 |
Pulaski L et al. | Identification of the multidrug-resistance protein (MRP) as the glutathione-S-conjugate export pump of erythrocytes. | 1996 | Eur. J. Biochem. | pmid:8917467 |
Ganbo T et al. | The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. | 1995 | Rhinology | pmid:8919211 |
Muñoz NM et al. | Eosinophil VLA-4 binding to fibronectin augments bronchial narrowing through 5-lipoxygenase activation. | 1996 | Am. J. Physiol. | pmid:8928818 |
Willburger RE et al. | Inhibition of eicosanoid release from synovial organ culture by incubation with tepoxalin and its acid metabolite. | 1996 | Prostaglandins | pmid:8936587 |
Richter L et al. | Increased biliary secretion of cysteinyl-leukotrienes in human bile duct obstruction. | 1996 | J. Hepatol. | pmid:8938552 |
Sun H et al. | Expression and characterization of the multidrug resistance-associated protein in insect cells infected with a recombinant baculovirus. | 1996 | Oncol. Res. | pmid:8938792 |
Lane SJ and Lee TH | Mast cell effector mechanisms. | 1996 | J. Allergy Clin. Immunol. | pmid:8939179 |
Namovic MT et al. | Pharmacological modulation of eosinophil influx into the lungs of Brown Norway rats. | 1996 | Eur. J. Pharmacol. | pmid:8960868 |
Ionac M et al. | Oxaceprol, an atypical inhibitor of inflammation and joint damage. | 1996 | Pharmacol. Res. | pmid:8971960 |
Leier I et al. | Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homolog of the multidrug-resistance protein. | 1996 | Eur. J. Biochem. | pmid:8973633 |
Maclouf J et al. | Consequences of transcellular biosynthesis of leukotriene C4 on organ function. | 1996 | Haemostasis | pmid:8979109 |
Bäck M et al. | The cysteinyl-leukotriene receptor antagonist BAY u9773 is a competitive antagonist of leukotriene C4 in the guinea-pig ileum. | 1996 | Eur. J. Pharmacol. | pmid:8982726 |
Campbell A et al. | Overview of allergic mechanisms. Ebastine has more than an antihistamine effect. | 1996 | Drugs | pmid:8983912 |
Akasaka R et al. | Effects of three different Ca(2+)-ATPase inhibitors on Ca2+ response and leukotriene release in RBL-2H3 cells. | 1996 | Inflamm. Res. | pmid:8988402 |
Kobayashi S et al. | [Inhibitory effect of ONO-1078, a novel leukotriene receptor antagonist, on human peripheral blood eosinophils]. | 1996 | Arerugi | pmid:8990528 |
Garcia C et al. | Effects of synthetic peptido-leukotrienes on bone resorption in vitro. | 1996 | J. Bone Miner. Res. | pmid:8992883 |
Dhillon HS et al. | Regional generation of leukotriene C4 after experimental brain injury in anesthetized rats. | 1996 | J. Neurotrauma | pmid:9002063 |
Sare M et al. | The effects of indomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandin E2 and leukotriene C4 levels after mesenteric ischemia-reperfusion injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014215 |
Gissurarson SR et al. | Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig taenia coli. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023290 |
Schuligoi R et al. | Release of calcitonin gene-related peptide in cardiac anaphylaxis. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9050016 |
Damtew B and Spagnuolo PJ | Leukotriene C4 from vascular endothelium enhances neutrophil adhesiveness. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051719 |
Sumizawa T et al. | Reversal of multidrug resistance-associated protein-mediated drug resistance by the pyridine analog PAK-104P. | 1997 | Mol. Pharmacol. | pmid:9058594 |
de Paulis A et al. | Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs. | 1997 | Arthritis Rheum. | pmid:9082935 |
Scoggan KA et al. | Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes. | 1997 | J. Biol. Chem. | pmid:9092565 |
Puder M and Soberman RJ | Glutathione conjugates recognize the Rossmann fold of glyceraldehyde-3-phosphate dehydrogenase. | 1997 | J. Biol. Chem. | pmid:9099752 |
Wang D et al. | An approach to the understanding of the nasal early-phase reaction induced by nasal allergen challenge. | 1997 | Allergy | pmid:9105520 |
Gagari E et al. | Differential release of mast cell interleukin-6 via c-kit. | 1997 | Blood | pmid:9108382 |
Madon J et al. | Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. | 1997 | FEBS Lett. | pmid:9109389 |
Zeltsman D et al. | Pathophysiologic plasma levels of leukotriene C4 in relation to the hemodynamic dysfunction and mediator release of graded bacteremia. | 1997 | Shock | pmid:9110414 |
Sala A et al. | Pharmacological modulation of human platelet leukotriene C4-synthase. | 1997 | Biochem. Pharmacol. | pmid:9113110 |
Hsieh KH | Evaluation of efficacy of traditional Chinese medicines in the treatment of childhood bronchial asthma: clinical trial, immunological tests and animal study. Taiwan Asthma Study Group. | 1996 | Pediatr Allergy Immunol | pmid:9116877 |
Ishizuka Y et al. | Effect of 1,6-dihydro-2[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidineca rboxyli c acid on ethanol-induced microvascular injury in rats. | 1996 | Arzneimittelforschung | pmid:9125278 |
el-Ahmady O et al. | Elevated concentrations of interleukins and leukotriene in response to Mycobacterium tuberculosis infection. | 1997 | Ann. Clin. Biochem. | pmid:9133249 |
Bureau MF et al. | 5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. | 1997 | Eur. J. Pharmacol. | pmid:9137918 |
Carter BZ et al. | Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice. | 1997 | J. Biol. Chem. | pmid:9139674 |
Nguyen T and Gupta S | Leukotriene C4 secretion from normal murine mast cells by a probenecid-sensitive and multidrug resistance-associated protein-independent mechanism. | 1997 | J. Immunol. | pmid:9144509 |
Bozkurt S et al. | The cytoprotective effect of iloprost against carbon tetrachloride induced necrosis in rat liver. | 1997 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9144840 |
KuÅŸtimur S et al. | Effect of nordihydroguaretic acid and fluconazole on the LTC4/PGE2 ratio in the kidney of mice damaged by Candida albicans. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150373 |