Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ma K et al. | Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway. | 2009 | Eur. J. Pharmacol. | pmid:19087874 |
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Mueller CF et al. | Angiotensin II triggers release of leukotriene C4 in vascular smooth muscle cells via the multidrug resistance-related protein 1. | 2010 | Mol. Cell. Biochem. | pmid:19685171 |
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Zhang T et al. | Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma. | 2010 | Phytother Res | pmid:19998324 |
Kawamura F et al. | Effects of menadione, a reactive oxygen generator, on leukotriene secretion from RBL-2H3 cells. | 2010 | Biol. Pharm. Bull. | pmid:20460770 |
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Kitahata Y et al. | Prolonged culture of mast cells with high-glucose medium enhances the Fc epsilon RI-mediated degranulation response and leukotriene C4 production. | 2010 | Int. Arch. Allergy Immunol. | pmid:20523060 |
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Okubo M et al. | Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors. | 2010 | Mol Pain | pmid:20846451 |
Korzekwa AJ et al. | Leukotrienes modulate secretion of progesterone and prostaglandins during the estrous cycle and early pregnancy in cattle: an in vivo study. | 2010 | Reproduction | pmid:20813877 |
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Szabó Z et al. | ABCC6 does not transport adenosine - relevance to pathomechanism of pseudoxanthoma elasticum. | 2011 | Mol. Genet. Metab. | pmid:21813308 |
Kim SJ et al. | Manassantin A isolated from Saururus chinensis inhibits 5-lipoxygenase-dependent leukotriene C4 generation by blocking mitogen-activated protein kinase activation in mast cells. | 2011 | Biol. Pharm. Bull. | pmid:22040894 |
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