LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Van Dijk JP et al. | Nicotine inhibits cytokine synthesis by mouse colonic mucosa. | 1995 | Eur. J. Pharmacol. | pmid:7664807 |
| Prié S et al. | Leukotriene C4 receptors on guinea pig tracheocytes. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7562565 |
| Votta BJ and Bertolini DR | Cytokine suppressive anti-inflammatory compounds inhibit bone resorption in vitro. | 1994 Sep-Oct | Bone | pmid:7980964 |
| Munoz NM et al. | Beta adrenergic modulation of formyl-methionine-leucine-phenylalanine-stimulated secretion of eosinophil peroxidase and leukotriene C4. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301549 |
| Sathirakul K et al. | Multiple transport systems for organic anions across the bile canalicular membrane. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301595 |
| Metters KM et al. | Microsomal glutathione S-transferase is the predominant leukotriene C4 binding site in cellular membranes. | 1994 | J. Biol. Chem. | pmid:8175695 |
| Tudhope SR et al. | BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. | 1994 | Eur. J. Pharmacol. | pmid:7698171 |
| Ducep JB et al. | Synthesis of 5- and 6-fluoro derivatives of 5,8,14-eicosatrienoic and 5,8,11,14-eicosatetraenoic acids. Effects of fluorinated arachidonic acids on leukotriene C4 production by macrophages. | 1994 | Bioorg. Med. Chem. | pmid:7922133 |
| Schauer U et al. | Blood eosinophils, leukotriene C4 generation, and bronchial hyperreactivity in formerly preterm infants. | 1994 | Arch. Dis. Child. | pmid:7726609 |
| Wardle TD and Turnberg LA | Potential role for interleukin-1 in the pathophysiology of ulcerative colitis. | 1994 | Clin. Sci. | pmid:8033515 |
| Kargman S et al. | Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells. | 1994 | Mol. Pharmacol. | pmid:8190095 |
| Shimizu T et al. | Leukotriene B4 and C4 generation by blood leukocytes after ex vivo stimulation by Ca-ionophore and opsonized zymosan in children with atopic dermatitis. | 1994 | Pediatr Allergy Immunol | pmid:8087194 |
| Mayatepek E et al. | Impaired synthesis of lipoxygenase products in glutathione synthetase deficiency. | 1994 | Pediatr. Res. | pmid:8190517 |
| Willburger RE and Wittenberg RH | Prostaglandin release from lumbar disc and facet joint tissue. | 1994 | Spine | pmid:7825047 |
| Wang D et al. | Concentrations of chemical mediators in nasal secretions of patients with hay fever during natural allergen exposure. | 1994 | Acta Otolaryngol. | pmid:7825440 |
| Goulet JL et al. | Altered inflammatory responses in leukotriene-deficient mice. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7809134 |
| Müller M et al. | Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7809167 |
| HasanoÄŸlu E et al. | The role of prostanoids in the complications of extracorporeal shock wave lithotripsy (ESWL) in children. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846111 |
| Hamasaki Y et al. | Inhibition by dexamethasone of retinoic acid-induced enhancement of leukotriene C4 synthesis in rat basophilic leukemia-1 cells. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:8018338 |
| Leff AR | Inflammatory mediation of airway hyperresponsiveness by peripheral blood granulocytes. The case for the eosinophil. | 1994 | Chest | pmid:7924496 |
| Büchler M et al. | Functional reconstitution of ATP-dependent transporters from the solubilized hepatocyte canalicular membrane. | 1994 | Eur. J. Biochem. | pmid:7925347 |
| Anwar AR et al. | Adhesion to fibronectin primes eosinophils via alpha 4 beta 1 (VLA-4). | 1994 | Immunology | pmid:7927493 |
| Aktan AO et al. | Does PGE2 act as a mediator for endothelin release? | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7511821 |
| YeÄŸen C et al. | Effect of verapamil and iloprost (ZK 36374) on endothelin release after mesenteric ischemia-reperfusion injury. | 1994 | Eur Surg Res | pmid:7516292 |
| Wettstein M and Häussinger D | [Effect of hypoxia on nitric oxide formation and leukotriene metabolism in the perfused rat liver]. | 1994 | Zentralbl Chir | pmid:7517604 |
| Bürgi B et al. | The degradation product of the C5a anaphylatoxin C5adesarg retains basophil-activating properties. | 1994 | Eur. J. Immunol. | pmid:7517876 |
| Sainte-Laudy J et al. | [Demonstration of sulfite-group-specific IgE in patients with intolerance to preservatives]. | 1994 | Allerg Immunol (Paris) | pmid:7518236 |
| Miadonna A et al. | Modulation of allergen-induced nasal symptoms and mediator release by treatment with N-acetyl-aspartyl-glutamate (ZY15106). | 1994 | Eur. J. Clin. Pharmacol. | pmid:7518775 |
| Yamamura H et al. | Endothelin-1 induces release of histamine and leukotriene C4 from mouse bone marrow-derived mast cells. | 1994 | Eur. J. Pharmacol. | pmid:7522171 |
| Tsopanoglou NE et al. | Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction. | 1994 | Eur. J. Pharmacol. | pmid:7523148 |
| Tedeschi A et al. | Nasal eosinophilia induced by PAF-acether is accompanied by the release of eosinophil cationic protein. | 1994 | Eur. Respir. J. | pmid:7525344 |
| Ramachers U et al. | Direct effects of second-generation H1-receptor antagonists on the activation of human basophils. | 1994 | Agents Actions | pmid:7526656 |
| Mita H et al. | [Release of chemical mediators in the conjunctival lavage fluids after eye provocation with allergen or compound 48/80]. | 1994 | Arerugi | pmid:7526828 |
| Shimizu T et al. | Inhibitory effects of theophylline, terbutaline, and hydrocortisone on leukotriene B4 and C4 generation by human leukocytes in vitro. | 1994 | Pediatr. Pulmonol. | pmid:7800427 |
| Abela A and Daniel EE | Neural and myogenic effects of leukotrienes C4, D4, and E4 on canine bronchial smooth muscle. | 1994 | Am. J. Physiol. | pmid:8179018 |
| Pintos-Morell G et al. | Altered leukotriene generation in leukocytes from cystinotic children. | 1994 | Pediatr. Res. | pmid:7877883 |
| Thioudellet C et al. | Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. | 1994 | Eur. J. Biochem. | pmid:7913033 |
| Jedlitschky G et al. | ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. | 1994 | Cancer Res. | pmid:7915193 |
| Kapuściński A | Leukotriene C4 in the rat brain after resuscitation from clinical death. | 1994 | Folia Neuropathol | pmid:7922113 |
| Ohemeng KA et al. | Novel bishydroxamic acids as 5-lipoxygenase inhibitors. | 1994 | Bioorg. Med. Chem. | pmid:7922131 |
| Busse WW and Sedgwick JB | Eosinophil eicosanoid relations in allergic inflammation of the airways. | 1994 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7771338 |
| Shimizu T et al. | Leukotriene B4 and C4 generation by small intestinal mucosa in children with coeliac disease. | 1994 | Digestion | pmid:8063028 |
| Gardiner PJ et al. | Leukotriene receptors and their selective antagonists. | 1994 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7771349 |
| Keppler D et al. | Transport and metabolism of leukotrienes. | 1994 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7771352 |
| Laviolette M et al. | Effects of inhaled steroids on blood eosinophils in moderate asthma. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8031001 |
| Cotti E and Torabinejad M | Detection of leukotriene C4 in human periradicular lesions. | 1994 | Int Endod J | pmid:8034369 |
| Lam BK et al. | Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8052639 |
| Yamada N et al. | Pharmacological profile of the novel, potent and selective peptide leukotriene antagonist (E)-2,2-diethyl-3'-[2-[2-(4-isopropyl)thiazolyl]ethenyl]succinanilic acid. | 1994 | Arzneimittelforschung | pmid:8053974 |
| Bando T et al. | Inhibitory effect of aerosol administration of a sulfidopeptide leukotriene antagonist on bronchoconstriction induced by antigen inhalation in guinea pigs. | 1994 | Arzneimittelforschung | pmid:8053975 |
| Maclouf J et al. | Leukotriene C4 formation by transcellular biosynthesis. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8017763 |