Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Huang SC | Leukotriene-induced contraction is mediated by cysteinyl leukotriene receptor CysLT1 in guinea pig fundus but by CysLT1 and CysLT2 in antrum. | 2011 | Life Sci. | pmid:21396378 |
Yan D et al. | Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT₂) agonist, N-methyl-leukotriene C₄, in calcium reporter and β arrestin assays. | 2011 | Mol. Pharmacol. | pmid:21078884 |
Hung ND et al. | Oral administration of 2-docosahexaenoyl lysophosphatidylcholine displayed anti-inflammatory effects on zymosan A-induced peritonitis. | 2011 | Inflammation | pmid:20490641 |
Mackay GA and Stewart AG | R2D(2) for C(4)Eo: an 'alliance' of PGD(2) receptors is required for LTC(4) production by human eosinophils. | 2011 | Br. J. Pharmacol. | pmid:21426314 |
Bridges CC et al. | MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21134393 |
Becher UM et al. | Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury. | 2011 | J. Mol. Cell. Cardiol. | pmid:21112334 |
Zhu Y and Bertics PJ | Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils. | 2011 | J. Immunol. | pmid:21106848 |
Szabó Z et al. | ABCC6 does not transport adenosine - relevance to pathomechanism of pseudoxanthoma elasticum. | 2011 | Mol. Genet. Metab. | pmid:21813308 |
Mesquita-Santos FP et al. | Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils. | 2011 | Br. J. Pharmacol. | pmid:20973774 |
Megaraj V et al. | Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2). | 2011 | Pharmacogenet. Genomics | pmid:21691255 |
Hirata H et al. | Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma. | 2011 | Clin. Exp. Allergy | pmid:21429049 |
Wickham S et al. | Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. | 2011 | Anal. Biochem. | pmid:21447318 |
Nagy E et al. | Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts. | 2011 | Circulation | pmid:21403093 |
Saino H et al. | The catalytic architecture of leukotriene C4 synthase with two arginine residues. | 2011 | J. Biol. Chem. | pmid:21454538 |
He P et al. | Oxidative stress suppresses cysteinyl leukotriene generation by mouse bone marrow-derived mast cells. | 2011 | J. Biol. Chem. | pmid:21233206 |
Esser J et al. | Zymosan suppresses leukotriene Câ‚„ synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors. | 2011 | FASEB J. | pmid:21228223 |
Zhang Y et al. | [Effects of polydatin on bleomycin-induced pulmonary fibrosis in rats]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22368872 |
Brochu-Bourque A et al. | Differential signaling defects associated with the M201V polymorphism in the cysteinyl leukotriene type 2 receptor. | 2011 | J. Pharmacol. Exp. Ther. | pmid:20966037 |
Aung G et al. | Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. | 2011 | Immunology | pmid:21214543 |
Skazik C et al. | Active transport of contact allergens in human monocyte-derived dendritic cells is mediated by multidrug resistance related proteins. | 2011 | Arch. Biochem. Biophys. | pmid:21284934 |
Iram SH and Cole SP | Expression and function of human MRP1 (ABCC1) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2. | 2011 | J. Biol. Chem. | pmid:21177244 |
Oh YC et al. | Anti-allergic effects of sinomenine by inhibition of prostaglandin Dâ‚‚ and leukotriene Câ‚„ in mouse bone marrow-derived mast cells. | 2011 | Immunopharmacol Immunotoxicol | pmid:21080779 |
Hung ND et al. | Mechanisms for anti-inflammatory effects of 1-[15(S)-hydroxyeicosapentaenoyl] lysophosphatidylcholine, administered intraperitoneally, in zymosan A-induced peritonitis. | 2011 | Br. J. Pharmacol. | pmid:21091644 |
Kim SJ et al. | Manassantin A isolated from Saururus chinensis inhibits 5-lipoxygenase-dependent leukotriene C4 generation by blocking mitogen-activated protein kinase activation in mast cells. | 2011 | Biol. Pharm. Bull. | pmid:22040894 |
Carnini C et al. | Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor. | 2011 | FASEB J. | pmid:21753081 |
Wang JL et al. | [The mechanism of airway inflammation in eosinophilic bronchitis and cough variant asthma]. | 2011 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:21781515 |
Furukawa M et al. | Terpenoids and phenethyl glucosides from Hyssopus cuspidatus (Labiatae). | 2011 | Phytochemistry | pmid:21893325 |
Alvarez C et al. | Leukotriene C(4) prevents the complete maturation of murine dendritic cells and modifies interleukin-12/interleukin-23 balance. | 2011 | Immunology | pmid:21896013 |
Jin M et al. | Luteolin-7-O-glucoside suppresses leukotriene C(4) production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cγ1 in activated mouse bone marrow-derived mast cells. | 2011 | Biol. Pharm. Bull. | pmid:21720009 |
Dartt DA et al. | Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. | 2011 | J. Immunol. | pmid:21357260 |
Eun JC et al. | The 5-lipoxygenase pathway is required for acute lung injury following hemorrhagic shock. | 2012 | Shock | pmid:22392149 |
Eaton A et al. | Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression. | 2012 | J. Mol. Med. | pmid:22527886 |
Maurer M and Church MK | Inflammatory skin responses induced by icatibant injection are mast cell mediated and attenuated by H(1)-antihistamines. | 2012 | Exp. Dermatol. | pmid:22142018 |
Dannull J et al. | Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function. | 2012 | Blood | pmid:22323449 |
Fugazzola M et al. | Non-genomic action of beclomethasone dipropionate on bronchoconstriction caused by leukotriene C4 in precision cut lung slices in the horse. | 2012 | BMC Vet. Res. | pmid:22963524 |
Hong F and Yang S | Ischemic preconditioning decreased leukotriene C4 formation by depressing leukotriene C4 synthase expression and activity during hepatic I/R injury in rats. | 2012 | J. Surg. Res. | pmid:22921920 |
Liu W et al. | Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22982073 |
Lu Y et al. | Saucerneol D inhibits eicosanoid generation and degranulation through suppression of Syk kinase in mast cells. | 2012 | Food Chem. Toxicol. | pmid:22982805 |
Rinaldo-Matthis A et al. | Pre-steady-state kinetic characterization of thiolate anion formation in human leukotriene Câ‚„ synthase. | 2012 | Biochemistry | pmid:22217203 |
Ng SW et al. | Cysteinyl leukotriene type I receptor desensitization sustains Ca2+-dependent gene expression. | 2012 | Nature | pmid:22230957 |
Chae HS and Chin YW | Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells. | 2012 | Immunopharmacol Immunotoxicol | pmid:21854102 |
Li X et al. | Natural vanadium-containing Jeju groundwater inhibits immunoglobulin E-mediated anaphylactic reaction and suppresses eicosanoid generation and degranulation in bone marrow derived-mast cells. | 2012 | Biol. Pharm. Bull. | pmid:22293352 |
Lester GD and Rice BL | Effects of leukotriene C4 on the bioelectric properties and ion transport of equine tracheal epithelium. | 2012 | Am. J. Vet. Res. | pmid:23176432 |
Pelclová D et al. | Leukotrienes B4, C4, D4 and E4 in the exhaled breath condensate (EBC), blood and urine in patients with pneumoconiosis. | 2012 | Ind Health | pmid:22785421 |
Secatto A et al. | 5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection. | 2012 | PLoS ONE | pmid:22448213 |
Wu L et al. | Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury. | 2012 | J. Mol. Neurosci. | pmid:22661361 |
Sodani K et al. | Multidrug resistance associated proteins in multidrug resistance. | 2012 | Chin J Cancer | pmid:22098952 |
Jiang W et al. | UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP. | 2012 | Drug Metab. Dispos. | pmid:22071170 |
Chae HS et al. | Anti-allergic effect of a chloroform-soluble extract of Cinnamomum cambodianum in bone marrow-derived mast cells. | 2012 | Immunopharmacol Immunotoxicol | pmid:22229445 |
Piotrowska-Tomala KK et al. | Lipopolysaccharides, cytokines, and nitric oxide affect secretion of prostaglandins and leukotrienes by bovine mammary gland epithelial cells. | 2012 | Domest. Anim. Endocrinol. | pmid:22608768 |