Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Wang D et al. | An approach to the understanding of the nasal early-phase reaction induced by nasal allergen challenge. | 1997 | Allergy | pmid:9105520 |
Piette V et al. | Sinus CT scans and mediator release in nasal secretions after nasal challenge with cypress pollens. | 2004 | Allergy | pmid:15230820 |
Chavis C et al. | Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity. | 1997 | Allergy | pmid:9201374 |
Zuberbier T et al. | Histamine releasability of basophils and skin mast cells in chronic urticaria. | 1996 | Allergy | pmid:8721524 |
Gurzeler U et al. | In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8. | 2013 | Allergy | pmid:23590216 |
Wang DY et al. | The upper and lower airway responses to nasal challenge with house-dust mite Blomia tropicalis. | 2003 | Allergy | pmid:12580812 |
Kupczyk M et al. | Lipoxin A4 generation is decreased in aspirin-sensitive patients in lysine-aspirin nasal challenge in vivo model. | 2009 | Allergy | pmid:19385948 |
Gulliksson M et al. | Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells. | 2006 | Allergy | pmid:17073880 |
Takafuji S et al. | Release of granule proteins from human eosinophils stimulated with mast-cell mediators. | 1998 | Allergy | pmid:9821474 |
Kowalski ML et al. | Inhibition of nasal polyp mast cell and eosinophil activation by desloratadine. | 2005 | Allergy | pmid:15575935 |
Schauer U et al. | Blood eosinophils, eosinophil-derived proteins, and leukotriene C4 generation in relation to bronchial hyperreactivity in children with atopic dermatitis. | 1995 | Allergy | pmid:7604934 |
Kalayci O et al. | ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. | 2006 | Allergy | pmid:16364163 |
Jordan TR et al. | An approach of immunoneurological aspects in nasal allergic late phase. | 2005 Sep-Oct | Allergy Asthma Proc | pmid:16450573 |
Kramer MF et al. | Factors contributing to nasal allergic late phase eosinophilia. | 2006 May-Jun | Am J Otolaryngol | pmid:16647984 |
Klapan I et al. | Arachidonic acid metabolites and sinonasal polyposis. I. Possible prognostic value. | 1995 Nov-Dec | Am J Otolaryngol | pmid:8572256 |
Malaviya R and Uckun FM | Leflunomide metabolite analogue alpha-cyano-beta-hydroxy-beta-methyl-N-[3-(trifluoromethyl)phenyl]propenamide inhibits IgE/FcepsilonRI receptor-mediated mast cell leukotriene release and allergic asthma in mice. | 2001 Sep-Oct | Am J Ther | pmid:11550070 |
Takase B et al. | Effects of bepridil on silent myocardial ischemia and eicosanoid metabolism in chronic stable angina pectoris after healing of myocardial infarction. | 1994 | Am. J. Cardiol. | pmid:8198031 |
Sternfeld M et al. | The role of acupuncture in asthma: changes in airways dynamics and LTC4 induced LAI. | 1989 | Am. J. Chin. Med. | pmid:2633615 |
Song HH et al. | Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells. | 2012 | Am. J. Chin. Med. | pmid:22928836 |
Dellon ES et al. | Diagnostic utility of major basic protein, eotaxin-3, and leukotriene enzyme staining in eosinophilic esophagitis. | 2012 | Am. J. Gastroenterol. | pmid:22777338 |