Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Romero R et al. | Increased amniotic fluid leukotriene C4 concentration in term human parturition. | 1988 | Am. J. Obstet. Gynecol. | pmid:3421265 |
Gronert K et al. | Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. | 2001 | Am. J. Pathol. | pmid:11141472 |
John AE et al. | Temporal production of CCL28 corresponds to eosinophil accumulation and airway hyperreactivity in allergic airway inflammation. | 2005 | Am. J. Pathol. | pmid:15681819 |
Hamann KJ et al. | Effects of activated eosinophils cultured from human umbilical cord blood on guinea pig trachealis. | 1993 | Am. J. Physiol. | pmid:8214090 |
Niinuma K et al. | Primary active transport of organic anions on bile canalicular membrane in humans. | 1999 | Am. J. Physiol. | pmid:10330006 |
Huber W et al. | Leukotriene B4 and C4 production in isolated rat gastric mucosal cells. | 1993 | Am. J. Physiol. | pmid:8279553 |
Miller DS et al. | Excretory transport of xenobiotics by dogfish shark rectal gland tubules. | 1998 | Am. J. Physiol. | pmid:9728065 |
Grønbech JE and Lacy ER | Role of gastric blood flow in impaired defense and repair of aged rat stomachs. | 1995 | Am. J. Physiol. | pmid:7491966 |
Brady HR et al. | Lipoxygenase product formation and cell adhesion during neutrophil-glomerular endothelial cell interaction. | 1995 | Am. J. Physiol. | pmid:7840235 |
Carvalho-Tavares J et al. | Assessment of the mechanism of juxtacrine activation and adhesion of leukocytes in liver microcirculation. | 1999 | Am. J. Physiol. | pmid:10198324 |
Fiorucci S et al. | Effect of NSAIDs on pepsinogen secretion and calcium mobilization in isolated chief cells. | 1995 | Am. J. Physiol. | pmid:7611418 |
Muñoz NM et al. | Augmentation of eosinophil degranulation and LTC(4) secretion by integrin-mediated endothelial cell adhesion. | 1999 | Am. J. Physiol. | pmid:10516222 |
Ohtsuki T et al. | Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain. | 1995 | Am. J. Physiol. | pmid:7900879 |
Sato E et al. | Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. | 1998 | Am. J. Physiol. | pmid:9609736 |
Abela A and Daniel EE | Neural and myogenic effects of leukotrienes C4, D4, and E4 on canine bronchial smooth muscle. | 1994 | Am. J. Physiol. | pmid:8179018 |
Ganbo T et al. | Leukotriene C4 inhibits ciliary activity in the presence of gamma-glutamyl transpeptidase. | 1996 | Am. J. Physiol. | pmid:8770059 |
Muñoz NM et al. | Eosinophil VLA-4 binding to fibronectin augments bronchial narrowing through 5-lipoxygenase activation. | 1996 | Am. J. Physiol. | pmid:8928818 |
Liu S et al. | Neuroimmune interactions in guinea pig stomach and small intestine. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12388180 |
Oleschuk CJ et al. | Substitution of Trp1242 of TM17 alters substrate specificity of human multidrug resistance protein 3. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12388190 |
Keitel V et al. | A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2). | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12388192 |