Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Robbiani DF et al. | The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. | 2000 | Cell | pmid:11114332 |
Schmidt DT et al. | The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways. | 2000 | Br. J. Pharmacol. | pmid:11139438 |
Gronert K et al. | Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. | 2001 | Am. J. Pathol. | pmid:11141472 |
Nobukata H et al. | Long-term administration of highly purified eicosapentaenoic acid ethyl ester improves the dysfunction of vascular endothelial and smooth muscle cells in male WBN/Kob rats. | 2000 | Metab. Clin. Exp. | pmid:11145121 |
Setoguchi H et al. | Leukotriene C(4) enhances the contraction of porcine tracheal smooth muscle through the activation of Y-27632, a rho kinase inhibitor, sensitive pathway. | 2001 | Br. J. Pharmacol. | pmid:11156567 |
Kivity S et al. | Eosinophil influx into the airways in patients with exercise-induced asthma. | 2000 | Respir Med | pmid:11192956 |
Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |
Amann R et al. | Effects of COX-1 and COX-2 inhibitors on eicosanoid biosynthesis and the release of substance P from the guinea-pig isolated perfused lung. | 2001 | Inflamm. Res. | pmid:11235022 |
Downey P et al. | Renal concentrating defect in mice lacking group IV cytosolic phospholipase A(2). | 2001 | Am. J. Physiol. Renal Physiol. | pmid:11249852 |
Picado C and Valero A | COX-1 sparing drugs in aspirin-sensitive asthma. | 2001 | Clin. Exp. Allergy | pmid:11251618 |
Okayama Y et al. | A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI. | 2001 | J. Immunol. | pmid:11254731 |
Bandeira-Melo C et al. | Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils. | 2001 | J. Biol. Chem. | pmid:11274187 |
Zhang DW et al. | Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines. | 2001 | J. Biol. Chem. | pmid:11278596 |
Ito K et al. | Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport. | 2001 | J. Biol. Chem. | pmid:11278867 |
Schroeder JT et al. | Human basophils: mediator release and cytokine production. | 2001 | Adv. Immunol. | pmid:11293121 |
Eppihimer MJ and Schaub RG | Soluble P-selectin antagonist mediates rolling velocity and adhesion of leukocytes in acutely inflamed venules. | 2001 | Microcirculation | pmid:11296849 |
Leslie EM et al. | Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. | 2001 | Mol. Pharmacol. | pmid:11306701 |
Sjöström M et al. | Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. | 2001 | Eur. J. Biochem. | pmid:11322876 |
DÃaz Lanza AM et al. | Lignan and phenylpropanoid glycosides from Phillyrea latifolia and their in vitro anti-inflammatory activity. | 2001 | Planta Med. | pmid:11345691 |
Oliveira SH et al. | SCF-induced airway hyperreactivity is dependent on leukotriene production. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11350804 |