Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kuehn HS et al. | The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells. | 2008 | J. Immunol. | pmid:19017959 |
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Yang SH and Yu CL | Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis. | 2008 | J Ethnopharmacol | pmid:17980528 |
Hattori Y et al. | Gastric mucosal protection against ethanol by EP2 and EP4 signaling through the inhibition of leukotriene C4 production. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17947453 |
Slot AJ et al. | Modulation of human multidrug resistance protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) transport activities by endogenous and exogenous glutathione-conjugated catechol metabolites. | 2008 | Drug Metab. Dispos. | pmid:18079363 |
Devakumar A et al. | Structural analysis of leukotriene C4 isomers using collisional activation and 157 nm photodissociation. | 2008 | J. Am. Soc. Mass Spectrom. | pmid:18024058 |
Thompson C et al. | Signaling by the cysteinyl-leukotriene receptor 2. Involvement in chemokine gene transcription. | 2008 | J. Biol. Chem. | pmid:18048362 |
Mustafa FB et al. | Honeybee venom secretory phospholipase A2 induces leukotriene production but not histamine release from human basophils. | 2008 | Clin. Exp. Immunol. | pmid:18005261 |
Wang J et al. | Does leukotriene affect intracellular glutathione redox state in cultured human airway epithelial cells? | 2008 | Antioxid. Redox Signal. | pmid:18199004 |
Feltenmark S et al. | Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18184802 |
Heredi-Szabo K et al. | Characterization of 5(6)-carboxy-2,'7'-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4. | 2008 | J Biomol Screen | pmid:18349419 |
Létourneau IJ et al. | Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter. | 2008 | Biochem. Pharmacol. | pmid:18336795 |
Cao F et al. | Mrp2-related efflux of scutellarin in the intestinal absorption in rats. | 2008 | Pharmazie | pmid:18271309 |
Ito Y et al. | Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. | 2008 | BMB Rep | pmid:18315950 |
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Bandler PE et al. | Identification of regions required for apical membrane localization of human multidrug resistance protein 2. | 2008 | Mol. Pharmacol. | pmid:18381564 |
Rius M et al. | ATP-dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4). | 2008 | J. Pharmacol. Exp. Ther. | pmid:17959747 |
Korzekwa A et al. | The influence of tumor necrosis factor alpha (TNF) on the secretory function of bovine corpus luteum: TNF and its receptors expression during the estrous cycle. | 2008 | Reprod Biol | pmid:19092986 |
Zheng MS et al. | Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity. | 2008 | Arch. Pharm. Res. | pmid:18409044 |
Moon TC et al. | The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2008 | Arch. Pharm. Res. | pmid:18365692 |
Mochizuki Y et al. | Suppressive activity of epinastine hydrochloride on eosinophil activation in vitro. | 2008 Jan-Feb | In Vivo | pmid:18396776 |
Theron AJ et al. | Leukotrienes C4 and D4 sensitize human neutrophils for hyperreactivity to chemoattractants. | 2009 | Inflamm. Res. | pmid:19184354 |
Di Capite J et al. | Intercellular Ca2+ wave propagation involving positive feedback between CRAC channels and cysteinyl leukotrienes. | 2009 | FASEB J. | pmid:18978154 |
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Westergren VS et al. | Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis. | 2009 | Clin. Exp. Allergy | pmid:19364335 |
Zehnpfennig B et al. | Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. | 2009 | Biochemistry | pmid:19334674 |
Athayde LA et al. | Blocking central leukotrienes synthesis affects vasopressin release during sepsis. | 2009 | Neuroscience | pmid:19285113 |
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