Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Willburger RE et al. | Inhibition of eicosanoid release from synovial organ culture by incubation with tepoxalin and its acid metabolite. | 1996 | Prostaglandins | pmid:8936587 |
Dhillon HS et al. | Regional generation of leukotriene C4 after experimental brain injury in anesthetized rats. | 1996 | J. Neurotrauma | pmid:9002063 |
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Planquois JM et al. | Differential inhibition by selective phosphodiesterase inhibitors of antigen, LTC4 and histamine-induced contraction of guinea-pig isolated trachea. | 1996 | Pulm Pharmacol | pmid:9160414 |
Büchler M et al. | cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. | 1996 | J. Biol. Chem. | pmid:8662992 |
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Zuberbier T et al. | Histamine releasability of basophils and skin mast cells in chronic urticaria. | 1996 | Allergy | pmid:8721524 |
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Paul S et al. | ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8692921 |
Przylipiak A et al. | Role of leukotriene C4 in follicle-stimulating hormone (FSH) secretion in female rat pituitary. | 1996 | Gynecol. Endocrinol. | pmid:8701793 |
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Abe M et al. | Evaluation of the effects of steroids on experimental septic lung injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8848431 |
Leier I et al. | ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. | 1996 | Biochem. J. | pmid:8670053 |
Shindo K et al. | Priming effect of platelet activating factor on leukotriene C4 from stimulated eosinophils of asthmatic patients. | 1996 | Thorax | pmid:8711647 |
Itoh K et al. | Relationship between airway eosinophilia and airway hyperresponsiveness in a late asthmatic model of guinea pigs. | 1996 | Int. Arch. Allergy Immunol. | pmid:8527956 |
Wei EQ et al. | Effect of ONO-1078, a leukotriene antagonist, on capsaicin- and substance P-induced bronchoconstriction and airway microvascular leakage in guinea pigs. | 1996 | Zhongguo Yao Li Xue Bao | pmid:9812736 |
Tang DG et al. | Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8643560 |
Matsuo M et al. | Leukotriene B4 and C4 in cerebrospinal fluid from children with meningitis and febrile seizures. | 1996 | Pediatr. Neurol. | pmid:8703223 |
Papayianni A et al. | Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. | 1996 | J. Immunol. | pmid:8690917 |
Batirel HF et al. | The effect of aqueous garlic extract on the levels of arachidonic acid metabolites (leukotriene C4 and prostaglandin E2) in rat forebrain after ischemia-reperfusion injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804127 |
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Richter L et al. | Increased biliary secretion of cysteinyl-leukotrienes in human bile duct obstruction. | 1996 | J. Hepatol. | pmid:8938552 |
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Genovese A et al. | Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human Fc epsilon RI+ cells. | 1997 | Clin. Exp. Allergy | pmid:9179431 |
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Cunningham FM et al. | Pharmacology of the 5-lipoxygenase inhibitors BAY Y 1015 and BAY X 1005 in the horse. | 1997 | J. Vet. Pharmacol. Ther. | pmid:9280370 |
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Keppler D et al. | The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes. | 1997 | Adv. Enzyme Regul. | pmid:9381978 |
Bailey JM et al. | Activation of mitogen-induced T-lymphocyte proliferation by leukotriene C-4. | 1997 | Biochem. Soc. Trans. | pmid:9388724 |
Zweiman B et al. | Nasal airway changes assessed by acoustic rhinometry and mediator release during immediate and late reactions to allergen challenge. | 1997 | J. Allergy Clin. Immunol. | pmid:9389292 |
Bacha EA et al. | Gastric antigen challenge releases gastrin and eicosanoids and protects against ethanol. | 1997 | J. Surg. Res. | pmid:9228931 |
Hamasaki Y et al. | The Chinese herbal medicine, shinpi-to, inhibits IgE-mediated leukotriene synthesis in rat basophilic leukemia-2H3 cells. | 1997 | J Ethnopharmacol | pmid:9174973 |