LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ebihara S et al. | A simple preparation method for mouse eosinophils and their responses to anti-allergic drugs. | 2007 | Inflamm. Res. | pmid:17406808 |
| Liu YG and Luo JB | [Effects of among compositions of Herba Ephedrae decoction on genic xpression of 5-lipoxygenase activating protein, IL-4 and leukotriene C4 in asthmatic mice]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17432150 |
| Zhang XC et al. | Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17483291 |
| Létourneau IJ et al. | Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function. | 2007 | Drug Metab. Dispos. | pmid:17494643 |
| Yang SL et al. | Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. | 2007 | Pharmacology | pmid:17496435 |
| Zhang L et al. | Mechanistic study on the intestinal absorption and disposition of baicalein. | 2007 | Eur J Pharm Sci | pmid:17507208 |
| Jame AJ et al. | Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. | 2007 | Clin. Exp. Allergy | pmid:17517102 |
| Seres I et al. | The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome. | 2006 | J. Membr. Biol. | pmid:17546512 |
| Perrotton T et al. | (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. | 2007 | J. Biol. Chem. | pmid:17646169 |
| Kopp MV et al. | Omalizumab (Xolair) in children with seasonal allergic rhinitis: leukotriene release as a potential in vitro parameter to monitor therapeutic effects. | 2007 | Pediatr Allergy Immunol | pmid:17680911 |
| Farias SE et al. | Transcellular biosynthesis of cysteinyl leukotrienes in rat neuronal and glial cells. | 2007 | J. Neurochem. | pmid:17711426 |
| Laengle UW et al. | Effects of latanoprost, timolol and GLC756, a novel dopamine D(2) agonist and D(1) antagonist on LTC(4) release after rat mast cell activation. | 2007 Sep-Oct | Clin. Experiment. Ophthalmol. | pmid:17894685 |
| Wang W et al. | Mechanistic study of potentiation of chemotherapy by a haloenol lactone derivative in vitro. | 2008 | Cancer Chemother. Pharmacol. | pmid:17899085 |
| Chang WC et al. | All-or-none activation of CRAC channels by agonist elicits graded responses in populations of mast cells. | 2007 | J. Immunol. | pmid:17911611 |
| Hattori Y et al. | Gastric mucosal protection against ethanol by EP2 and EP4 signaling through the inhibition of leukotriene C4 production. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17947453 |
| Rius M et al. | ATP-dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4). | 2008 | J. Pharmacol. Exp. Ther. | pmid:17959747 |
| Yang SH and Yu CL | Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis. | 2008 | J Ethnopharmacol | pmid:17980528 |
| Mustafa FB et al. | Honeybee venom secretory phospholipase A2 induces leukotriene production but not histamine release from human basophils. | 2008 | Clin. Exp. Immunol. | pmid:18005261 |
| Devakumar A et al. | Structural analysis of leukotriene C4 isomers using collisional activation and 157 nm photodissociation. | 2008 | J. Am. Soc. Mass Spectrom. | pmid:18024058 |
| Thompson C et al. | Signaling by the cysteinyl-leukotriene receptor 2. Involvement in chemokine gene transcription. | 2008 | J. Biol. Chem. | pmid:18048362 |
| Slot AJ et al. | Modulation of human multidrug resistance protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) transport activities by endogenous and exogenous glutathione-conjugated catechol metabolites. | 2008 | Drug Metab. Dispos. | pmid:18079363 |
| Chang WC et al. | Local Ca2+ influx through Ca2+ release-activated Ca2+ (CRAC) channels stimulates production of an intracellular messenger and an intercellular pro-inflammatory signal. | 2008 | J. Biol. Chem. | pmid:18156181 |
| Feltenmark S et al. | Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18184802 |
| Wang J et al. | Does leukotriene affect intracellular glutathione redox state in cultured human airway epithelial cells? | 2008 | Antioxid. Redox Signal. | pmid:18199004 |
| Cao F et al. | Mrp2-related efflux of scutellarin in the intestinal absorption in rats. | 2008 | Pharmazie | pmid:18271309 |
| Korzekwa AJ et al. | Luteolytic effect of prostaglandin F 2 alpha on bovine corpus luteum depends on cell composition and contact. | 2008 | Reprod. Domest. Anim. | pmid:18282218 |
| Ito Y et al. | Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. | 2008 | BMB Rep | pmid:18315950 |
| Létourneau IJ et al. | Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter. | 2008 | Biochem. Pharmacol. | pmid:18336795 |
| Heredi-Szabo K et al. | Characterization of 5(6)-carboxy-2,'7'-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4. | 2008 | J Biomol Screen | pmid:18349419 |
| Moon TC et al. | The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2008 | Arch. Pharm. Res. | pmid:18365692 |
| Bandler PE et al. | Identification of regions required for apical membrane localization of human multidrug resistance protein 2. | 2008 | Mol. Pharmacol. | pmid:18381564 |
| Mochizuki Y et al. | Suppressive activity of epinastine hydrochloride on eosinophil activation in vitro. | 2008 Jan-Feb | In Vivo | pmid:18396776 |
| Aleo MD et al. | An underlying role for hepatobiliary dysfunction in cyclosporine A nephrotoxicity. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18407308 |
| Zheng MS et al. | Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity. | 2008 | Arch. Pharm. Res. | pmid:18409044 |
| Bäck M | Cysteinyl-leukotrienes in cerebrovascular disease: angels and demons? | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18421005 |
| Ma KF et al. | Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model. | 2008 | World J. Gastroenterol. | pmid:18461660 |
| Mishra NC et al. | Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens. | 2008 | J. Immunol. | pmid:18490768 |
| Mueller CF et al. | Multidrug resistance protein-1 affects oxidative stress, endothelial dysfunction, and atherogenesis via leukotriene C4 export. | 2008 | Circulation | pmid:18506003 |
| Chaung HC et al. | Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells. | 2009 | Res. Vet. Sci. | pmid:18565553 |
| Marchan R et al. | Multidrug resistance-associated protein 1 as a major mediator of basal and apoptotic glutathione release. | 2008 | Biochim. Biophys. Acta | pmid:18621020 |
| Yang R et al. | Interaction between the bound Mg.ATP and the Walker A serine residue in NBD2 of multidrug resistance-associated protein MRP1 plays a crucial role for the ATP-dependent leukotriene C4 transport. | 2008 | Biochemistry | pmid:18636743 |
| Reichel V et al. | Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus. | 2008 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:18650317 |
| Niwa Y et al. | Opposite effects of PU.1 on mast cell stimulation. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18680724 |
| Kirshenbaum AS et al. | Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition. | 2008 | BMC Immunol. | pmid:18687131 |
| Rothnie A et al. | Mechanistic differences between GSH transport by multidrug resistance protein 1 (MRP1/ABCC1) and GSH modulation of MRP1-mediated transport. | 2008 | Mol. Pharmacol. | pmid:18768387 |
| Grant CE et al. | Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). | 2008 | Drug Metab. Dispos. | pmid:18775981 |
| Tan Y and Lim LH | trans-Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation. | 2008 | Br. J. Pharmacol. | pmid:18776917 |
| Blokzijl H et al. | Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease. | 2008 | J. Biol. Chem. | pmid:18838379 |
| Maekawa A et al. | Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18931305 |
| Pecaric-Petkovic T et al. | Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. | 2009 | Blood | pmid:18955562 |