LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Hypotension D007022 41 associated lipids
Gastritis D005756 27 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Osteosarcoma D012516 50 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Asthma D001249 52 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Ulcer D014456 16 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Peritonitis D010538 38 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Leukemia D007938 74 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Myocardial Ischemia D017202 11 associated lipids
Glomerulonephritis D005921 35 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Nasal Polyps D009298 26 associated lipids
Ear Diseases D004427 7 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Anaphylaxis D000707 35 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Eosinophilia D004802 4 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Status Asthmaticus D013224 4 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Acute-Phase Reaction D000210 12 associated lipids
Uveitis D014605 14 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Yoshisue H et al. Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts. 2007 J. Allergy Clin. Immunol. pmid:17208594
Lee KS et al. Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. 2007 J. Allergy Clin. Immunol. pmid:17208595
Lee TH et al. Leukotriene E4: perspective on the forgotten mediator. 2009 J. Allergy Clin. Immunol. pmid:19482346
Austen KF et al. The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. 2009 J. Allergy Clin. Immunol. pmid:19647860
Chen YH et al. IFN-alpha inhibits IL-3 priming of human basophil cytokine secretion but not leukotriene C4 and histamine release. 2003 J. Allergy Clin. Immunol. pmid:14610485
Triggiani M et al. Lung mast cells are a source of secreted phospholipases A2. 2009 J. Allergy Clin. Immunol. pmid:19541351
Miura K et al. Phosphorylation of cytosolic phospholipase A2 by IL-3 is associated with increased free arachidonic acid generation and leukotriene C4 release in human basophils. 1998 J. Allergy Clin. Immunol. pmid:9768595
Bandeira-Melo C et al. Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. 2002 J. Allergy Clin. Immunol. pmid:12063527
Oskeritzian CA et al. Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell. 2005 J. Allergy Clin. Immunol. pmid:15940129
Lane SJ and Lee TH Mast cell effector mechanisms. 1996 J. Allergy Clin. Immunol. pmid:8939179
Shilling AD et al. Use of canalicular membrane vesicles (CMVs) from rats, dogs, monkeys and humans to assess drug transport across the canalicular membrane. 2006 May-Jun J Pharmacol Toxicol Methods pmid:16176877
Ramis I et al. Application of totally automated on-line sample clean up system for extraction and high-performance liquid chromatography separation of peptide leukotrienes. 1993 Nov-Dec J Pharm Biomed Anal pmid:8123725
Syslová K et al. Immunomagnetic molecular probe with UHPLC-MS/MS: a promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes. 2013 Jul-Aug J Pharm Biomed Anal pmid:23644905
Herron DK et al. Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. 1995 J Mol Graph pmid:8820302
Jakobsson PJ et al. Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer. 1997 J Lipid Mediat Cell Signal pmid:9302651
Lam BK et al. Leukotriene C4 synthase. 1995 J Lipid Mediat Cell Signal pmid:8777577
Liebhart J et al. Production of leukotriene C4 by peripheral blood leukocytes stimulated with anti-fcepsilonRI antibody, PMA, and fMLP does not correlate with irreversible airway obstruction in asthmatics. 2007 J Investig Allergol Clin Immunol pmid:17323856
Annila I et al. Bee venom induces high histamine or high leukotriene C4 release in skin of sensitized beekeepers. 2000 Jul-Aug J Investig Allergol Clin Immunol pmid:11039839
Kimura Y et al. Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. 1995 J Ethnopharmacol pmid:7776662
Abad MJ et al. Anti-inflammatory activity of four Bolivian Baccharis species (Compositae). 2006 J Ethnopharmacol pmid:16202549
Quan Z et al. Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation. 2010 J Ethnopharmacol pmid:20699114
Di Sotto A et al. Pharmacological and phytochemical study on a Sisymbrium officinale Scop. extract. 2010 J Ethnopharmacol pmid:19969059
Yang SH and Yu CL Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis. 2008 J Ethnopharmacol pmid:17980528
Hamasaki Y et al. The Chinese herbal medicine, shinpi-to, inhibits IgE-mediated leukotriene synthesis in rat basophilic leukemia-2H3 cells. 1997 J Ethnopharmacol pmid:9174973
Kjellström S et al. On-line coupling of microdialysis sampling with liquid chromatography for the determination of peptide and non-peptide leukotrienes. 1998 J Chromatogr A pmid:9818423
Al-Amran FG et al. Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats. 2011 J Cardiothorac Surg pmid:21649921
Heredi-Szabo K et al. Characterization of 5(6)-carboxy-2,'7'-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4. 2008 J Biomol Screen pmid:18349419
Mitsunobu F et al. Different roles of histamine and leukotriene C4 in the airways between patients with atopic and nonatopic asthma. 1998 J Asthma pmid:9669831
Xu R et al. Novel polyhydroxylated steroids from the East China Sea gorgonian Echinogorgia sassapo reticulata with suppressive activity of leukotriene C4 generation and degranulation in bone marrow-derived mast cells. 2014 J Asian Nat Prod Res pmid:24437431
Sciuto AM et al. Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. 1998 Sep-Oct J Appl Toxicol pmid:9804432
Okamoto M et al. Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma. 2000 Intern. Med. pmid:10732825
Daugschies A and Ruttkowski B Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. 1998 Int. J. Parasitol. pmid:9513001
Meier HL et al. Simultaneous initiation of degranulation and inhibition of leukotriene release by soman in human basophils. 1995 Int. J. Immunopharmacol. pmid:7545649
Hamasaki Y et al. (9-[4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido [1,2-a] pyrimidin-4-one), AS-35, inhibits leukotriene synthesis. 2000 Int. J. Immunopharmacol. pmid:10785545
Vigorito C et al. Metabolic and hemodynamic effects of peptide leukotriene C4 and D4 in man. 1997 Int. J. Clin. Lab. Res. pmid:9352380
Sharma R et al. RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. 2004 Int. J. Cancer pmid:15386349
Meszaros P et al. Long term myriocin treatment increases MRP1 transport activity. 2013 Int. J. Biochem. Cell Biol. pmid:23178537
Jung HW et al. Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis. 2013 Int. Immunopharmacol. pmid:23643816
Muraki M et al. Inhaled montelukast inhibits cysteinyl-leukotriene-induced bronchoconstriction in ovalbumin-sensitized guinea-pigs: the potential as a new asthma medication. 2009 Int. Immunopharmacol. pmid:19706339
Fujisaki T et al. Bestatin selectively suppresses the growth of leukemic stem/progenitor cells with BCR/ABL mRNA transcript in patients with chronic myelogeneous leukemia. 2003 Int. Immunopharmacol. pmid:12781706
Yang SH et al. The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs. 2002 Int. Immunopharmacol. pmid:12469937
Rossi MI et al. Long-term exacerbation by interleukin 13 of IgE-mediated eosinophilia in rats. 2005 Int. Immunopharmacol. pmid:15953562
Nunomura S et al. Role of the FcepsilonRI beta-chain ITAM as a signal regulator for mast cell activation with monomeric IgE. 2005 Int. Immunol. pmid:15944196
Iwamoto I et al. Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. 1995 Int. Arch. Allergy Immunol. pmid:7647588
Ilarraza R et al. Montelukast inhibits leukotriene stimulation of human dendritic cells in vitro. 2012 Int. Arch. Allergy Immunol. pmid:22846852
Itoh K et al. Relationship between airway eosinophilia and airway hyperresponsiveness in a late asthmatic model of guinea pigs. 1996 Int. Arch. Allergy Immunol. pmid:8527956
Wang D et al. Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure. 1995 Int. Arch. Allergy Immunol. pmid:7888790
Kitahata Y et al. Prolonged culture of mast cells with high-glucose medium enhances the Fc epsilon RI-mediated degranulation response and leukotriene C4 production. 2010 Int. Arch. Allergy Immunol. pmid:20523060
Austen KF The Paul Kallós Memorial Lecture. From slow-reacting substance of anaphylaxis to leukotriene C4 synthase. 1995 May-Jun Int. Arch. Allergy Immunol. pmid:7613129
Okamoto M et al. Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism. 2000 Int. Arch. Allergy Immunol. pmid:10878492