Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Brady HR et al. | Transcellular pathways and cell adhesion as potential contributors to leukotriene and lipoxin biosynthesis in acute glomerulonephritis. | 1997 | Adv. Exp. Med. Biol. | pmid:9547614 |
Bäck M et al. | The contraction of the human pulmonary artery by LTC4 is resistant to cysLT1 antagonists and counteracted by prostacyclin release. | 2002 | Adv. Exp. Med. Biol. | pmid:12664603 |
Kalayci O et al. | LTC4 production by eosinophils in asthmatic subjects with alternative forms of ALOX-5 core promoter. | 2003 | Adv. Exp. Med. Biol. | pmid:12751728 |
Hsueh W et al. | Injurious and protective mechanisms in the gut. Interaction of PAF, phospholipase A2, eicosanoids, and nitric oxide synthase. | 1997 | Adv. Exp. Med. Biol. | pmid:9321977 |
Lieberman MW et al. | Gamma-glutamyl leukotrienase cleavage of leukotriene C4. | 1999 | Adv. Exp. Med. Biol. | pmid:10667345 |
Schweitzer P et al. | Cannabinoid modulation of neuronal activity in adult rat hippocampus. | 1999 | Adv. Exp. Med. Biol. | pmid:10667381 |
Herman CA and Luczy-Bachman G | Eicosanoids in the brain of warm- and cold-acclimated bullfrogs. | 1999 | Adv. Exp. Med. Biol. | pmid:10667397 |
Keppler D et al. | The function of the multidrug resistance proteins (MRP and cMRP) in drug conjugate transport and hepatobiliary excretion. | 1996 | Adv. Enzyme Regul. | pmid:8869738 |
Böhme M et al. | ATP-dependent export pumps and their inhibition by cyclosporins. | 1994 | Adv. Enzyme Regul. | pmid:7942282 |
Keppler D et al. | The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes. | 1997 | Adv. Enzyme Regul. | pmid:9381978 |