LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Hypotension D007022 41 associated lipids
Gastritis D005756 27 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Osteosarcoma D012516 50 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Asthma D001249 52 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Ulcer D014456 16 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Peritonitis D010538 38 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Leukemia D007938 74 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Myocardial Ischemia D017202 11 associated lipids
Glomerulonephritis D005921 35 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Nasal Polyps D009298 26 associated lipids
Ear Diseases D004427 7 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Anaphylaxis D000707 35 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Eosinophilia D004802 4 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Status Asthmaticus D013224 4 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Acute-Phase Reaction D000210 12 associated lipids
Uveitis D014605 14 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Le Poole IC et al. Organotypic culture of human skin to study melanocyte migration. 1994 Pigment Cell Res. pmid:8072944
Takase B et al. Effects of bepridil on silent myocardial ischemia and eicosanoid metabolism in chronic stable angina pectoris after healing of myocardial infarction. 1994 Am. J. Cardiol. pmid:8198031
Munoz NM et al. Beta adrenergic modulation of formyl-methionine-leucine-phenylalanine-stimulated secretion of eosinophil peroxidase and leukotriene C4. 1994 J. Pharmacol. Exp. Ther. pmid:8301549
Sathirakul K et al. Multiple transport systems for organic anions across the bile canalicular membrane. 1994 J. Pharmacol. Exp. Ther. pmid:8301595
Metters KM et al. Microsomal glutathione S-transferase is the predominant leukotriene C4 binding site in cellular membranes. 1994 J. Biol. Chem. pmid:8175695
Tudhope SR et al. BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. 1994 Eur. J. Pharmacol. pmid:7698171
Ducep JB et al. Synthesis of 5- and 6-fluoro derivatives of 5,8,14-eicosatrienoic and 5,8,11,14-eicosatetraenoic acids. Effects of fluorinated arachidonic acids on leukotriene C4 production by macrophages. 1994 Bioorg. Med. Chem. pmid:7922133
Schauer U et al. Blood eosinophils, leukotriene C4 generation, and bronchial hyperreactivity in formerly preterm infants. 1994 Arch. Dis. Child. pmid:7726609
Ibe BO et al. Plasma and urinary leukotrienes in sickle cell disease: possible role in the inflammatory process. 1994 Eur. J. Clin. Invest. pmid:8187808
Kargman S et al. Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells. 1994 Mol. Pharmacol. pmid:8190095
Zuany-Amorim C et al. Strain-dependency of leukotriene C4 generation from isolated lungs of immunized mice. 1994 Br. J. Pharmacol. pmid:7524994
Shimizu T et al. Effects of pancreatic and snake venom phospholipase A2 on the generation of leukotriene B4 and C4 by human leukocytes in vitro. 1994 Pancreas pmid:8108369
Fauler J et al. Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis. 1994 Arthritis Rheum. pmid:8129769
Willburger RE and Wittenberg RH Prostaglandin release from lumbar disc and facet joint tissue. 1994 Spine pmid:7825047
Wang D et al. Concentrations of chemical mediators in nasal secretions of patients with hay fever during natural allergen exposure. 1994 Acta Otolaryngol. pmid:7825440
Goulet JL et al. Altered inflammatory responses in leukotriene-deficient mice. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7809134
Müller M et al. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7809167
HasanoÄŸlu E et al. The role of prostanoids in the complications of extracorporeal shock wave lithotripsy (ESWL) in children. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846111
Hamasaki Y et al. Inhibition by dexamethasone of retinoic acid-induced enhancement of leukotriene C4 synthesis in rat basophilic leukemia-1 cells. 1994 Am. J. Respir. Cell Mol. Biol. pmid:8018338
Liu L et al. Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum. 1994 Arzneimittelforschung pmid:7848335
Schuil PJ et al. Histamine and leukotriene C4 effects on in vitro ciliary beat frequency of human upper respiratory cilia. 1994 Eur Arch Otorhinolaryngol pmid:7848641
Currie S et al. Phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in MCII mast cells mediated by high-affinity Fc receptor for IgE. 1994 Biochem. J. pmid:7818499
Teshigawara H and Moriya Y The role of leukotriene C4 in biphasic release of histamine from mouse mastocytoma cell line (P-815). 1994 Gen. Pharmacol. pmid:7530673
Leff AR Inflammatory mediation of airway hyperresponsiveness by peripheral blood granulocytes. The case for the eosinophil. 1994 Chest pmid:7924496
Büchler M et al. Functional reconstitution of ATP-dependent transporters from the solubilized hepatocyte canalicular membrane. 1994 Eur. J. Biochem. pmid:7925347
Kawashima T et al. Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils. 1994 Int. Arch. Allergy Immunol. pmid:8130655
Raible DG Erythrocytes increase leukotriene C4 release from human eosinophils: characterization and examination of possible mechanisms. 1994 J. Leukoc. Biol. pmid:8027672
Mitsuhashi T et al. Increased production of eicosanoids, TXA2, PGI2 and LTC4 in experimental spinal cord injuries. 1994 Paraplegia pmid:7970857
Volland H et al. Enzyme immunometric assay for leukotriene C4. 1994 J. Immunol. Methods pmid:7930643
Chen CR et al. Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids. 1994 Am. J. Respir. Crit. Care Med. pmid:8111595
Büyükgebiz O et al. Captopril increases endothelin serum concentrations and preserves intestinal mucosa after mesenteric ischemia-reperfusion injury. 1994 Res Exp Med (Berl) pmid:7536337
Petric R and Ford-Hutchinson AW Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. 1994 Kidney Int. pmid:7853790
Leier I et al. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. 1994 J. Biol. Chem. pmid:7961706
Aktan AO et al. Does PGE2 act as a mediator for endothelin release? 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7511821
YeÄŸen C et al. Effect of verapamil and iloprost (ZK 36374) on endothelin release after mesenteric ischemia-reperfusion injury. 1994 Eur Surg Res pmid:7516292
Wettstein M and Häussinger D [Effect of hypoxia on nitric oxide formation and leukotriene metabolism in the perfused rat liver]. 1994 Zentralbl Chir pmid:7517604
Bürgi B et al. The degradation product of the C5a anaphylatoxin C5adesarg retains basophil-activating properties. 1994 Eur. J. Immunol. pmid:7517876
Sainte-Laudy J et al. [Demonstration of sulfite-group-specific IgE in patients with intolerance to preservatives]. 1994 Allerg Immunol (Paris) pmid:7518236
Miadonna A et al. Modulation of allergen-induced nasal symptoms and mediator release by treatment with N-acetyl-aspartyl-glutamate (ZY15106). 1994 Eur. J. Clin. Pharmacol. pmid:7518775
Yamamura H et al. Endothelin-1 induces release of histamine and leukotriene C4 from mouse bone marrow-derived mast cells. 1994 Eur. J. Pharmacol. pmid:7522171
Tsopanoglou NE et al. Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction. 1994 Eur. J. Pharmacol. pmid:7523148
Tedeschi A et al. Nasal eosinophilia induced by PAF-acether is accompanied by the release of eosinophil cationic protein. 1994 Eur. Respir. J. pmid:7525344
Ramachers U et al. Direct effects of second-generation H1-receptor antagonists on the activation of human basophils. 1994 Agents Actions pmid:7526656
Mita H et al. [Release of chemical mediators in the conjunctival lavage fluids after eye provocation with allergen or compound 48/80]. 1994 Arerugi pmid:7526828
Matsumoto T et al. Effects of diet on experimentally induced intestinal ulcers in rats: morphology and tissue leukotrienes. 1994 Gut pmid:7926906
Shimizu T et al. Inhibitory effects of theophylline, terbutaline, and hydrocortisone on leukotriene B4 and C4 generation by human leukocytes in vitro. 1994 Pediatr. Pulmonol. pmid:7800427
Scadding GK et al. Effect of short-term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge. 1994 Br J Clin Pharmacol pmid:7893587
Ishii K et al. A useful method for differential evaluation of anti-inflammatory effects due to cyclooxygenase and 5-lipoxygenase inhibitions in mice. 1994 Jpn. J. Pharmacol. pmid:7990266
Fiore S et al. Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. 1994 J. Exp. Med. pmid:8006586
Casellas F et al. Abnormal leukotriene C4 released by unaffected jejunal mucosa in patients with inactive Crohn's disease. 1994 Gut pmid:8174991
Black KL et al. Enzymatic barrier protects brain capillaries from leukotriene C4. 1994 J. Neurosurg. pmid:7931622
Böhme M et al. ATP-dependent export pumps and their inhibition by cyclosporins. 1994 Adv. Enzyme Regul. pmid:7942282
Kurosawa M et al. Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs. 1994 Clin. Exp. Allergy pmid:7842366
Pintos-Morell G et al. Altered leukotriene generation in leukocytes from cystinotic children. 1994 Pediatr. Res. pmid:7877883
Thioudellet C et al. Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. 1994 Eur. J. Biochem. pmid:7913033
Jedlitschky G et al. ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. 1994 Cancer Res. pmid:7915193
Kapuściński A Leukotriene C4 in the rat brain after resuscitation from clinical death. 1994 Folia Neuropathol pmid:7922113
Ohemeng KA et al. Novel bishydroxamic acids as 5-lipoxygenase inhibitors. 1994 Bioorg. Med. Chem. pmid:7922131
Busse WW and Sedgwick JB Eosinophil eicosanoid relations in allergic inflammation of the airways. 1994 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7771338
Gardiner PJ et al. Leukotriene receptors and their selective antagonists. 1994 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7771349
Keppler D et al. Transport and metabolism of leukotrienes. 1994 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7771352
Christie PE et al. Increased urinary LTE4 excretion following inhalation of LTC4 and LTE4 in asthmatic subjects. 1994 Eur. Respir. J. pmid:8050548
Laviolette M et al. Effects of inhaled steroids on blood eosinophils in moderate asthma. 1994 Ann. N. Y. Acad. Sci. pmid:8031001
Cotti E and Torabinejad M Detection of leukotriene C4 in human periradicular lesions. 1994 Int Endod J pmid:8034369
Lam BK et al. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8052639
Yamada N et al. Pharmacological profile of the novel, potent and selective peptide leukotriene antagonist (E)-2,2-diethyl-3'-[2-[2-(4-isopropyl)thiazolyl]ethenyl]succinanilic acid. 1994 Arzneimittelforschung pmid:8053974
Bando T et al. Inhibitory effect of aerosol administration of a sulfidopeptide leukotriene antagonist on bronchoconstriction induced by antigen inhalation in guinea pigs. 1994 Arzneimittelforschung pmid:8053975
Nagashima T et al. The effect of leukotriene C4 on the permeability of brain capillary endothelial cell monolayer. 1994 Acta Neurochir Suppl (Wien) pmid:7976646
Amon U et al. Control function of protein kinase C isozymes on leukotriene generation from human basophils? 1994 Agents Actions pmid:7976816
Medina L et al. Leukotriene C4 upregulates collagenase expression and synthesis in human lung fibroblasts. 1994 Biochim. Biophys. Acta pmid:7981229
Votta BJ and Bertolini DR Cytokine suppressive anti-inflammatory compounds inhibit bone resorption in vitro. 1994 Sep-Oct Bone pmid:7980964
Murakami M et al. The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. 1995 J. Exp. Med. pmid:7540649
Laviolette M et al. Blood eosinophil leukotriene C4 production in asthma of different severities. 1995 Eur. Respir. J. pmid:8575570
Schäfer S and Walland A Staurosporine inhibits the effects of leukotrienes C4 and D4 in isolated guinea pig heart and trachea. 1995 Methods Find Exp Clin Pharmacol pmid:8577209
Shimizu T et al. Leukotriene B4 and C4 metabolism in small intestine mucosa of children with celiac disease. 1995 J. Pediatr. Gastroenterol. Nutr. pmid:8583294
Wang H et al. Regulation of anti-SRBC antibody production by opioids and their mechanisms. 1995 Chin. Med. Sci. J. pmid:8580479
Sato H et al. Biological characteristics of chronic eosinophilic leukemia cells with a t(2;5)(p23;q35) translocation. 1995 Leuk. Lymphoma pmid:8590853
Lam BK et al. Leukotriene C4 synthase. 1995 J Lipid Mediat Cell Signal pmid:8777577
Kawana S and Nishiyama S Pustular psoriasis and aseptic purulent arthritis: possible role of leukotrienes B4 and C4 in a flare of synovitis. 1995 Dermatology (Basel) pmid:7894093
Wang D et al. Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure. 1995 Int. Arch. Allergy Immunol. pmid:7888790
Egger D et al. IL-4 renders mast cells functionally responsive to endothelin-1. 1995 J. Immunol. pmid:7530742
Patella V et al. The antineoplastic bryostatins affect human basophils and mast cells differently. 1995 Blood pmid:7532037
Weber M et al. Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3. 1995 J. Immunol. pmid:7535823
Sjölinder M et al. Phorbol ester-induced suppression of leukotriene C4 synthase activity in human granulocytes. 1995 FEBS Lett. pmid:8543026
Miyamasu M et al. Chemotactic agonists induce cytokine generation in eosinophils. 1995 J. Immunol. pmid:7529800
Horikawa T et al. Melanocyte mitogens induce both melanocyte chemokinesis and chemotaxis. 1995 J. Invest. Dermatol. pmid:7530272
Murakami M et al. Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. 1995 J. Biol. Chem. pmid:7559381
Kurokawa H et al. Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance. 1995 Biochem. Biophys. Res. Commun. pmid:7488097
Sun J and Herman CA The American bullfrog (Rana catesbeiana) exhibits differential cardiovascular responses to LTC4 after short- and long-term cold exposure. 1995 Gen. Comp. Endocrinol. pmid:7622015
Shindo K et al. In vivo effect of prednisolone on release of leukotriene C4 in eosinophils obtained from asthmatic patients. 1995 Biochem. Biophys. Res. Commun. pmid:7575557
Sampson AP et al. Persistent increase in plasma and urinary leukotrienes after acute asthma. 1995 Arch. Dis. Child. pmid:7492159
Zuberbier T et al. Gangliosides enhance IgE receptor-dependent histamine and LTC4 release from human mast cells. 1995 Biochim. Biophys. Acta pmid:7578275
Restrick LJ et al. Reduction in leukotriene B4 generation by bronchoalveolar lavage cells in asthma. 1995 Thorax pmid:7886653
Takagi S et al. The pathophysiological roles of heterogeneous eosinophils in allergic rhinitis caused by house dust mites. 1995 Biochem. Mol. Biol. Int. pmid:7581000
Enderle GJ et al. Different pathomechanisms of altered biliary leukotriene C4 elimination in isolated perfused rat livers. 1995 Biochem. Pharmacol. pmid:7857316
Herron DK et al. Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. 1995 J Mol Graph pmid:8820302
Ganbo T et al. The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. 1995 Rhinology pmid:8919211
Karmeli F et al. A stable nitroxide radical effectively decreases mucosal damage in experimental colitis. 1995 Gut pmid:7590435
Utoh J et al. Is an increase in neutrophil leukotriene-generating capacity a specific phenomenon for cardiopulmonary bypass? 1995 J. Thorac. Cardiovasc. Surg. pmid:7609558
Janssen-Timmen U et al. Expression of 5-lipoxygenase in differentiating human skin keratinocytes. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7624354