Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Miadonna A et al. | Modulation of allergen-induced nasal symptoms and mediator release by treatment with N-acetyl-aspartyl-glutamate (ZY15106). | 1994 | Eur. J. Clin. Pharmacol. | pmid:7518775 |
Yamamura H et al. | Endothelin-1 induces release of histamine and leukotriene C4 from mouse bone marrow-derived mast cells. | 1994 | Eur. J. Pharmacol. | pmid:7522171 |
Tsopanoglou NE et al. | Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction. | 1994 | Eur. J. Pharmacol. | pmid:7523148 |
Tedeschi A et al. | Nasal eosinophilia induced by PAF-acether is accompanied by the release of eosinophil cationic protein. | 1994 | Eur. Respir. J. | pmid:7525344 |
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Matsumoto T et al. | Effects of diet on experimentally induced intestinal ulcers in rats: morphology and tissue leukotrienes. | 1994 | Gut | pmid:7926906 |
Shimizu T et al. | Inhibitory effects of theophylline, terbutaline, and hydrocortisone on leukotriene B4 and C4 generation by human leukocytes in vitro. | 1994 | Pediatr. Pulmonol. | pmid:7800427 |
Scadding GK et al. | Effect of short-term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge. | 1994 | Br J Clin Pharmacol | pmid:7893587 |
Ishii K et al. | A useful method for differential evaluation of anti-inflammatory effects due to cyclooxygenase and 5-lipoxygenase inhibitions in mice. | 1994 | Jpn. J. Pharmacol. | pmid:7990266 |
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Casellas F et al. | Abnormal leukotriene C4 released by unaffected jejunal mucosa in patients with inactive Crohn's disease. | 1994 | Gut | pmid:8174991 |
Black KL et al. | Enzymatic barrier protects brain capillaries from leukotriene C4. | 1994 | J. Neurosurg. | pmid:7931622 |
Böhme M et al. | ATP-dependent export pumps and their inhibition by cyclosporins. | 1994 | Adv. Enzyme Regul. | pmid:7942282 |
Kurosawa M et al. | Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs. | 1994 | Clin. Exp. Allergy | pmid:7842366 |
Pintos-Morell G et al. | Altered leukotriene generation in leukocytes from cystinotic children. | 1994 | Pediatr. Res. | pmid:7877883 |
Thioudellet C et al. | Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. | 1994 | Eur. J. Biochem. | pmid:7913033 |
Jedlitschky G et al. | ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. | 1994 | Cancer Res. | pmid:7915193 |
Kapuściński A | Leukotriene C4 in the rat brain after resuscitation from clinical death. | 1994 | Folia Neuropathol | pmid:7922113 |
Ohemeng KA et al. | Novel bishydroxamic acids as 5-lipoxygenase inhibitors. | 1994 | Bioorg. Med. Chem. | pmid:7922131 |
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Keppler D et al. | Transport and metabolism of leukotrienes. | 1994 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7771352 |
Christie PE et al. | Increased urinary LTE4 excretion following inhalation of LTC4 and LTE4 in asthmatic subjects. | 1994 | Eur. Respir. J. | pmid:8050548 |
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Nagashima T et al. | The effect of leukotriene C4 on the permeability of brain capillary endothelial cell monolayer. | 1994 | Acta Neurochir Suppl (Wien) | pmid:7976646 |
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Schäfer S and Walland A | Staurosporine inhibits the effects of leukotrienes C4 and D4 in isolated guinea pig heart and trachea. | 1995 | Methods Find Exp Clin Pharmacol | pmid:8577209 |
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Patella V et al. | The antineoplastic bryostatins affect human basophils and mast cells differently. | 1995 | Blood | pmid:7532037 |
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Sjölinder M et al. | Phorbol ester-induced suppression of leukotriene C4 synthase activity in human granulocytes. | 1995 | FEBS Lett. | pmid:8543026 |
Miyamasu M et al. | Chemotactic agonists induce cytokine generation in eosinophils. | 1995 | J. Immunol. | pmid:7529800 |
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Murakami M et al. | Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. | 1995 | J. Biol. Chem. | pmid:7559381 |
Kurokawa H et al. | Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488097 |
Sun J and Herman CA | The American bullfrog (Rana catesbeiana) exhibits differential cardiovascular responses to LTC4 after short- and long-term cold exposure. | 1995 | Gen. Comp. Endocrinol. | pmid:7622015 |
Shindo K et al. | In vivo effect of prednisolone on release of leukotriene C4 in eosinophils obtained from asthmatic patients. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575557 |
Sampson AP et al. | Persistent increase in plasma and urinary leukotrienes after acute asthma. | 1995 | Arch. Dis. Child. | pmid:7492159 |
Zuberbier T et al. | Gangliosides enhance IgE receptor-dependent histamine and LTC4 release from human mast cells. | 1995 | Biochim. Biophys. Acta | pmid:7578275 |
Restrick LJ et al. | Reduction in leukotriene B4 generation by bronchoalveolar lavage cells in asthma. | 1995 | Thorax | pmid:7886653 |
Takagi S et al. | The pathophysiological roles of heterogeneous eosinophils in allergic rhinitis caused by house dust mites. | 1995 | Biochem. Mol. Biol. Int. | pmid:7581000 |
Enderle GJ et al. | Different pathomechanisms of altered biliary leukotriene C4 elimination in isolated perfused rat livers. | 1995 | Biochem. Pharmacol. | pmid:7857316 |
Herron DK et al. | Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. | 1995 | J Mol Graph | pmid:8820302 |
Ganbo T et al. | The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. | 1995 | Rhinology | pmid:8919211 |
Karmeli F et al. | A stable nitroxide radical effectively decreases mucosal damage in experimental colitis. | 1995 | Gut | pmid:7590435 |
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