Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Fugazzola M et al. | Non-genomic action of beclomethasone dipropionate on bronchoconstriction caused by leukotriene C4 in precision cut lung slices in the horse. | 2012 | BMC Vet. Res. | pmid:22963524 |
Hong F and Yang S | Ischemic preconditioning decreased leukotriene C4 formation by depressing leukotriene C4 synthase expression and activity during hepatic I/R injury in rats. | 2012 | J. Surg. Res. | pmid:22921920 |
Liu W et al. | Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22982073 |
Lu Y et al. | Saucerneol D inhibits eicosanoid generation and degranulation through suppression of Syk kinase in mast cells. | 2012 | Food Chem. Toxicol. | pmid:22982805 |
Rinaldo-Matthis A et al. | Pre-steady-state kinetic characterization of thiolate anion formation in human leukotriene Câ‚„ synthase. | 2012 | Biochemistry | pmid:22217203 |
Ng SW et al. | Cysteinyl leukotriene type I receptor desensitization sustains Ca2+-dependent gene expression. | 2012 | Nature | pmid:22230957 |
Iram SH and Cole SP | Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1). | 2012 | J. Biol. Chem. | pmid:22232552 |
Han YS et al. | Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells. | 2012 | Inflammation | pmid:22729280 |
Sodani K et al. | Multidrug resistance associated proteins in multidrug resistance. | 2012 | Chin J Cancer | pmid:22098952 |
Jiang W et al. | UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP. | 2012 | Drug Metab. Dispos. | pmid:22071170 |