LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Campbell JD et al. | Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1). | 2004 | J. Biol. Chem. | pmid:14561746 |
| Zhao Q and Chang XB | Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein 1. | 2004 | J. Biol. Chem. | pmid:15355964 |
| Furumoto Y et al. | The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production. | 2004 | J. Biol. Chem. | pmid:15355979 |
| Morii E and Oboki K | MITF is necessary for generation of prostaglandin D2 in mouse mast cells. | 2004 | J. Biol. Chem. | pmid:15375155 |
| Ito R et al. | [Effect of pranlukast on histamine release and leukotriene c4 (ltc4) generation from human peripheral basophils]. | 2004 | Arerugi | pmid:14762327 |
| Hui Y et al. | Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure. | 2004 | Circulation | pmid:15545522 |
| Lam BK | Leukotriene C(4) synthase. | 2003 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12895593 |
| Bandeira-Melo C and Weller PF | Eosinophils and cysteinyl leukotrienes. | 2003 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12895596 |
| Genovese A et al. | Protein Fv produced during viral hepatitis is an endogenous immunoglobulin superantigen activating human heart mast cells. | 2003 | Int. Arch. Allergy Immunol. | pmid:14707465 |
| Vargaftig BB and Singer M | Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12794006 |
| Chen YH et al. | IFN-alpha inhibits IL-3 priming of human basophil cytokine secretion but not leukotriene C4 and histamine release. | 2003 | J. Allergy Clin. Immunol. | pmid:14610485 |
| Liu S et al. | Neuroimmune interactions in guinea pig stomach and small intestine. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12388180 |
| Shimizu T et al. | Effects of n-3 polyunsaturated fatty acids on indomethacin-induced changes in eicosanoid production and blood flow in the gastric mucosa of rats. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878448 |
| Oleschuk CJ et al. | Substitution of Trp1242 of TM17 alters substrate specificity of human multidrug resistance protein 3. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12388190 |
| Keitel V et al. | A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2). | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12388192 |
| Schuhmann MU et al. | Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury. | 2003 | Neurol. Res. | pmid:12866196 |
| Skarzynski DJ et al. | Roles of tumor necrosis factor-alpha of the estrous cycle in cattle: an in vivo study. | 2003 | Biol. Reprod. | pmid:12904309 |
| Arumugam TV et al. | Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. | 2003 | Br. J. Pharmacol. | pmid:12967936 |
| Zhang DW et al. | Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state. | 2003 | J. Biol. Chem. | pmid:12954620 |
| Kowalski ML et al. | Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. | 2003 | J. Allergy Clin. Immunol. | pmid:13679808 |
| Godinot N et al. | Cloning and functional characterization of the multidrug resistance-associated protein (MRP1/ABCC1) from the cynomolgus monkey. | 2003 | Mol. Cancer Ther. | pmid:12657726 |
| Soberman RJ and Christmas P | The organization and consequences of eicosanoid signaling. | 2003 | J. Clin. Invest. | pmid:12697726 |
| Reddanna P et al. | Carboxypeptidase A-catalyzed direct conversion of leukotriene C4 to leukotriene F4. | 2003 | Arch. Biochem. Biophys. | pmid:12729612 |
| Konno T et al. | Identification of domains participating in the substrate specificity and subcellular localization of the multidrug resistance proteins MRP1 and MRP2. | 2003 | J. Biol. Chem. | pmid:12682044 |
| Chibana K et al. | Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin. | 2003 | J. Immunol. | pmid:12682264 |
| Leslie EM et al. | Functional and structural consequences of cysteine substitutions in the NH2 proximal region of the human multidrug resistance protein 1 (MRP1/ABCC1). | 2003 | Biochemistry | pmid:12731862 |
| Kalayci O et al. | LTC4 production by eosinophils in asthmatic subjects with alternative forms of ALOX-5 core promoter. | 2003 | Adv. Exp. Med. Biol. | pmid:12751728 |
| Serio KJ et al. | Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1. | 2003 | J. Immunol. | pmid:12574384 |
| Wang DY et al. | The upper and lower airway responses to nasal challenge with house-dust mite Blomia tropicalis. | 2003 | Allergy | pmid:12580812 |
| Bellou A et al. | Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock. | 2003 | Shock | pmid:12558148 |
| Chen ZS et al. | Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). | 2003 | Mol. Pharmacol. | pmid:12527806 |
| Tedla N et al. | Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12529506 |
| Liu P et al. | Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12531730 |
| Venkatachalam TK et al. | Inhibition of mast cell leukotriene release by thiourea derivatives. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12565956 |
| Kwak WJ et al. | Papyriflavonol A from Broussonetia papyrifera inhibits the passive cutaneous anaphylaxis reaction and has a secretory phospholipase A2-inhibitory activity. | 2003 | Biol. Pharm. Bull. | pmid:12612436 |
| Plath KE et al. | Calcineurin antagonists differentially affect mediator secretion, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases from immunologically activated human basophils. | 2003 | Clin. Exp. Allergy | pmid:12614449 |
| Venkatachalam TK et al. | Substituted heterocyclic thiourea compounds as a new class of anti-allergic agents inhibiting IgE/Fc epsilon RI receptor mediated mast cell leukotriene release. | 2003 | Bioorg. Med. Chem. | pmid:12614897 |
| Meliton AY et al. | Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils. | 2003 | J. Allergy Clin. Immunol. | pmid:12897749 |
| Chen X et al. | [Preventive effects of montelukast on hypoxic pulmonary hypertension in rats]. | 2003 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:12910720 |
| Lie WJ et al. | Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. | 2003 | Clin. Exp. Allergy | pmid:12911788 |
| Moloney ED et al. | Release of inflammatory mediators from eosinophils following a hyperosmolar stimulus. | 2003 | Respir Med | pmid:12924520 |
| Zhang DW et al. | Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3. | 2003 | Biochemistry | pmid:12924948 |
| Payen LF et al. | Role of carboxylate residues adjacent to the conserved core Walker B motifs in the catalytic cycle of multidrug resistance protein 1 (ABCC1). | 2003 | J. Biol. Chem. | pmid:12882957 |
| Nunoya K et al. | Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1). | 2003 | Drug Metab. Dispos. | pmid:12867490 |
| Tanaka H et al. | Biliary excretion of phenolphthalein sulfate in rats. | 2003 | Pharmacology | pmid:12837971 |
| Ichiyama T et al. | Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells. | 2003 | Clin. Exp. Allergy | pmid:12801316 |
| Mizutani N | [Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms]. | 2003 | Yakugaku Zasshi | pmid:12607939 |
| Mechiche H et al. | Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites. | 2003 | Clin. Exp. Allergy | pmid:12859443 |
| Nagase T et al. | A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12505870 |
| Vargaftig BB and Singer M | Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12388339 |