| MeSH term | MeSH ID | Detail |
|---|---|---|
| Insect Bites and Stings | D007299 | 4 associated lipids |
| Status Asthmaticus | D013224 | 4 associated lipids |
| Wounds, Nonpenetrating | D014949 | 4 associated lipids |
| Periapical Periodontitis | D010485 | 6 associated lipids |
| Rhinitis, Allergic, Perennial | D012221 | 6 associated lipids |
| Pneumococcal Infections | D011008 | 7 associated lipids |
| Cholestasis, Extrahepatic | D001651 | 7 associated lipids |
| Ear Diseases | D004427 | 7 associated lipids |
| Rhinitis, Allergic, Seasonal | D006255 | 7 associated lipids |
| Carotid Artery Injuries | D020212 | 8 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chrubasik S et al. | Harpagophytum extracts. | 2002 | Clin. Pharmacol. Ther. | pmid:11823764 |
| Bermejo BP et al. | Sesquiterpenes from Jasonia glutinosa: in vitro anti-inflammatory activity. | 2002 | Biol. Pharm. Bull. | pmid:11824534 |
| Shon YH et al. | Effect of Astragali radix extract on lipopolysaccharide-induced inflammation in human amnion. | 2002 | Biol. Pharm. Bull. | pmid:11824562 |
| Bäck M et al. | Modulation of vascular tone and reactivity by nitric oxide in porcine pulmonary arteries and veins. | 2002 | Acta Physiol. Scand. | pmid:11851592 |
| Küsters S et al. | Effects of antihistamines on leukotriene and cytokine release from dispersed nasal polyp cells. | 2002 | Arzneimittelforschung | pmid:11878205 |
| Iliás A et al. | Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). | 2002 | J. Biol. Chem. | pmid:11880368 |
| Oliveira SH et al. | Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis. | 2002 | Blood | pmid:12453875 |
| Suzuki R and Freed AN | Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11779726 |
| Ohashi M et al. | Effects of phalloidin on the biliary excretion of cholephilic compounds in rats. | 2002 | Pharmacology | pmid:12169763 |
| Arango P and Kountakis SE | Presence of cysteinyl leukotrienes in asthmatic patients with chronic sinusitis. | 2002 | Laryngoscope | pmid:12169896 |
| Gibbs BF et al. | Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization. | 2002 | J. Leukoc. Biol. | pmid:12149431 |
| Hashizume K and Black KL | Increased endothelial vesicular transport correlates with increased blood-tumor barrier permeability induced by bradykinin and leukotriene C4. | 2002 | J. Neuropathol. Exp. Neurol. | pmid:12152787 |
| Haimeur A et al. | Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity. | 2002 | J. Biol. Chem. | pmid:12186871 |
| Norman BH et al. | Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1). | 2002 | Bioorg. Med. Chem. Lett. | pmid:11958985 |
| Kolaczkowska E et al. | Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes. | 2002 | Inflammation | pmid:11989789 |
| Ravasi S et al. | Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. | 2002 | Biochem. Pharmacol. | pmid:11996896 |
| Bandeira-Melo C et al. | IL-16 promotes leukotriene C(4) and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling. | 2002 | J. Immunol. | pmid:11971026 |
| Hashimoto K et al. | Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome. | 2002 | Hepatology | pmid:12395335 |
| Walch L et al. | Pharmacological evidence for a novel cysteinyl-leukotriene receptor subtype in human pulmonary artery smooth muscle. | 2002 | Br. J. Pharmacol. | pmid:12466244 |
| Yang SH et al. | The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs. | 2002 | Int. Immunopharmacol. | pmid:12469937 |
| Neu IS et al. | Leukotrienes in patients with clinically active multiple sclerosis. | 2002 | Acta Neurol. Scand. | pmid:11903112 |
| Ren XQ et al. | A positively charged amino acid proximal to the C-terminus of TM17 of MRP1 is indispensable for GSH-dependent binding of substrates and for transport of LTC4. | 2002 | Biochemistry | pmid:12450376 |
| Ma L et al. | Identification and characterization of the canine multidrug resistance-associated protein. | 2002 | Mol. Cancer Ther. | pmid:12516967 |
| Wiklund CU et al. | Interactions of volatile anesthetics with cholinergic, tachykinin, and leukotriene mechanisms in isolated Guinea pig bronchial smooth muscle. | 2002 | Anesth. Analg. | pmid:12456432 |
| Tsuruoka S et al. | Functional analysis of ABCA8, a new drug transporter. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12379217 |
| Sakata K and Bäck M | Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma. | 2002 | Eur. J. Pharmacol. | pmid:11834255 |
| Bandeira-Melo C et al. | Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. | 2002 | J. Allergy Clin. Immunol. | pmid:12063527 |
| Uemura M et al. | Cysteinyl leukotrienes in the bile of patients with obstructive jaundice. | 2002 | J. Gastroenterol. | pmid:12424566 |
| Evans JF | Cysteinyl leukotriene receptors. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432945 |
| ten Hove T et al. | Differential susceptibility of multidrug resistance protein-1 deficient mice to DSS and TNBS-induced colitis. | 2002 | Dig. Dis. Sci. | pmid:12353855 |
| Malaviya R and Uckun FM | Leflunomide metabolite analogue alpha-cyano-beta-hydroxy-beta-methyl-N-[3-(trifluoromethyl)phenyl]propenamide inhibits IgE/FcepsilonRI receptor-mediated mast cell leukotriene release and allergic asthma in mice. | 2001 Sep-Oct | Am J Ther | pmid:11550070 |
| King BO et al. | Tirofiban administration attenuates platelet and platelet-neutrophil conjugation but not neutrophil degranulation during in vitro VAD circulation. | 2001 May-Jun | ASAIO J. | pmid:11374774 |
| Karaman O et al. | The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis. | 2001 Mar-Apr | Allergol Immunopathol (Madr) | pmid:11420028 |
| Abeywardena MY et al. | Dietary n-3 and n-6 polyunsaturated oils and airway contractility. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418024 |
| Miura K et al. | Localizing a control region in the pathway to leukotriene C(4) secretion following stimulation of human basophils with anti-IgE antibody. | 2001 | J. Immunol. | pmid:11739523 |
| Wang J et al. | [The effects of resuscitation with hypertonic saline solution on the postburn pulmonary injury in scalded dogs]. | 2001 | Zhonghua Shao Shang Za Zhi | pmid:11774813 |
| Eppihimer MJ and Schaub RG | Soluble P-selectin antagonist mediates rolling velocity and adhesion of leukocytes in acutely inflamed venules. | 2001 | Microcirculation | pmid:11296849 |
| DÃaz Lanza AM et al. | Lignan and phenylpropanoid glycosides from Phillyrea latifolia and their in vitro anti-inflammatory activity. | 2001 | Planta Med. | pmid:11345691 |
| de las Heras B et al. | Effects of six diterpenes on macrophage eicosanoid biosynthesis. | 2001 | Life Sci. | pmid:12005260 |
| Vicente AM et al. | Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages. | 2001 | Br. J. Pharmacol. | pmid:11454666 |
| Aoki M et al. | Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11504812 |
| Bäck M et al. | An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea. | 2001 | Br. J. Pharmacol. | pmid:11487525 |
| Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |
| Setoguchi H et al. | Leukotriene C(4) enhances the contraction of porcine tracheal smooth muscle through the activation of Y-27632, a rho kinase inhibitor, sensitive pathway. | 2001 | Br. J. Pharmacol. | pmid:11156567 |
| Amann R et al. | Effects of COX-1 and COX-2 inhibitors on eicosanoid biosynthesis and the release of substance P from the guinea-pig isolated perfused lung. | 2001 | Inflamm. Res. | pmid:11235022 |
| Gronert K et al. | Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. | 2001 | Am. J. Pathol. | pmid:11141472 |
| Picado C and Valero A | COX-1 sparing drugs in aspirin-sensitive asthma. | 2001 | Clin. Exp. Allergy | pmid:11251618 |
| Terlouw SA et al. | Role of multidrug resistance protein 2 (MRP2) in glutathione-bimane efflux from Caco-2 and rat renal proximal tubule cells. | 2001 | Br. J. Pharmacol. | pmid:11682439 |
| Schroeder JT et al. | Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. | 2001 | Clin. Exp. Allergy | pmid:11591186 |
| Hui Y et al. | The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. | 2001 | J. Biol. Chem. | pmid:11591709 |