| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mesenteric Vascular Occlusion | D008641 | 4 associated lipids |
| Eosinophilia | D004802 | 4 associated lipids |
| Insect Bites and Stings | D007299 | 4 associated lipids |
| Periapical Periodontitis | D010485 | 6 associated lipids |
| Rhinitis, Allergic, Perennial | D012221 | 6 associated lipids |
| Ear Diseases | D004427 | 7 associated lipids |
| Rhinitis, Allergic, Seasonal | D006255 | 7 associated lipids |
| Pneumococcal Infections | D011008 | 7 associated lipids |
| Cholestasis, Extrahepatic | D001651 | 7 associated lipids |
| Carotid Artery Injuries | D020212 | 8 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Enomoto F et al. | [Evaluation of arachidonic acid metabolites in experimental rat otitis media with effusion]. | 1995 | Nippon Jibiinkoka Gakkai Kaiho | pmid:7629649 |
| Murakami M et al. | The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. | 1995 | J. Exp. Med. | pmid:7540649 |
| Gimpel JA et al. | Reduction of reperfusion injury of human myocardium by allopurinol: a clinical study. | 1995 | Free Radic. Biol. Med. | pmid:7649495 |
| Wettstein M et al. | Metabolism of cysteinyl leukotrienes in the perfused rat liver: the influence of endotoxin pretreatment and the cellular hydration state. | 1995 | Hepatology | pmid:7601416 |
| Meier HL et al. | Simultaneous initiation of degranulation and inhibition of leukotriene release by soman in human basophils. | 1995 | Int. J. Immunopharmacol. | pmid:7545649 |
| Porreca E et al. | Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. | 1995 | Atherosclerosis | pmid:7755646 |
| Lam BK et al. | Expression cloning of human LTC4 synthase. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732869 |
| Cruz JR et al. | Fecal excretion of leukotriene C4 during human disease due to Shigella dysenteriae. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7714683 |
| Nishikawa M et al. | Effect of leukotriene C4D4 antagonist on colonic damage induced by intracolonic administration of trinitrobenzene sulfonic acid in rats. | 1995 | J. Gastroenterol. | pmid:7719412 |
| Kita H et al. | Eosinophil major basic protein induces degranulation and IL-8 production by human eosinophils. | 1995 | J. Immunol. | pmid:7722326 |
| Iwamoto I et al. | Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. | 1995 | Int. Arch. Allergy Immunol. | pmid:7647588 |
| Sun J and Herman CA | Cardiovascular effects of N-methyl leukotriene C4, a nonmetabolizable leukotriene C4 analogue, and the antagonism of leukotriene-induced hypotension by Ro 23-3544, in the American bullfrog, Rana catesbeiana. | 1995 | Can. J. Physiol. Pharmacol. | pmid:7648518 |
| Laviolette M et al. | Blood eosinophil leukotriene C4 production in asthma of different severities. | 1995 | Eur. Respir. J. | pmid:8575570 |
| Hong JT et al. | Effect of phenobarbital and the peroxisome proliferator ciprofibrate on gamma-Glutamyltranspeptidase activity and leukotriene C4 concentration in cultured rat hepatocytes. | 1995 | J. Biochem. Toxicol. | pmid:8847705 |
| Schäfer S and Walland A | Staurosporine inhibits the effects of leukotrienes C4 and D4 in isolated guinea pig heart and trachea. | 1995 | Methods Find Exp Clin Pharmacol | pmid:8577209 |
| Shimizu T et al. | Leukotriene B4 and C4 metabolism in small intestine mucosa of children with celiac disease. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:8583294 |
| Wang H et al. | Regulation of anti-SRBC antibody production by opioids and their mechanisms. | 1995 | Chin. Med. Sci. J. | pmid:8580479 |
| Sato H et al. | Biological characteristics of chronic eosinophilic leukemia cells with a t(2;5)(p23;q35) translocation. | 1995 | Leuk. Lymphoma | pmid:8590853 |
| Lam BK et al. | Leukotriene C4 synthase. | 1995 | J Lipid Mediat Cell Signal | pmid:8777577 |
| Ju HR et al. | Systemic release of mucosal mast-cell protease in primed brown Norway rats after feeding with beta-lactoglobulin. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7787291 |
| RodrÃguez-Ortigosa CM et al. | Taurocholate-stimulated leukotriene C4 biosynthesis and leukotriene C4-stimulated choleresis in isolated rat liver. | 1995 | Gastroenterology | pmid:7768385 |
| Tschugguel W et al. | High precision measurement of electrical resistance across endothelial cell monolayers. | 1995 | Pflugers Arch. | pmid:7667075 |
| Miadonna A et al. | Antiallergic activity of loratadine: inhibition of leukotriene C4 release from human leucocytes. | 1995 | Clin. Exp. Allergy | pmid:7541309 |
| Kristjánsson S et al. | Leukotriene B4 and C4 generation by human leukocytes after ex vivo stimulation with Ca-ionophore and opsonized zymosan in children with atopic asthma. | 1995 | Pediatr Allergy Immunol | pmid:8750311 |
| Tornhamre S et al. | Receptor-mediated regulation of leukotriene C4 synthase activity in human platelets. | 1995 | Eur. J. Biochem. | pmid:8536697 |
| Van Dijk JP et al. | Nicotine inhibits cytokine synthesis by mouse colonic mucosa. | 1995 | Eur. J. Pharmacol. | pmid:7664807 |
| Brandenburg K et al. | Conformation and fluidity of endotoxins as determinants of biological activity. | 1995 | Prog. Clin. Biol. Res. | pmid:8524923 |
| Fiore S and Serhan CN | Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction. | 1995 | Biochemistry | pmid:8527441 |
| Wang D et al. | Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888790 |
| Egger D et al. | IL-4 renders mast cells functionally responsive to endothelin-1. | 1995 | J. Immunol. | pmid:7530742 |
| Patella V et al. | The antineoplastic bryostatins affect human basophils and mast cells differently. | 1995 | Blood | pmid:7532037 |
| Weber M et al. | Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3. | 1995 | J. Immunol. | pmid:7535823 |
| Romanelli F et al. | Arachidonic acid and its metabolites effects on testosterone production by rat Leydig cells. | 1995 | J. Endocrinol. Invest. | pmid:7615904 |
| Patella V et al. | Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. | 1995 | J. Immunol. | pmid:7533185 |
| Grønbech JE and Lacy ER | Role of gastric blood flow in impaired defense and repair of aged rat stomachs. | 1995 | Am. J. Physiol. | pmid:7491966 |
| Ochensberger B et al. | IgE-independent interleukin-4 expression and induction of a late phase of leukotriene C4 formation in human blood basophils. | 1995 | Blood | pmid:7492759 |
| Culo F et al. | Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice. | 1995 | Eur J Gastroenterol Hepatol | pmid:7496865 |
| Sjölinder M et al. | Phorbol ester-induced suppression of leukotriene C4 synthase activity in human granulocytes. | 1995 | FEBS Lett. | pmid:8543026 |
| Miyamasu M et al. | Chemotactic agonists induce cytokine generation in eosinophils. | 1995 | J. Immunol. | pmid:7529800 |
| Rachmilewitz D et al. | Sulfhydryl blocker-induced rat colonic inflammation is ameliorated by inhibition of nitric oxide synthase. | 1995 | Gastroenterology | pmid:7541005 |
| Horikawa T et al. | Melanocyte mitogens induce both melanocyte chemokinesis and chemotaxis. | 1995 | J. Invest. Dermatol. | pmid:7530272 |
| Murakami M et al. | Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. | 1995 | J. Biol. Chem. | pmid:7559381 |
| Kurokawa H et al. | Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488097 |
| Ganbo T et al. | Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. | 1995 | Ann. Otol. Rhinol. Laryngol. | pmid:7872607 |
| Low J et al. | Cytoprotective effects of CI-959 in the rat gastric mucosa: modulation of leukocyte adhesion. | 1995 | Gastroenterology | pmid:7557089 |
| Sun J and Herman CA | The American bullfrog (Rana catesbeiana) exhibits differential cardiovascular responses to LTC4 after short- and long-term cold exposure. | 1995 | Gen. Comp. Endocrinol. | pmid:7622015 |
| Shindo K et al. | In vivo effect of prednisolone on release of leukotriene C4 in eosinophils obtained from asthmatic patients. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575557 |
| Sampson AP et al. | Persistent increase in plasma and urinary leukotrienes after acute asthma. | 1995 | Arch. Dis. Child. | pmid:7492159 |
| Zuberbier T et al. | Gangliosides enhance IgE receptor-dependent histamine and LTC4 release from human mast cells. | 1995 | Biochim. Biophys. Acta | pmid:7578275 |
| Restrick LJ et al. | Reduction in leukotriene B4 generation by bronchoalveolar lavage cells in asthma. | 1995 | Thorax | pmid:7886653 |
| Enderle GJ et al. | Different pathomechanisms of altered biliary leukotriene C4 elimination in isolated perfused rat livers. | 1995 | Biochem. Pharmacol. | pmid:7857316 |
| Fiorucci S et al. | Effect of NSAIDs on pepsinogen secretion and calcium mobilization in isolated chief cells. | 1995 | Am. J. Physiol. | pmid:7611418 |
| Sarmiento EU et al. | IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor potentiate basophil mediator release stimulated by eosinophil granule major basic protein. | 1995 | J. Immunol. | pmid:7543541 |
| De Castro CM et al. | Modulation by dexamethasone of phospholipase A2 activities in endotoxemic guinea pigs. | 1995 | J. Appl. Physiol. | pmid:8567572 |
| Engin A et al. | The protective effect of thromboxane synthetase inhibitor UK 38485 against bile duct ligation induced liver injury. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7544015 |
| Takafuji S et al. | Effects of physiologic soluble agonists on leukotriene C4 production and degranulation by human eosinophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549519 |
| Yoshida K et al. | Effect of fibronectin on the production of leukotriene C4 by eosinophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549524 |
| Datta YH et al. | Peptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical vein endothelial cells. | 1995 | Circulation | pmid:7586318 |
| Sengör T et al. | Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. | 1995 | CLAO J | pmid:7586473 |
| Sala A and Folco G | LTC4 in normal urine. | 1995 | Eur. J. Clin. Invest. | pmid:7589021 |
| Schauer U et al. | Blood eosinophils, eosinophil-derived proteins, and leukotriene C4 generation in relation to bronchial hyperreactivity in children with atopic dermatitis. | 1995 | Allergy | pmid:7604934 |
| Herron DK et al. | Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. | 1995 | J Mol Graph | pmid:8820302 |
| Juergens UR et al. | Inhibition of monocyte leukotriene B4 production after aspirin desensitization. | 1995 | J. Allergy Clin. Immunol. | pmid:7636051 |
| Gorenne I et al. | Effects of beta 2-adrenoceptor agonists on anti-IgE-induced contraction and smooth muscle reactivity in human airways. | 1995 | Br. J. Pharmacol. | pmid:7780648 |
| Ganbo T et al. | The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. | 1995 | Rhinology | pmid:8919211 |
| Karmeli F et al. | A stable nitroxide radical effectively decreases mucosal damage in experimental colitis. | 1995 | Gut | pmid:7590435 |
| Utoh J et al. | Is an increase in neutrophil leukotriene-generating capacity a specific phenomenon for cardiopulmonary bypass? | 1995 | J. Thorac. Cardiovasc. Surg. | pmid:7609558 |
| Janssen-Timmen U et al. | Expression of 5-lipoxygenase in differentiating human skin keratinocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624354 |
| Austen KF | The Paul Kallós Memorial Lecture. From slow-reacting substance of anaphylaxis to leukotriene C4 synthase. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7613129 |
| Weber M and Dahinden CA | Basophil and eosinophil activation by CC chemokines. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542061 |
| Marone G et al. | Human heart mast cells in anaphylaxis and cardiovascular disease. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542106 |
| Klapan I et al. | Arachidonic acid metabolites and sinonasal polyposis. I. Possible prognostic value. | 1995 Nov-Dec | Am J Otolaryngol | pmid:8572256 |
| Tanaka H et al. | The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. | 1995 Nov-Dec | Prostaglandins | pmid:8838238 |
| Jafarian A et al. | Effects of RS-albuterol on the development of antigen-mediated airway hyperreactivity in guinea pigs. | 1996 | Clin Rev Allergy Immunol | pmid:8866174 |
| Keppler D et al. | The function of the multidrug resistance proteins (MRP and cMRP) in drug conjugate transport and hepatobiliary excretion. | 1996 | Adv. Enzyme Regul. | pmid:8869738 |
| Tool AT et al. | The effect of salmeterol and nimesulide on chemotaxis and synthesis of PAF and LTC4 by human eosinophils. | 1996 | Eur Respir J Suppl | pmid:8871060 |
| Genovese A et al. | Role of mast cells, basophils and their mediators in adverse reactions to general anesthetics and radiocontrast media. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645973 |
| Patella V et al. | Oxatomide inhibits the release of proinflammatory mediators from human basophils and mast cells. | 1996 | Int. Arch. Allergy Immunol. | pmid:8753840 |
| Maclouf J et al. | Consequences of transcellular biosynthesis of leukotriene C4 on organ function. | 1996 | Haemostasis | pmid:8979109 |
| Tsikas D et al. | Catalytic hydrogenation of leukotriene B4 enhances sensitivity and specificity of gas chromatography-tandem mass spectrometry techniques and enables simultaneous analysis with cysteinyl leukotrienes in biological fluids. | 1996 | Anal. Biochem. | pmid:8619486 |
| Bäck M et al. | The cysteinyl-leukotriene receptor antagonist BAY u9773 is a competitive antagonist of leukotriene C4 in the guinea-pig ileum. | 1996 | Eur. J. Pharmacol. | pmid:8982726 |
| Akasaka R et al. | Effects of three different Ca(2+)-ATPase inhibitors on Ca2+ response and leukotriene release in RBL-2H3 cells. | 1996 | Inflamm. Res. | pmid:8988402 |
| Gao M et al. | Reconstitution of ATP-dependent leukotriene C4 transport by Co-expression of both half-molecules of human multidrug resistance protein in insect cells. | 1996 | J. Biol. Chem. | pmid:8910374 |
| Hamasaki Y et al. | Inhibition of leukotriene synthesis by azelastine. | 1996 | Ann. Allergy Asthma Immunol. | pmid:8630722 |
| Jutel M et al. | Influence of bee venom immunotherapy on degranulation and leukotriene generation in human blood basophils. | 1996 | Clin. Exp. Allergy | pmid:8911695 |
| Fukai F et al. | Transcellular biosynthesis of cysteinyl leukotrienes by Kupffer cell-hepatocyte cooperation in rat liver. | 1996 | Cell Biol. Int. | pmid:8858827 |
| de Paulis A et al. | Human synovial mast cells. I. Ultrastructural in situ and in vitro immunologic characterization. | 1996 | Arthritis Rheum. | pmid:8670335 |
| Horsmanheimo L et al. | Histamine and leukotriene C4 release in cutaneous mosquito-bite reactions. | 1996 | J. Allergy Clin. Immunol. | pmid:8757218 |
| Zhang H et al. | [Study on the effect and mechanism of qinggan xiehuo decoction in treatment of endotoxin-induced uveitis in rabbits]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8762423 |
| Tominaga M et al. | ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819486 |
| Crampette L et al. | Inhibition of mediator and cytokine release from dispersed nasal polyp cells by terfenadine. | 1996 | Allergy | pmid:8836342 |
| de Paulis A et al. | Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. | 1996 | J. Allergy Clin. Immunol. | pmid:8765829 |
| Planquois JM et al. | Differential inhibition by selective phosphodiesterase inhibitors of antigen, LTC4 and histamine-induced contraction of guinea-pig isolated trachea. | 1996 | Pulm Pharmacol | pmid:9160414 |
| Büchler M et al. | cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. | 1996 | J. Biol. Chem. | pmid:8662992 |
| Ionac M et al. | Oxaceprol, an atypical inhibitor of inflammation and joint damage. | 1996 | Pharmacol. Res. | pmid:8971960 |
| Leier I et al. | Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homolog of the multidrug-resistance protein. | 1996 | Eur. J. Biochem. | pmid:8973633 |
| Wei EQ et al. | Effect of ONO-1078, a leukotriene antagonist, on capsaicin- and substance P-induced bronchoconstriction and airway microvascular leakage in guinea pigs. | 1996 | Zhongguo Yao Li Xue Bao | pmid:9812736 |
| He L and Zhu J | Distinguishing antemortem from postmortem injuries by LTB4 quantification. | 1996 | Forensic Sci. Int. | pmid:8784990 |
| Kang BC et al. | Experimental asthma developed by room air contamination with cockroach allergen. | 1996 | Int. Arch. Allergy Immunol. | pmid:8917126 |
| Wu RY and Wei EQ | [Inhibitory effects of tachykinin receptor antagonists on leukotriene C4-induced cardiovascular responses in guinea pigs]. | 1996 | Yao Xue Xue Bao | pmid:9863223 |