| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis, Extrahepatic | D001651 | 7 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Cestode Infections | D002590 | 3 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Common Bile Duct Diseases | D003137 | 3 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ma KF et al. | Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model. | 2008 | World J. Gastroenterol. | pmid:18461660 |
| Laengle UW et al. | Effects of latanoprost, timolol and GLC756, a novel dopamine D(2) agonist and D(1) antagonist on LTC(4) release after rat mast cell activation. | 2007 Sep-Oct | Clin. Experiment. Ophthalmol. | pmid:17894685 |
| Zaitsu M et al. | Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx. | 2007 | Mol. Immunol. | pmid:17084457 |
| Serio KJ et al. | TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16980379 |
| Kowalski ML | Aspirin-sensitive rhinosinusitis and asthma. | 2007 | Clin Allergy Immunol | pmid:17153012 |
| Bakos E and Homolya L | Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1). | 2007 | Pflugers Arch. | pmid:17187268 |
| Nuutinen P et al. | Histamine, but not leukotriene C4, is an essential mediator in cold urticaria wheals. | 2007 | Acta Derm. Venereol. | pmid:17225008 |
| Ebihara S et al. | A simple preparation method for mouse eosinophils and their responses to anti-allergic drugs. | 2007 | Inflamm. Res. | pmid:17406808 |
| Capra V et al. | Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. | 2007 | Med Res Rev | pmid:16894531 |
| Blanchet MR et al. | Modulation of eosinophil activation in vitro by a nicotinic receptor agonist. | 2007 | J. Leukoc. Biol. | pmid:17289799 |
| Yang SL et al. | Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats. | 2007 | J. Surg. Res. | pmid:17397868 |
| Yang JJ et al. | Multidrug resistance protein 1 (MRP1) in rabbit conjunctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection. | 2007 | Pharm. Res. | pmid:17404811 |
| Mortaz E et al. | Stimulation of cysteinyl leukotriene production in mast cells by heat shock and acetylsalicylic acid. | 2007 | Eur. J. Pharmacol. | pmid:17306251 |
| Zhang L et al. | Mechanistic study on the intestinal absorption and disposition of baicalein. | 2007 | Eur J Pharm Sci | pmid:17507208 |
| Létourneau IJ et al. | Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function. | 2007 | Drug Metab. Dispos. | pmid:17494643 |
| Yang SL et al. | Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. | 2007 | Pharmacology | pmid:17496435 |
| Liebhart J et al. | Production of leukotriene C4 by peripheral blood leukocytes stimulated with anti-fcepsilonRI antibody, PMA, and fMLP does not correlate with irreversible airway obstruction in asthmatics. | 2007 | J Investig Allergol Clin Immunol | pmid:17323856 |
| Perrotton T et al. | (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. | 2007 | J. Biol. Chem. | pmid:17646169 |
| Farias SE et al. | Transcellular biosynthesis of cysteinyl leukotrienes in rat neuronal and glial cells. | 2007 | J. Neurochem. | pmid:17711426 |
| Liu YG and Luo JB | [Effects of among compositions of Herba Ephedrae decoction on genic xpression of 5-lipoxygenase activating protein, IL-4 and leukotriene C4 in asthmatic mice]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17432150 |