Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kurosawa M and Tsukagoshi H | Inhibitory effect of a thromboxane A2 synthetase inhibitor OKY-046 on bronchial hyperresponsiveness to histamine, but not on airway wall thickening, induced by intravenous administration of leukotriene C4 in guinea-pigs. | 1993 | Pulm Pharmacol | pmid:8148578 |
Hamann KJ et al. | Effects of activated eosinophils cultured from human umbilical cord blood on guinea pig trachealis. | 1993 | Am. J. Physiol. | pmid:8214090 |
Sirois MG et al. | Platelet activating factor modulates peptidoleukotriene effects on the permeability of bovine aortic endothelial cell to albumin. | 1993 | Agents Actions | pmid:8273559 |
Rainsford KD | Leukotrienes in the pathogenesis of NSAID-induced gastric and intestinal mucosal damage. | 1993 | Agents Actions | pmid:8273575 |
Butenko IG et al. | Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis georgy roots. | 1993 | Agents Actions | pmid:8273583 |
Herman CA et al. | Metabolism and cardiovascular effects of leukotrienes in the marine toad Bufo marinus. | 1993 | Gen. Comp. Endocrinol. | pmid:8262353 |
Sala A et al. | Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit. | 1993 | Br. J. Pharmacol. | pmid:8298810 |
Wallis RA and Panizzon KL | Protection from hypoxic and N-methyl-D-aspartate injury with azelastine, a leukotriene inhibitor. | 1993 | Eur. J. Pharmacol. | pmid:8405089 |
Katori M et al. | Interaction of substance P and leukotriene C4 in ethanol-induced mucosal injury of rat stomach. | 1993 | Regul. Pept. | pmid:7692504 |
Patella V et al. | Protein Fv produced during vital hepatitis is a novel activator of human basophils and mast cells. | 1993 | J. Immunol. | pmid:7693815 |
Huber W et al. | Leukotriene B4 and C4 production in isolated rat gastric mucosal cells. | 1993 | Am. J. Physiol. | pmid:8279553 |
Sawyer MM et al. | Arachidonic acid immunoregulation in lambs persistently infected with border disease virus. | 1993 | Comp. Immunol. Microbiol. Infect. Dis. | pmid:8281741 |
Devalia JL et al. | Human bronchial epithelial cell dysfunction following in vitro exposure to nitrogen dioxide. | 1993 | Eur. Respir. J. | pmid:8287947 |
MacGlashan DW and Hubbard WC | IL-3 alters free arachidonic acid generation in C5a-stimulated human basophils. | 1993 | J. Immunol. | pmid:8245471 |
Böhme M et al. | Differential inhibition by cyclosporins of primary-active ATP-dependent transporters in the hepatocyte canalicular membrane. | 1993 | FEBS Lett. | pmid:8224162 |
Ebersole JL et al. | Inflammatory mediators and immunoglobulins in GCF from healthy, gingivitis and periodontitis sites. | 1993 | J. Periodont. Res. | pmid:8263728 |
Müller D et al. | Stimulation of bile flow and inhibition of biliary secretion of taurocholate and leukotriene C4 in thioacetamide-induced liver fibrosis. | 1993 | Z Gastroenterol | pmid:7483705 |
Casolaro V et al. | Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells. | 1993 | J. Pharmacol. Exp. Ther. | pmid:7505332 |
Kurosawa M et al. | Inhibition of bronchial hyperresponsiveness to histamine induced by intravenous administration of leukotriene C4 by novel thromboxane A2 receptor antagonists ONO-NT-126 and ONO-8809 in guinea-pigs. | 1993 | Clin. Exp. Allergy | pmid:10780891 |
Westcott JY et al. | Inactivation of leukotriene C4 in the airways and subsequent urinary leukotriene E4 excretion in normal and asthmatic subjects. | 1993 | Am. Rev. Respir. Dis. | pmid:7694531 |