| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioma | D005910 | 112 associated lipids |
| Ulcer | D014456 | 16 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Drug Hypersensitivity | D004342 | 20 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
| Myocardial Ischemia | D017202 | 11 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Brain Diseases, Metabolic, Inborn | D020739 | 10 associated lipids |
| Hyperbilirubinemia | D006932 | 11 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Ear Diseases | D004427 | 7 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Genovese A et al. | Human cardiac mast cells in anaphylaxis. | 2010 | Chem Immunol Allergy | pmid:20519884 |
| Sachs-Olsen C et al. | Eoxins: a new inflammatory pathway in childhood asthma. | 2010 | J. Allergy Clin. Immunol. | pmid:20920774 |
| Akin C et al. | Mast cell activation syndrome: Proposed diagnostic criteria. | 2010 | J. Allergy Clin. Immunol. | pmid:21035176 |
| Lin TY and London CA | Characterization and modulation of canine mast cell derived eicosanoids. | 2010 | Vet. Immunol. Immunopathol. | pmid:20036014 |
| Korzekwa A et al. | Leukotrienes are auto-/paracrine factors in the bovine corpus luteum: an in vitro study. | 2010 | Reprod. Domest. Anim. | pmid:19645858 |
| Mueller CF et al. | Angiotensin II triggers release of leukotriene C4 in vascular smooth muscle cells via the multidrug resistance-related protein 1. | 2010 | Mol. Cell. Biochem. | pmid:19685171 |
| Inoue T et al. | Epigallocatechin-3-gallate inhibits mast cell degranulation, leukotriene C4 secretion, and calcium influx via mitochondrial calcium dysfunction. | 2010 | Free Radic. Biol. Med. | pmid:20510351 |
| Kawakami Y et al. | Functional expression of single-chain antibody to leukotriene C(4). | 2010 | Biochem. Biophys. Res. Commun. | pmid:20079714 |
| Di Sotto A et al. | Pharmacological and phytochemical study on a Sisymbrium officinale Scop. extract. | 2010 | J Ethnopharmacol | pmid:19969059 |
| Wunder F et al. | Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. | 2010 | Br. J. Pharmacol. | pmid:20423349 |
| Oh YC et al. | Anti-allergic activity of a platycodon root ethanol extract. | 2010 | Int J Mol Sci | pmid:20717534 |
| Okubo M et al. | Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors. | 2010 | Mol Pain | pmid:20846451 |
| Korzekwa AJ et al. | Leukotrienes modulate secretion of progesterone and prostaglandins during the estrous cycle and early pregnancy in cattle: an in vivo study. | 2010 | Reproduction | pmid:20813877 |
| Austen KF et al. | The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. | 2009 | J. Allergy Clin. Immunol. | pmid:19647860 |
| Pecaric-Petkovic T et al. | Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. | 2009 | Blood | pmid:18955562 |
| Togo K et al. | Aspirin and salicylates modulate IgE-mediated leukotriene secretion in mast cells through a dihydropyridine receptor-mediated Ca(2+) influx. | 2009 | Clin. Immunol. | pmid:19144570 |
| Ma K et al. | Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway. | 2009 | Eur. J. Pharmacol. | pmid:19087874 |
| Celik GE et al. | Effect of in vitro aspirin stimulation on basophils in patients with aspirin-exacerbated respiratory disease. | 2009 | Clin. Exp. Allergy | pmid:19486029 |
| Triggiani M et al. | Lung mast cells are a source of secreted phospholipases A2. | 2009 | J. Allergy Clin. Immunol. | pmid:19541351 |
| Suzuki Y and Ra C | Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment: aspirin modulation of IgE-dependent mast cell activation: role of aspirin-induced exacerbation of immediate allergy. | 2009 | J. Pharmacol. Sci. | pmid:19609060 |