Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Ito K et al. | Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. | 2001 | J. Biol. Chem. | pmid:11500505 |
Scoggan KA et al. | Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes. | 1997 | J. Biol. Chem. | pmid:9092565 |
Iliás A et al. | Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). | 2002 | J. Biol. Chem. | pmid:11880368 |
Carter BZ et al. | Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice. | 1997 | J. Biol. Chem. | pmid:9139674 |
Metters KM et al. | Microsomal glutathione S-transferase is the predominant leukotriene C4 binding site in cellular membranes. | 1994 | J. Biol. Chem. | pmid:8175695 |
Campbell JD et al. | Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1). | 2004 | J. Biol. Chem. | pmid:14561746 |
Bandeira-Melo C et al. | Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils. | 2001 | J. Biol. Chem. | pmid:11274187 |
Zhao Q and Chang XB | Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein 1. | 2004 | J. Biol. Chem. | pmid:15355964 |
Zhang DW et al. | Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines. | 2001 | J. Biol. Chem. | pmid:11278596 |
Furumoto Y et al. | The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production. | 2004 | J. Biol. Chem. | pmid:15355979 |
Ito K et al. | Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport. | 2001 | J. Biol. Chem. | pmid:11278867 |
Puder M and Soberman RJ | Glutathione conjugates recognize the Rossmann fold of glyceraldehyde-3-phosphate dehydrogenase. | 1997 | J. Biol. Chem. | pmid:9099752 |
Morii E and Oboki K | MITF is necessary for generation of prostaglandin D2 in mouse mast cells. | 2004 | J. Biol. Chem. | pmid:15375155 |
Situ D et al. | Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter. | 2004 | J. Biol. Chem. | pmid:15208328 |
Zhang DW et al. | Identification of a nonconserved amino acid residue in multidrug resistance protein 1 important for determining substrate specificity: evidence for functional interaction between transmembrane helices 14 and 17. | 2001 | J. Biol. Chem. | pmid:11429411 |
Loe DW et al. | Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. | 1996 | J. Biol. Chem. | pmid:8621643 |
Gao M et al. | Reconstitution of ATP-dependent leukotriene C4 transport by Co-expression of both half-molecules of human multidrug resistance protein in insect cells. | 1996 | J. Biol. Chem. | pmid:8910374 |
Chang WC and Parekh AB | Close functional coupling between Ca2+ release-activated Ca2+ channels, arachidonic acid release, and leukotriene C4 secretion. | 2004 | J. Biol. Chem. | pmid:15133023 |
Chang WC et al. | Local Ca2+ influx through Ca2+ release-activated Ca2+ (CRAC) channels stimulates production of an intracellular messenger and an intercellular pro-inflammatory signal. | 2008 | J. Biol. Chem. | pmid:18156181 |
Haimeur A et al. | Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity. | 2002 | J. Biol. Chem. | pmid:12186871 |
Zhang DW et al. | Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17. | 2002 | J. Biol. Chem. | pmid:11925441 |
Loe DW et al. | ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. | 1996 | J. Biol. Chem. | pmid:8621644 |
Maekawa A et al. | Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. | 2002 | J. Biol. Chem. | pmid:11932261 |
Ahamed J and Ali H | Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. | 2002 | J. Biol. Chem. | pmid:11934880 |
Gao M et al. | Multidrug resistance protein. Identification of regions required for active transport of leukotriene C4. | 1998 | J. Biol. Chem. | pmid:9553138 |
Mao Q et al. | GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain. | 2002 | J. Biol. Chem. | pmid:12034727 |
Sakamoto H et al. | Involvement of phospholipid hydroperoxide glutathione peroxidase in the modulation of prostaglandin D2 synthesis. | 2000 | J. Biol. Chem. | pmid:11010961 |
Fernández SB et al. | Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells. | 2002 | J. Biol. Chem. | pmid:12060660 |
Leslie EM et al. | Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog. | 2001 | J. Biol. Chem. | pmid:11375986 |
Saino H et al. | The catalytic architecture of leukotriene C4 synthase with two arginine residues. | 2011 | J. Biol. Chem. | pmid:21454538 |
He P et al. | Oxidative stress suppresses cysteinyl leukotriene generation by mouse bone marrow-derived mast cells. | 2011 | J. Biol. Chem. | pmid:21233206 |
Koike K et al. | Multiple membrane-associated tryptophan residues contribute to the transport activity and substrate specificity of the human multidrug resistance protein, MRP1. | 2002 | J. Biol. Chem. | pmid:12388549 |
Iram SH and Cole SP | Expression and function of human MRP1 (ABCC1) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2. | 2011 | J. Biol. Chem. | pmid:21177244 |
Büchler M et al. | cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. | 1996 | J. Biol. Chem. | pmid:8662992 |
Blokzijl H et al. | Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease. | 2008 | J. Biol. Chem. | pmid:18838379 |
Yang R et al. | ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transport. | 2003 | J. Biol. Chem. | pmid:12783859 |
Muñoz NM et al. | Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. | 2003 | J. Biol. Chem. | pmid:12796497 |
Zhang DW et al. | Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state. | 2003 | J. Biol. Chem. | pmid:12954620 |
Niegowski D et al. | Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism. | 2014 | J. Biol. Chem. | pmid:24366866 |
Konno T et al. | Identification of domains participating in the substrate specificity and subcellular localization of the multidrug resistance proteins MRP1 and MRP2. | 2003 | J. Biol. Chem. | pmid:12682044 |
Yamane Y et al. | Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress. | 1998 | J. Biol. Chem. | pmid:9813007 |
Carter BZ et al. | gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. | 1998 | J. Biol. Chem. | pmid:9774450 |
Wijewickrama GT et al. | Systematic evaluation of transcellular activities of secretory phospholipases A2. High activity of group V phospholipases A2 to induce eicosanoid biosynthesis in neighboring inflammatory cells. | 2006 | J. Biol. Chem. | pmid:16476735 |
Hipfner DR et al. | Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein. | 1999 | J. Biol. Chem. | pmid:10336431 |
Leier I et al. | The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. | 1994 | J. Biol. Chem. | pmid:7961706 |
Payen LF et al. | Role of carboxylate residues adjacent to the conserved core Walker B motifs in the catalytic cycle of multidrug resistance protein 1 (ABCC1). | 2003 | J. Biol. Chem. | pmid:12882957 |
Bannenberg G et al. | Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. | 1999 | J. Biol. Chem. | pmid:9890956 |
Kanaoka Y et al. | Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. | 2013 | J. Biol. Chem. | pmid:23504326 |
Bukiya AN et al. | Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4. | 2014 | J. Biol. Chem. | pmid:25371198 |
Murakami M et al. | Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. | 1995 | J. Biol. Chem. | pmid:7559381 |
Gao M et al. | Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1. | 2000 | J. Biol. Chem. | pmid:10777615 |
Li L et al. | Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. | 1998 | J. Biol. Chem. | pmid:9632674 |
Perrotton T et al. | (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. | 2007 | J. Biol. Chem. | pmid:17646169 |
Bates ME et al. | ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesis. | 2000 | J. Biol. Chem. | pmid:10753897 |
Thompson C et al. | Signaling by the cysteinyl-leukotriene receptor 2. Involvement in chemokine gene transcription. | 2008 | J. Biol. Chem. | pmid:18048362 |
Qian YM et al. | Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. | 2001 | J. Biol. Chem. | pmid:11102445 |
Murakami M et al. | Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms. | 2001 | J. Biol. Chem. | pmid:11106649 |
Falcón-Pérez JM et al. | Functional domain analysis of the yeast ABC transporter Ycf1p by site-directed mutagenesis. | 1999 | J. Biol. Chem. | pmid:10438540 |
Alswied A and Parekh AB | Ca2+ Influx through Store-operated Calcium Channels Replenishes the Functional Phosphatidylinositol 4,5-Bisphosphate Pool Used by Cysteinyl Leukotriene Type I Receptors. | 2015 | J. Biol. Chem. | pmid:26468289 |
Cole SP | Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter. | 2014 | J. Biol. Chem. | pmid:25281745 |
Stride BD et al. | Localization of a substrate specificity domain in the multidrug resistance protein. | 1999 | J. Biol. Chem. | pmid:10428874 |
Heise CE et al. | Characterization of the human cysteinyl leukotriene 2 receptor. | 2000 | J. Biol. Chem. | pmid:10851239 |
Conseil G et al. | Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1). | 2006 | J. Biol. Chem. | pmid:16230346 |
Bowers RC et al. | A novel glutathione containing eicosanoid (FOG7) chemotactic for human granulocytes. | 2000 | J. Biol. Chem. | pmid:10924496 |
Ito K et al. | Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. | 1998 | J. Biol. Chem. | pmid:9430713 |
Westlake CJ et al. | Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region. | 2004 | J. Biol. Chem. | pmid:15459206 |
Bakos E et al. | Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain. | 1998 | J. Biol. Chem. | pmid:9822694 |
Christmas P et al. | Membrane localization and topology of leukotriene C4 synthase. | 2002 | J. Biol. Chem. | pmid:12023288 |
Hui Y et al. | The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. | 2001 | J. Biol. Chem. | pmid:11591709 |
Garcia C et al. | Effects of synthetic peptido-leukotrienes on bone resorption in vitro. | 1996 | J. Bone Miner. Res. | pmid:8992883 |
Mayer R et al. | Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. | 1995 | J. Cell Biol. | pmid:7559771 |
Hong JT and Glauert HP | Comitogenicity of eicosanoids and the peroxisome proliferator ciprofibrate in cultured rat hepatocytes. | 1996 | J. Cell. Physiol. | pmid:8908198 |
Geirsson A et al. | Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. | 1998 | J. Cell. Physiol. | pmid:9731750 |
Wilborn J et al. | Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. | 1996 | J. Clin. Invest. | pmid:8621765 |
Soberman RJ and Christmas P | The organization and consequences of eicosanoid signaling. | 2003 | J. Clin. Invest. | pmid:12697726 |
Sullivan GF et al. | Regulation of expression of the multidrug resistance protein MRP1 by p53 in human prostate cancer cells. | 2000 | J. Clin. Invest. | pmid:10792001 |
Talbot SF et al. | Accumulation of leukotriene C4 and histamine in human allergic skin reactions. | 1985 | J. Clin. Invest. | pmid:2411760 |
Fadok VA et al. | Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. | 1998 | J. Clin. Invest. | pmid:9466984 |
Romanelli F et al. | Arachidonic acid and its metabolites effects on testosterone production by rat Leydig cells. | 1995 | J. Endocrinol. Invest. | pmid:7615904 |
Murakami M et al. | The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. | 1995 | J. Exp. Med. | pmid:7540649 |
Forssmann U et al. | Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. | 1997 | J. Exp. Med. | pmid:9182688 |
Takano T et al. | Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. | 1997 | J. Exp. Med. | pmid:9151906 |
Gurish MF and Austen KF | The diverse roles of mast cells. | 2001 | J. Exp. Med. | pmid:11435478 |
Weber M et al. | Deletion of the NH2-terminal residue converts monocyte chemotactic protein 1 from an activator of basophil mediator release to an eosinophil chemoattractant. | 1996 | J. Exp. Med. | pmid:8627182 |
Henderson WR et al. | The importance of leukotrienes in airway inflammation in a mouse model of asthma. | 1996 | J. Exp. Med. | pmid:8879219 |
Bandeira-Melo C et al. | Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. | 2002 | J. Exp. Med. | pmid:12235216 |
Fiore S et al. | Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. | 1994 | J. Exp. Med. | pmid:8006586 |
Nishikawa M et al. | Effect of leukotriene C4D4 antagonist on colonic damage induced by intracolonic administration of trinitrobenzene sulfonic acid in rats. | 1995 | J. Gastroenterol. | pmid:7719412 |
Uemura M et al. | Cysteinyl leukotrienes in the bile of patients with obstructive jaundice. | 2002 | J. Gastroenterol. | pmid:12424566 |
Zhang X et al. | Complex role of STIM1 in the activation of store-independent Orai1/3 channels. | 2014 | J. Gen. Physiol. | pmid:24567509 |
Müller D et al. | Bile ductular proliferation and altered leukotriene elimination in thioacetamide-induced fibrosis of rat liver. | 1996 | J. Hepatol. | pmid:8912155 |
Richter L et al. | Increased biliary secretion of cysteinyl-leukotrienes in human bile duct obstruction. | 1996 | J. Hepatol. | pmid:8938552 |
Miura K et al. | Differences in functional consequences and signal transduction induced by IL-3, IL-5, and nerve growth factor in human basophils. | 2001 | J. Immunol. | pmid:11490016 |
Zhu X et al. | Role of mitogen-activated protein kinase-mediated cytosolic phospholipase A2 activation in arachidonic acid metabolism in human eosinophils. | 2001 | J. Immunol. | pmid:11418683 |
Monahan J et al. | Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. | 1997 | J. Immunol. | pmid:9378992 |
MacGlashan DW and Hubbard WC | IL-3 alters free arachidonic acid generation in C5a-stimulated human basophils. | 1993 | J. Immunol. | pmid:8245471 |
Patella V et al. | Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. | 1995 | J. Immunol. | pmid:7533185 |
Nagata M et al. | Eosinophil adhesion to vascular cell adhesion molecule-1 activates superoxide anion generation. | 1995 | J. Immunol. | pmid:7543540 |
Sarmiento EU et al. | IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor potentiate basophil mediator release stimulated by eosinophil granule major basic protein. | 1995 | J. Immunol. | pmid:7543541 |
Campbell EM et al. | Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. | 1999 | J. Immunol. | pmid:10438957 |