LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Periapical Periodontitis D010485 6 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Angina Pectoris D000787 27 associated lipids
Hyperbilirubinemia, Hereditary D006933 3 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Drug Eruptions D003875 30 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Mesenteric Vascular Occlusion D008641 4 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Cestode Infections D002590 3 associated lipids
Neointima D058426 3 associated lipids
Asbestosis D001195 8 associated lipids
Phlebitis D010689 1 associated lipids
Picornaviridae Infections D010850 4 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Le Poole IC et al. Organotypic culture of human skin to study melanocyte migration. 1994 Pigment Cell Res. pmid:8072944
Ducep JB et al. Synthesis of 5- and 6-fluoro derivatives of 5,8,14-eicosatrienoic and 5,8,11,14-eicosatetraenoic acids. Effects of fluorinated arachidonic acids on leukotriene C4 production by macrophages. 1994 Bioorg. Med. Chem. pmid:7922133
Ibe BO et al. Plasma and urinary leukotrienes in sickle cell disease: possible role in the inflammatory process. 1994 Eur. J. Clin. Invest. pmid:8187808
Mayatepek E et al. Impaired synthesis of lipoxygenase products in glutathione synthetase deficiency. 1994 Pediatr. Res. pmid:8190517
Shimizu T et al. Effects of pancreatic and snake venom phospholipase A2 on the generation of leukotriene B4 and C4 by human leukocytes in vitro. 1994 Pancreas pmid:8108369
Fauler J et al. Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis. 1994 Arthritis Rheum. pmid:8129769
Müller M et al. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7809167
HasanoÄŸlu E et al. The role of prostanoids in the complications of extracorporeal shock wave lithotripsy (ESWL) in children. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846111
Liu L et al. Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum. 1994 Arzneimittelforschung pmid:7848335
Schuil PJ et al. Histamine and leukotriene C4 effects on in vitro ciliary beat frequency of human upper respiratory cilia. 1994 Eur Arch Otorhinolaryngol pmid:7848641
Currie S et al. Phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in MCII mast cells mediated by high-affinity Fc receptor for IgE. 1994 Biochem. J. pmid:7818499
Teshigawara H and Moriya Y The role of leukotriene C4 in biphasic release of histamine from mouse mastocytoma cell line (P-815). 1994 Gen. Pharmacol. pmid:7530673
Raible DG Erythrocytes increase leukotriene C4 release from human eosinophils: characterization and examination of possible mechanisms. 1994 J. Leukoc. Biol. pmid:8027672
Mitsuhashi T et al. Increased production of eicosanoids, TXA2, PGI2 and LTC4 in experimental spinal cord injuries. 1994 Paraplegia pmid:7970857
Volland H et al. Enzyme immunometric assay for leukotriene C4. 1994 J. Immunol. Methods pmid:7930643
Chen CR et al. Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids. 1994 Am. J. Respir. Crit. Care Med. pmid:8111595
Büyükgebiz O et al. Captopril increases endothelin serum concentrations and preserves intestinal mucosa after mesenteric ischemia-reperfusion injury. 1994 Res Exp Med (Berl) pmid:7536337
Nagashima T et al. The effect of leukotriene C4 on the permeability of brain capillary endothelial cell monolayer. 1994 Acta Neurochir Suppl (Wien) pmid:7976646
Amon U et al. Control function of protein kinase C isozymes on leukotriene generation from human basophils? 1994 Agents Actions pmid:7976816
Medina L et al. Leukotriene C4 upregulates collagenase expression and synthesis in human lung fibroblasts. 1994 Biochim. Biophys. Acta pmid:7981229
Votta BJ and Bertolini DR Cytokine suppressive anti-inflammatory compounds inhibit bone resorption in vitro. 1994 Sep-Oct Bone pmid:7980964
Enomoto F et al. [Evaluation of arachidonic acid metabolites in experimental rat otitis media with effusion]. 1995 Nippon Jibiinkoka Gakkai Kaiho pmid:7629649
Gimpel JA et al. Reduction of reperfusion injury of human myocardium by allopurinol: a clinical study. 1995 Free Radic. Biol. Med. pmid:7649495
Wettstein M et al. Metabolism of cysteinyl leukotrienes in the perfused rat liver: the influence of endotoxin pretreatment and the cellular hydration state. 1995 Hepatology pmid:7601416
Meier HL et al. Simultaneous initiation of degranulation and inhibition of leukotriene release by soman in human basophils. 1995 Int. J. Immunopharmacol. pmid:7545649
Ono S et al. [Role of peptide leukotrienes in monocrotaline-induced lung disease]. 1995 Nihon Kyobu Shikkan Gakkai Zasshi pmid:8821996
Kristjánsson S et al. Leukotriene B4 and C4 generation by human leukocytes after ex vivo stimulation with Ca-ionophore and opsonized zymosan in children with atopic asthma. 1995 Pediatr Allergy Immunol pmid:8750311
Van Dijk JP et al. Nicotine inhibits cytokine synthesis by mouse colonic mucosa. 1995 Eur. J. Pharmacol. pmid:7664807
Patella V et al. Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. 1995 J. Immunol. pmid:7533185
Thomas JW et al. Potent interleukin 3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7537376
Smit NP et al. Stimulation of cultured melanocytes in medium containing a serum substitute: Ultroser-G. 1995 Pigment Cell Res. pmid:7540755
Malaviya R and Abraham SN Interaction of bacteria with mast cells. 1995 Meth. Enzymol. pmid:7476393
Yakubu MA et al. Hematoma-induced enhanced cerebral vasoconstrictions to leukotriene C4 and endothelin-1 in piglets: role of prostanoids. 1995 Pediatr. Res. pmid:7478789
Buyukgebiz O et al. Allopurinol inhibits endothelin release after mesenteric ischemia-reperfusion injury. 1995 Transplant. Proc. pmid:7482880
Rachmilewitz D et al. Sulfhydryl blocker-induced rat colonic inflammation is ameliorated by inhibition of nitric oxide synthase. 1995 Gastroenterology pmid:7541005
Franco L and Velo GP Eicosanoid and gastroprotection by copper derivatives and NDGA. 1995 Inflamm. Res. pmid:7552579
Kanwar S et al. Leukotriene C4/D4 induces P-selectin and sialyl Lewis(x)-dependent alterations in leukocyte kinetics in vivo. 1995 Circ. Res. pmid:7554141
Mayer R et al. Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. 1995 J. Cell Biol. pmid:7559771
Prié S et al. Leukotriene C4 receptors on guinea pig tracheocytes. 1995 J. Pharmacol. Exp. Ther. pmid:7562565
Hom JT et al. The amyloidogenic peptide human amylin augments the inflammatory activities of eosinophils. 1995 J. Leukoc. Biol. pmid:7595053
Fiorucci S et al. Effect of NSAIDs on pepsinogen secretion and calcium mobilization in isolated chief cells. 1995 Am. J. Physiol. pmid:7611418
Nagata M et al. Eosinophil adhesion to vascular cell adhesion molecule-1 activates superoxide anion generation. 1995 J. Immunol. pmid:7543540
Sarmiento EU et al. IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor potentiate basophil mediator release stimulated by eosinophil granule major basic protein. 1995 J. Immunol. pmid:7543541
Engin A et al. The protective effect of thromboxane synthetase inhibitor UK 38485 against bile duct ligation induced liver injury. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7544015
Takafuji S et al. Effects of physiologic soluble agonists on leukotriene C4 production and degranulation by human eosinophils. 1995 Int. Arch. Allergy Immunol. pmid:7549519
Hubbard NE and Erickson KL Role of 5'-lipoxygenase metabolites in the activation of peritoneal macrophages for tumoricidal function. 1995 Cell. Immunol. pmid:7842477
Yamaya M et al. Epithelial modulation of leukotriene-C4-induced human tracheal smooth muscle contraction. 1995 Am. J. Respir. Crit. Care Med. pmid:7881688
Gorenne I et al. Antagonism of leukotriene responses in human airways by BAY x7195. 1995 Eur. J. Pharmacol. pmid:7796856
Juergens UR et al. Inhibition of monocyte leukotriene B4 production after aspirin desensitization. 1995 J. Allergy Clin. Immunol. pmid:7636051
Ganbo T et al. The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. 1995 Rhinology pmid:8919211