Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kimura Y et al. | Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. | 1995 | J Ethnopharmacol | pmid:7776662 |
Sato H et al. | Biological characteristics of chronic eosinophilic leukemia cells with a t(2;5)(p23;q35) translocation. | 1995 | Leuk. Lymphoma | pmid:8590853 |
Herman CA et al. | Leukotriene C4-stimulated contractions in bullfrog lung are affected by cold acclimation and calcium antagonists. | 1995 | Prostaglandins | pmid:7480797 |
Lam BK et al. | Leukotriene C4 synthase. | 1995 | J Lipid Mediat Cell Signal | pmid:8777577 |
Wang D et al. | Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888790 |
Egger D et al. | IL-4 renders mast cells functionally responsive to endothelin-1. | 1995 | J. Immunol. | pmid:7530742 |
Patella V et al. | The antineoplastic bryostatins affect human basophils and mast cells differently. | 1995 | Blood | pmid:7532037 |
Weber M et al. | Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3. | 1995 | J. Immunol. | pmid:7535823 |
Romanelli F et al. | Arachidonic acid and its metabolites effects on testosterone production by rat Leydig cells. | 1995 | J. Endocrinol. Invest. | pmid:7615904 |
Patella V et al. | Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. | 1995 | J. Immunol. | pmid:7533185 |
Brady HR et al. | Lipoxygenase product formation and cell adhesion during neutrophil-glomerular endothelial cell interaction. | 1995 | Am. J. Physiol. | pmid:7840235 |
Kurokawa H et al. | Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488097 |
Ganbo T et al. | Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. | 1995 | Ann. Otol. Rhinol. Laryngol. | pmid:7872607 |
Sun J and Herman CA | The American bullfrog (Rana catesbeiana) exhibits differential cardiovascular responses to LTC4 after short- and long-term cold exposure. | 1995 | Gen. Comp. Endocrinol. | pmid:7622015 |
Shindo K et al. | In vivo effect of prednisolone on release of leukotriene C4 in eosinophils obtained from asthmatic patients. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575557 |
Zuberbier T et al. | Gangliosides enhance IgE receptor-dependent histamine and LTC4 release from human mast cells. | 1995 | Biochim. Biophys. Acta | pmid:7578275 |
Enderle GJ et al. | Different pathomechanisms of altered biliary leukotriene C4 elimination in isolated perfused rat livers. | 1995 | Biochem. Pharmacol. | pmid:7857316 |
Ramondt J et al. | Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. | 1995 | Prostaglandins | pmid:7792392 |
Austen KF | The Paul Kallós Memorial Lecture. From slow-reacting substance of anaphylaxis to leukotriene C4 synthase. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7613129 |
Weber M and Dahinden CA | Basophil and eosinophil activation by CC chemokines. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542061 |
Marone G et al. | Human heart mast cells in anaphylaxis and cardiovascular disease. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542106 |
Klapan I et al. | Arachidonic acid metabolites and sinonasal polyposis. I. Possible prognostic value. | 1995 Nov-Dec | Am J Otolaryngol | pmid:8572256 |
Tanaka H et al. | The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. | 1995 Nov-Dec | Prostaglandins | pmid:8838238 |
Tsikas D et al. | Catalytic hydrogenation of leukotriene B4 enhances sensitivity and specificity of gas chromatography-tandem mass spectrometry techniques and enables simultaneous analysis with cysteinyl leukotrienes in biological fluids. | 1996 | Anal. Biochem. | pmid:8619486 |
Loe DW et al. | Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. | 1996 | J. Biol. Chem. | pmid:8621643 |
Wilborn J et al. | Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. | 1996 | J. Clin. Invest. | pmid:8621765 |
Meltzer SS et al. | Inhibition of exercise-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8630575 |
Gao M et al. | Reconstitution of ATP-dependent leukotriene C4 transport by Co-expression of both half-molecules of human multidrug resistance protein in insect cells. | 1996 | J. Biol. Chem. | pmid:8910374 |
Hamasaki Y et al. | Inhibition of leukotriene synthesis by azelastine. | 1996 | Ann. Allergy Asthma Immunol. | pmid:8630722 |
Jutel M et al. | Influence of bee venom immunotherapy on degranulation and leukotriene generation in human blood basophils. | 1996 | Clin. Exp. Allergy | pmid:8911695 |
Omar HM et al. | Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury. | 1996 | Inflamm. Res. | pmid:8912018 |
Müller D et al. | Bile ductular proliferation and altered leukotriene elimination in thioacetamide-induced fibrosis of rat liver. | 1996 | J. Hepatol. | pmid:8912155 |
Sedgwick JB et al. | Effect of isolation protocol on eosinophil function: Percoll gradients versus immunomagnetic beads. | 1996 | J. Immunol. Methods | pmid:8914593 |
Pulaski L et al. | Identification of the multidrug-resistance protein (MRP) as the glutathione-S-conjugate export pump of erythrocytes. | 1996 | Eur. J. Biochem. | pmid:8917467 |
Brock TG et al. | Effects of granulocyte-macrophage colony-stimulating factor on eicosanoid production by mononuclear phagocytes. | 1996 | J. Immunol. | pmid:8786314 |
Garcia C et al. | Effects of synthetic peptido-leukotrienes on bone resorption in vitro. | 1996 | J. Bone Miner. Res. | pmid:8992883 |
Henderson WR et al. | The importance of leukotrienes in airway inflammation in a mouse model of asthma. | 1996 | J. Exp. Med. | pmid:8879219 |
Horsmanheimo L et al. | Histamine and leukotriene C4 release in cutaneous mosquito-bite reactions. | 1996 | J. Allergy Clin. Immunol. | pmid:8757218 |
Zhang H et al. | [Study on the effect and mechanism of qinggan xiehuo decoction in treatment of endotoxin-induced uveitis in rabbits]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8762423 |
Tominaga M et al. | ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819486 |
de Paulis A et al. | Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. | 1996 | J. Allergy Clin. Immunol. | pmid:8765829 |
Büchler M et al. | cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. | 1996 | J. Biol. Chem. | pmid:8662992 |
Daffonchio L et al. | Protective activity of ketoprofen lysine salt against the pulmonary effects induced by bradykinin in guinea-pigs. | 1996 | Inflamm. Res. | pmid:8737750 |
Shichinohe K et al. | Effect of M-711 on experimental skin reactions induced by chemical mediators in rats. | 1996 | J. Vet. Med. Sci. | pmid:8741601 |
Ionac M et al. | Oxaceprol, an atypical inhibitor of inflammation and joint damage. | 1996 | Pharmacol. Res. | pmid:8971960 |
Leier I et al. | Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homolog of the multidrug-resistance protein. | 1996 | Eur. J. Biochem. | pmid:8973633 |
Tang DG et al. | Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8643560 |
Papayianni A et al. | Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. | 1996 | J. Immunol. | pmid:8690917 |
Batirel HF et al. | The effect of aqueous garlic extract on the levels of arachidonic acid metabolites (leukotriene C4 and prostaglandin E2) in rat forebrain after ischemia-reperfusion injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804127 |
Shraga-Levine Z et al. | Arachidonic acid and lipoxygenase products stimulate protein kinase C beta mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin-releasing hormone action. | 1996 | Biochem. J. | pmid:8687415 |