| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Carcinoma, Small Cell | D018288 | 21 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dichlberger A et al. | Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells. | 2014 | J. Lipid Res. | pmid:25114172 |
| Xiang Y et al. | Anti-inflammatory effect of acetylpuerarin on eicosanoid signaling pathway in primary rat astrocytes. | 2014 | J. Mol. Neurosci. | pmid:24026619 |
| Kawakami Y et al. | Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies. | 2014 | Biochim. Biophys. Acta | pmid:24361619 |
| Xu R et al. | Novel polyhydroxylated steroids from the East China Sea gorgonian Echinogorgia sassapo reticulata with suppressive activity of leukotriene C4 generation and degranulation in bone marrow-derived mast cells. | 2014 | J Asian Nat Prod Res | pmid:24437431 |
| Gao YB et al. | Low temperature inhibits pollen tube growth by disruption of both tip-localized reactive oxygen species and endocytosis in Pyrus bretschneideri Rehd. | 2014 | Plant Physiol. Biochem. | pmid:24321875 |
| Bertin J et al. | Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4⺠T cells across an in vitro blood-brain barrier model. | 2014 | Virology | pmid:24725939 |
| Zhang X et al. | Complex role of STIM1 in the activation of store-independent Orai1/3 channels. | 2014 | J. Gen. Physiol. | pmid:24567509 |
| Pinho BR et al. | Modulation of basophils' degranulation and allergy-related enzymes by monomeric and dimeric naphthoquinones. | 2014 | PLoS ONE | pmid:24587235 |
| Bukiya AN et al. | Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4. | 2014 | J. Biol. Chem. | pmid:25371198 |
| Linares Segovia B et al. | Parameters of lung inflammation in asthmatic as compared to healthy children in a contaminated city. | 2014 | BMC Pulm Med | pmid:25000942 |
| Cole SP | Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter. | 2014 | J. Biol. Chem. | pmid:25281745 |
| Lee JF et al. | Lipoxygenase pathway mediates increases of airway resistance and lung inflation induced by exposure to nanotitanium dioxide in rats. | 2014 | Oxid Med Cell Longev | pmid:24693335 |
| Syslová K et al. | Immunomagnetic molecular probe with UHPLC-MS/MS: a promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes. | 2013 Jul-Aug | J Pharm Biomed Anal | pmid:23644905 |
| Lechowski S et al. | Combined arginine and glutamine decrease release of de novo synthesized leukotrienes and expression of proinflammatory cytokines in activated human intestinal mast cells. | 2013 | Eur J Nutr | pmid:22527286 |
| Macglashan DW and Saini SS | Omalizumab increases the intrinsic sensitivity of human basophils to IgE-mediated stimulation. | 2013 | J. Allergy Clin. Immunol. | pmid:23791510 |
| Zhang X et al. | Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels. | 2013 | Mol. Cell. Biol. | pmid:23878392 |
| Jung HW et al. | Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis. | 2013 | Int. Immunopharmacol. | pmid:23643816 |
| González-Cobos JC et al. | Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia. | 2013 | Circ. Res. | pmid:23349245 |
| Kanaoka Y et al. | Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. | 2013 | J. Biol. Chem. | pmid:23504326 |
| Ikeno Y et al. | Wasp venom allergy: effect of anti-IgE antibody on wasp venom anaphylaxis in a mouse model. | 2013 | Asian Pac. J. Allergy Immunol. | pmid:23859410 |