| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Carcinoma, Small Cell | D018288 | 21 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| de Paulis A et al. | Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs. | 1997 | Arthritis Rheum. | pmid:9082935 |
| de Paulis A et al. | Human synovial mast cells. I. Ultrastructural in situ and in vitro immunologic characterization. | 1996 | Arthritis Rheum. | pmid:8670335 |
| Fauler J et al. | Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis. | 1994 | Arthritis Rheum. | pmid:8129769 |
| Amat M et al. | Leukotriene A4 hydrolase and leukotriene C4 synthase activities in human chondrocytes: transcellular biosynthesis of Leukotrienes during granulocyte-chondrocyte interaction. | 1998 | Arthritis Rheum. | pmid:9751098 |
| Küsters S et al. | Effects of antihistamines on leukotriene and cytokine release from dispersed nasal polyp cells. | 2002 | Arzneimittelforschung | pmid:11878205 |
| Ishizuka Y et al. | Effect of 1,6-dihydro-2[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidineca rboxyli c acid on ethanol-induced microvascular injury in rats. | 1996 | Arzneimittelforschung | pmid:9125278 |
| Llupià J et al. | Comparative antiallergic effects of second-generation H1-antihistamines ebastine, cetirizine and loratadine in preclinical models. | 2003 | Arzneimittelforschung | pmid:12642964 |
| Liu L et al. | Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum. | 1994 | Arzneimittelforschung | pmid:7848335 |
| Mita H and Shida T | Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes. | 1995 | Arzneimittelforschung | pmid:7893266 |
| Yamada N et al. | Pharmacological profile of the novel, potent and selective peptide leukotriene antagonist (E)-2,2-diethyl-3'-[2-[2-(4-isopropyl)thiazolyl]ethenyl]succinanilic acid. | 1994 | Arzneimittelforschung | pmid:8053974 |
| Bando T et al. | Inhibitory effect of aerosol administration of a sulfidopeptide leukotriene antagonist on bronchoconstriction induced by antigen inhalation in guinea pigs. | 1994 | Arzneimittelforschung | pmid:8053975 |
| King BO et al. | Tirofiban administration attenuates platelet and platelet-neutrophil conjugation but not neutrophil degranulation during in vitro VAD circulation. | 2001 May-Jun | ASAIO J. | pmid:11374774 |
| Ikeno Y et al. | Wasp venom allergy: effect of anti-IgE antibody on wasp venom anaphylaxis in a mouse model. | 2013 | Asian Pac. J. Allergy Immunol. | pmid:23859410 |
| Porreca E et al. | Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. | 1995 | Atherosclerosis | pmid:7755646 |
| Kamohara M et al. | Functional characterization of cysteinyl leukotriene CysLT(2) receptor on human coronary artery smooth muscle cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11587533 |
| Nagy E et al. | Increased transcript level of poly(ADP-ribose) polymerase (PARP-1) in human tricuspid compared with bicuspid aortic valves correlates with the stenosis severity. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22450322 |
| Chuman Y et al. | Characterization of the ATP-dependent LTC4 transporter in cisplatin-resistant human KB cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806607 |
| Nishio T et al. | Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10973807 |
| Seki K et al. | Oxidative stress potentially enhances FcεRI-mediated leukotriene C4 release dependent on the late-phase increase of intracellular glutathione in mast cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23998930 |
| Niwa Y et al. | Opposite effects of PU.1 on mast cell stimulation. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18680724 |
| Sur R et al. | Role of Janus kinase-2 in IgE receptor-mediated leukotriene C4 production by mast cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19835845 |
| Nakano R et al. | A leukotriene receptor antagonist, ONO-1078, modulates drug sensitivity and leukotriene C4 efflux in lung cancer cells expressing multidrug resistance protein. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9790952 |
| Ramires R et al. | Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474500 |
| Tsuruoka S et al. | Functional analysis of ABCA8, a new drug transporter. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12379217 |
| Söderström M et al. | Expression of leukotriene C4 synthase mRNA by the choroid plexus in mouse brain suggests novel neurohormone functions of cysteinyl leukotrienes. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12878209 |
| Kawakami Y et al. | Functional expression of single-chain antibody to leukotriene C(4). | 2010 | Biochem. Biophys. Res. Commun. | pmid:20079714 |
| Malaviya R and Uckun FM | Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10208864 |
| Kurokawa H et al. | Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488097 |
| Priebe W et al. | Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647783 |
| Shindo K et al. | In vivo effect of prednisolone on release of leukotriene C4 in eosinophils obtained from asthmatic patients. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575557 |
| Ren XQ et al. | Functional comparison between YCF1 and MRP1 expressed in Sf21 insect cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10753671 |
| Koshino T et al. | Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9642160 |
| Nakamura T et al. | Direct interaction between a quinoline derivative, MS-209, and multidrug resistance protein (MRP) in human gastric cancer cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10049760 |
| Loe DW et al. | Structure-activity studies of verapamil analogs that modulate transport of leukotriene C(4) and reduced glutathione by multidrug resistance protein MRP1. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10973801 |
| Koike K et al. | Mapping of the MRPm5 epitope to the cytosolic region between transmembrane helices 13 and 14 in the drug and organic anion transporter, MRP1 (ABCC1). | 2004 | Biochem. Biophys. Res. Commun. | pmid:14975760 |
| Takasaki J et al. | The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10913337 |
| Maury G et al. | Racemic LTA4 methyl ester bioconversion into LTC4 methyl ester by various glutathione S-transferases. | 1987 | Biochem. Int. | pmid:3125835 |
| Brock TG et al. | Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages. | 1998 | Biochem. J. | pmid:9445378 |
| Rigato I et al. | The human multidrug-resistance-associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin. | 2004 | Biochem. J. | pmid:15245331 |
| Jedlitschky G et al. | ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. | 1997 | Biochem. J. | pmid:9355767 |
| Lee SH and Altenberg GA | Transport of leukotriene C4 by a cysteine-less multidrug resistance protein 1 (MRP1). | 2003 | Biochem. J. | pmid:12398766 |
| Currie S et al. | Phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in MCII mast cells mediated by high-affinity Fc receptor for IgE. | 1994 | Biochem. J. | pmid:7818499 |
| Leier I et al. | ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. | 1996 | Biochem. J. | pmid:8670053 |
| Shraga-Levine Z et al. | Arachidonic acid and lipoxygenase products stimulate protein kinase C beta mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin-releasing hormone action. | 1996 | Biochem. J. | pmid:8687415 |
| Takagi S et al. | The pathophysiological roles of heterogeneous eosinophils in allergic rhinitis caused by house dust mites. | 1995 | Biochem. Mol. Biol. Int. | pmid:7581000 |
| Ibe BO et al. | Leukotriene synthesis by isolated perinatal ovine intrapulmonary vessels correlates with age-related changes in 5-lipoxygenase protein. | 1997 | Biochem. Mol. Med. | pmid:9232199 |
| Ravasi S et al. | Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. | 2002 | Biochem. Pharmacol. | pmid:11996896 |
| Rappa G et al. | New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models. | 1999 | Biochem. Pharmacol. | pmid:10413292 |
| Agarwal R et al. | Glutathione S-transferase-dependent conjugation of leukotriene A4-methyl ester to leukotriene C4-methyl ester in mammalian skin. | 1992 | Biochem. Pharmacol. | pmid:1449522 |
| Geuenich S et al. | Induction of leukotriene production by bleomycin and asparaginase in mast cells in vitro and in patients in vivo. | 1998 | Biochem. Pharmacol. | pmid:9514079 |