LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Hypotension D007022 41 associated lipids
Gastritis D005756 27 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Osteosarcoma D012516 50 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Asthma D001249 52 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Wu L et al. Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury. 2012 J. Mol. Neurosci. pmid:22661361
Eaton A et al. Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression. 2012 J. Mol. Med. pmid:22527886
Zhou M et al. In vivo intranasal anti-CD23 treatment inhibits allergic responses in a murine model of allergic rhinitis. 2013 J. Mol. Histol. pmid:23377922
Becher UM et al. Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury. 2011 J. Mol. Cell. Cardiol. pmid:21112334
Seres I et al. The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome. 2006 J. Membr. Biol. pmid:17546512
Seno K et al. Pyrrolidine inhibitors of human cytosolic phospholipase A(2). 2000 J. Med. Chem. pmid:10737736
Mayatepek E et al. Synthesis and metabolism of leukotrienes in gamma-glutamyl transpeptidase deficiency. 2004 J. Lipid Res. pmid:14754911
Dichlberger A et al. Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells. 2014 J. Lipid Res. pmid:25114172
Sjölinder M et al. Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. 1999 J. Lipid Res. pmid:10064732
Lukic A et al. Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4. 2016 J. Lipid Res. pmid:27436590
Gibbs BF et al. Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization. 2002 J. Leukoc. Biol. pmid:12149431
Oliveira SH et al. Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. 2002 J. Leukoc. Biol. pmid:12050188
Inoue T et al. Nitric Oxide positively regulates Ag (I)-induced Ca(2+) influx and mast cell activation: role of a Nitric Oxide Synthase-independent pathway. 2009 J. Leukoc. Biol. pmid:19706839
Raible DG Erythrocytes increase leukotriene C4 release from human eosinophils: characterization and examination of possible mechanisms. 1994 J. Leukoc. Biol. pmid:8027672
Gibbs BF and Grabbe J Inhibitors of PI 3-kinase and MEK kinase differentially affect mediator secretion from immunologically activated human basophils. 1999 J. Leukoc. Biol. pmid:10380914
Blanchet MR et al. Modulation of eosinophil activation in vitro by a nicotinic receptor agonist. 2007 J. Leukoc. Biol. pmid:17289799
Hom JT et al. The amyloidogenic peptide human amylin augments the inflammatory activities of eosinophils. 1995 J. Leukoc. Biol. pmid:7595053
Malaviya R and Abraham SN Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis. 2000 J. Leukoc. Biol. pmid:10857857
Tsuruta R et al. Soluble vascular cell adhesion molecule (VCAM)-Fc fusion protein induces leukotriene C4 secretion in platelet-activating factor-stimulated eosinophils. 1999 J. Leukoc. Biol. pmid:9886248
Rossi A et al. Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}. 2005 J. Leukoc. Biol. pmid:16046553
Kobayashi H et al. Urinary trypsin inhibitor reduces the release of histamine from rat peritoneal mast cells. 1998 J. Lab. Clin. Med. pmid:9579392
Horikawa T et al. Melanocyte mitogens induce both melanocyte chemokinesis and chemotaxis. 1995 J. Invest. Dermatol. pmid:7530272
Cederholm T et al. Impaired leukotriene C4 generation in granulocytes from protein-energy malnourished chronically ill elderly. 2000 J. Intern. Med. pmid:10886494
Sichletidis L et al. Comparative efficacy of salbutamol and salmeterol in exercise-induced asthma. 1993 Mar-Apr J. Int. Med. Res. pmid:8243793
Mayatepek E et al. Acute metabolic crisis with extreme deficiency of glutathione in combination with decreased levels of leukotriene C4 in a patient with glutathione synthetase deficiency. 2004 J. Inherit. Metab. Dis. pmid:15243994
Mayatepek E et al. Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism. 2000 J. Inherit. Metab. Dis. pmid:10896305
Mayatepek E et al. LTB4 and LTC4 are absent in the cerebrospinal fluid of human immunodeficiency virus type 1-seropositive persons with toxoplasmic encephalitis: evidence for inhibition of 5-lipoxygenase by Toxoplasma gondii. 1999 J. Infect. Dis. pmid:9952384
Li GQ et al. Effects of cyclooxygenase-1 and -2 gene disruption on Helicobacter pylori-induced gastric inflammation. 2006 J. Infect. Dis. pmid:16518767
Sedgwick JB et al. Effect of isolation protocol on eosinophil function: Percoll gradients versus immunomagnetic beads. 1996 J. Immunol. Methods pmid:8914593
Laviolette M et al. Comparison of two modified techniques for purifying blood eosinophils. 1993 J. Immunol. Methods pmid:8228275
Volland H et al. Enzyme immunometric assay for leukotriene C4. 1994 J. Immunol. Methods pmid:7930643
Tsang S et al. Simplified purification of human basophils. 2000 J. Immunol. Methods pmid:10648851
Myou S et al. Activation of group IV cytosolic phospholipase A2 in human eosinophils by phosphoinositide 3-kinase through a mitogen-activated protein kinase-independent pathway. 2003 J. Immunol. pmid:14530366
Mishra NC et al. Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens. 2008 J. Immunol. pmid:18490768
Kita H et al. Eosinophil major basic protein induces degranulation and IL-8 production by human eosinophils. 1995 J. Immunol. pmid:7722326
Bandeira-Melo C et al. IL-16 promotes leukotriene C(4) and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling. 2002 J. Immunol. pmid:11971026
Zhu Y and Bertics PJ Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils. 2011 J. Immunol. pmid:21106848
Brock TG et al. Effects of granulocyte-macrophage colony-stimulating factor on eicosanoid production by mononuclear phagocytes. 1996 J. Immunol. pmid:8786314
Nunomura S et al. The FcRβ- and γ-ITAMs play crucial but distinct roles in the full activation of mast cells induced by IgEκ and Protein L. 2012 J. Immunol. pmid:22430736
Triggiani M et al. Secretory phospholipases A2 activate selective functions in human eosinophils. 2003 J. Immunol. pmid:12626587
Strait RT et al. IL-4 exacerbates anaphylaxis. 2003 J. Immunol. pmid:12646651
Kuehn HS et al. The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells. 2008 J. Immunol. pmid:19017959
Chang WC et al. All-or-none activation of CRAC channels by agonist elicits graded responses in populations of mast cells. 2007 J. Immunol. pmid:17911611
Miyamasu M et al. Chemotactic agonists induce cytokine generation in eosinophils. 1995 J. Immunol. pmid:7529800
Iikura M et al. Secretory IgA induces degranulation of IL-3-primed basophils. 1998 J. Immunol. pmid:9686618
Goulet JL et al. Genetic factors determine the contribution of leukotrienes to acute inflammatory responses. 2000 J. Immunol. pmid:10779800
Liu T et al. Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors. 2015 J. Immunol. pmid:25904552
Brock TG et al. Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils. 1999 J. Immunol. pmid:9973428
Mesquita-Santos FP et al. Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin. 2006 J. Immunol. pmid:16424158
Eglite S et al. Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils. 2000 J. Immunol. pmid:10925305